ID A0A3P8SZL5_AMPPE Unreviewed; 496 AA. AC A0A3P8SZL5; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 31-JUL-2019, entry version 6. DE SubName: Full=Lipase, hepatic a {ECO:0000313|Ensembl:ENSAPEP00000017497}; OS Amphiprion percula (Orange clownfish) (Lutjanus percula). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Pomacentridae; Amphiprion. OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000017497, ECO:0000313|Proteomes:UP000265080}; RN [1] {ECO:0000313|Ensembl:ENSAPEP00000017497, ECO:0000313|Proteomes:UP000265080} RP NUCLEOTIDE SEQUENCE. RA Lehmann R.; RT "Finding Nemo's genes: A chromosome-scale reference assembly of the RT genome of the orange clownfish Amphiprion percula."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPEP00000017497} RP IDENTIFICATION. RG Ensembl; RL Submitted (DEC-2018) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|SAAS:SAAS00553472}. CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. Lipase CC family. {ECO:0000256|RuleBase:RU004262, CC ECO:0000256|SAAS:SAAS00591292}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR Ensembl; ENSAPET00000017993; ENSAPEP00000017497; ENSAPEG00000012523. DR GeneTree; ENSGT00940000157602; -. DR Proteomes; UP000265080; Chromosome 1. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004806; F:triglyceride lipase activity; IEA:InterPro. DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro. DR GO; GO:0009725; P:response to hormone; IEA:Ensembl. DR CDD; cd00707; Pancreat_lipase_like; 1. DR Gene3D; 3.40.50.1820; -; 1. DR InterPro; IPR029058; AB_hydrolase. DR InterPro; IPR013818; Lipase/vitellogenin. DR InterPro; IPR002333; Lipase_hep. DR InterPro; IPR016272; Lipase_LIPH. DR InterPro; IPR033906; Lipase_N. DR InterPro; IPR001024; PLAT/LH2_dom. DR InterPro; IPR036392; PLAT/LH2_dom_sf. DR InterPro; IPR000734; TAG_lipase. DR PANTHER; PTHR11610; PTHR11610; 1. DR PANTHER; PTHR11610:SF2; PTHR11610:SF2; 1. DR Pfam; PF00151; Lipase; 1. DR Pfam; PF01477; PLAT; 1. DR PIRSF; PIRSF000865; Lipoprotein_lipase_LIPH; 1. DR PRINTS; PR00824; HEPLIPASE. DR PRINTS; PR00821; TAGLIPASE. DR SMART; SM00308; LH2; 1. DR SUPFAM; SSF49723; SSF49723; 1. DR SUPFAM; SSF53474; SSF53474; 1. DR PROSITE; PS50095; PLAT; 1. PE 3: Inferred from homology; KW Calcium {ECO:0000256|PIRSR:PIRSR000865-2}; KW Complete proteome {ECO:0000313|Proteomes:UP000265080}; KW Metal-binding {ECO:0000256|PIRSR:PIRSR000865-2}; KW Reference proteome {ECO:0000313|Proteomes:UP000265080}; KW Secreted {ECO:0000256|SAAS:SAAS00288740}; KW Signal {ECO:0000256|SAM:SignalP}. FT SIGNAL 1 19 {ECO:0000256|SAM:SignalP}. FT CHAIN 20 496 {ECO:0000256|SAM:SignalP}. FT /FTId=PRO_5018269106. FT DOMAIN 349 482 PLAT. {ECO:0000259|PROSITE:PS50095}. FT ACT_SITE 165 165 Nucleophile. {ECO:0000256|PIRSR: FT PIRSR000865-1}. FT ACT_SITE 191 191 Charge relay system. {ECO:0000256|PIRSR: FT PIRSR000865-1}. FT ACT_SITE 276 276 Charge relay system. {ECO:0000256|PIRSR: FT PIRSR000865-1}. FT METAL 205 205 Calcium; via carbonyl oxygen. FT {ECO:0000256|PIRSR:PIRSR000865-2}. FT METAL 210 210 Calcium. {ECO:0000256|PIRSR:PIRSR000865- FT 2}. SQ SEQUENCE 496 AA; 55770 MW; 76781F646027793C CRC64; MLGVKILCCL LLTCHLSGGK KIKGERASVA DIEQRIVLRV KEPYVSSSAF SLFLGGEDTC TLDPLQLHTL TSCGFNSSNP LIIITHGWSV DGMMESWVLR LASALKTNLV SVNVVLTDWL SLAHQHYPMA VQSTRTVGKD ISHLLQTLQE QYQYPVKKVH LIGYSLGAHI SGFAGSYLEG SEKIGRITGL DPAGPLFEGM SPTDRLSPDD AEFVDAIHTF THERMGLSVG IKQAVAHFDF YPNGGDFQPG CDLQNIYEHI TEYGLLGFEQ TVKCAHERSV HLFIDSLLNK DKQSMAYRCS DNNAFVKGVC LDCRKNRCNT LGYDIKKVRT VTSKRLYLKT RSRMPYKLYH YQFRIQFINQ VENIDPTLTV ALTGTKEESG DVVITFNEKI SGNTTFPFLI TLDKDLGDLM LVKLHWEGLA LWKNVWNRVQ TIIPWGGKET KPLLTVGRIS VKAGETQERT SFCAMTDDGQ QIEVSQDKVF VRCKEDIPKQ RRRKHN //