ID A0A3P8XWK5_ESOLU Unreviewed; 1373 AA. AC A0A3P8XWK5; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 02-DEC-2020, sequence version 2. DT 03-AUG-2022, entry version 15. DE SubName: Full=Transient receptor potential cation channel subfamily M member 2 {ECO:0000313|Ensembl:ENSELUP00000008843}; OS Esox lucius (Northern pike). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes; OC Esocidae; Esox. OX NCBI_TaxID=8010 {ECO:0000313|Ensembl:ENSELUP00000008843, ECO:0000313|Proteomes:UP000265140}; RN [1] {ECO:0000313|Ensembl:ENSELUP00000008843, ECO:0000313|Proteomes:UP000265140} RP NUCLEOTIDE SEQUENCE. RX PubMed=25069045; RA Rondeau E.B., Minkley D.R., Leong J.S., Messmer A.M., Jantzen J.R., RA von Schalburg K.R., Lemon C., Bird N.H., Koop B.F.; RT "The genome and linkage map of the northern pike (Esox lucius): conserved RT synteny revealed between the salmonid sister group and the Neoteleostei."; RL PLoS ONE 9:e102089-e102089(2014). RN [2] {ECO:0000313|Ensembl:ENSELUP00000008843} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2018) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family. LTrpC CC subfamily. TRPM2 sub-subfamily. {ECO:0000256|ARBA:ARBA00009501}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSELUT00000004883.2; ENSELUP00000008843.2; ENSELUG00000009466.2. DR GeneTree; ENSGT00940000156404; -. DR Proteomes; UP000265140; LG20. DR Bgee; ENSELUG00000009466; Expressed in ovary and 5 other tissues. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:InterPro. DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW. DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro. DR InterPro; IPR005821; Ion_trans_dom. DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf. DR InterPro; IPR029594; TRPM2. DR InterPro; IPR041491; TRPM_SLOG. DR PANTHER; PTHR13800:SF2; PTHR13800:SF2; 2. DR Pfam; PF00520; Ion_trans; 1. DR Pfam; PF18139; LSDAT_euk; 1. DR SUPFAM; SSF55811; SSF55811; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Calcium channel {ECO:0000256|ARBA:ARBA00022673}; KW Calcium transport {ECO:0000256|ARBA:ARBA00022568}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Ion channel {ECO:0000256|ARBA:ARBA00022673}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Reference proteome {ECO:0000313|Proteomes:UP000265140}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 772..792 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 841..860 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 866..888 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 908..928 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 995..1020 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 1046..1066 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 112..338 FT /note="LSDAT_euk" FT /evidence="ECO:0000259|Pfam:PF18139" FT DOMAIN 772..1031 FT /note="Ion_trans" FT /evidence="ECO:0000259|Pfam:PF00520" FT REGION 1165..1184 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 1169..1184 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 1373 AA; 156872 MW; 4E4CD068C2B27660 CRC64; MGESLLLEPS LAHSLAVSAA KTSKLSLCPS TQHYLASWIK DNIQKEECCF YVQGDREGVC MCGYLKIHHV DDSIKPESNQ AVTWDRHNHV RQVPTDAFGD ISFGGLGQKT GKYVRVSSDT KPEVLYQLLT EHWKLPPPNL IISVTGGAKN FYMKPQLKAQ FRRGLIKVAQ TTGAWIITGG THTGVMKHTG QAVRDYILSN NSTEGQIVTI GIATWGVIHN RKPLVHPQGR FPAYYSQDVQ TQGHMSCLDN NHSHFLLVDD GTNGRYGVEI ELRSRLERLI SQQPLGNKES GVRIPVVCVV LEGGPGTLNT IYMAMLNGTP CVVLEGSGRL ADVIAHVAGF PVAKVTLSLI HQLLKRFFCQ EYASFTELMV IEWTKKIQDM IQMSQLLTVF RISEDDHGDV DVAILQALLK ANRSSGSEGR ESWERQLELA VAWNRVDIAK SDIFTEESQW KSSDLHEAMF SALLGNKHQF VRLFLENGVC LRQFLQEDTT LCHLYTHLPT SCFFLRLLVK RIQTERTAAP LNISLRLVSD EIRHLLGSFT QPLYPLPGLA ISYLKEDVSL QSKVPLKQQF SSVPGLGPDR GGASHRDPVR DLFLWAILQN KKELAEIAWE QCLDCMSAAL AASKILKKLA EEDEEEDDEA KEMRELANYY ERHAIGVFSE CHSCDEDRAR RMLIRSSPSW GHTTCLRLAL EANDKSFIAH SGVQTLLTQI WCGELAVDNP LWRVLLCMVF FPLTYIGFLR YSDPLTRTPP GLKPLNCSMR LVSLFTSPQV KFYWNIVFYF GFLLLFSVVL MIDFQTTPSW RECLLYVWIF SLVCEEIRQL FHDPDGFPFN KKAKMYIKDM WNILDVLSIL LFIIGLVFRL TTSLFYAGKV ILCIDFIIFC LRLMAIFIVS KTLGPKIIIV KRMILDMFFF LFLLSIWVLA FGVAKQGILI NNEDRLNWIV RGAVYEPYLI IFGNMPSDID TTQFDISACT VNGTDPLKPK CPVLNEDQRP AFPEWLTIIL LCVYLLFANI LLLNLLIAIF NYTFQEVQDN TDNIWKFQRY ELIKEYYSRP ALPPPFILLS HIYIFIRRLV LRKPLQGHQT FKEELSKEEE EELLSWESFM KDNYLQSTRQ QHSQDMDQRQ ELTHPGHALR FSVQVSQSAE ALQWIMDALK SQGFNAIIDA PQLASPGKHC KDESADPKTK EVEKKSYHVN ARRLVYPGSN ITRFPVPEEK VPWEVEFSLY SPPVLNEDGQ VQSDRNPQGR TGMRGRGSLC CLGPNHILEL VLTRWRDTDG SVLEFLSVWN REESLWELPG GLVQSDEPLS DRLQSIFGQR IYNRIKQLYV LQVYEGYVDD IRNTDSAWLE TTVLNIHLDR TDHQLADINR MVRIQYSHPS YHP //