ID A0A3P8SRL9_AMPPE Unreviewed; 887 AA. AC A0A3P8SRL9; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 27-MAR-2024, entry version 25. DE RecName: Full=Axin-1 {ECO:0000256|ARBA:ARBA00013892}; DE AltName: Full=Axis inhibition protein 1 {ECO:0000256|ARBA:ARBA00032466}; GN Name=AXIN1 {ECO:0000313|Ensembl:ENSAPEP00000014727.1}; OS Amphiprion percula (Orange clownfish) (Lutjanus percula). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Ovalentaria; Pomacentridae; Amphiprion. OX NCBI_TaxID=161767 {ECO:0000313|Ensembl:ENSAPEP00000014727.1, ECO:0000313|Proteomes:UP000265080}; RN [1] {ECO:0000313|Ensembl:ENSAPEP00000014727.1, ECO:0000313|Proteomes:UP000265080} RP NUCLEOTIDE SEQUENCE. RA Lehmann R.; RT "Finding Nemo's genes: A chromosome-scale reference assembly of the genome RT of the orange clownfish Amphiprion percula."; RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|Ensembl:ENSAPEP00000014727.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (SEP-2023) to UniProtKB. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}. CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane CC {ECO:0000256|ARBA:ARBA00004370}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR AlphaFoldDB; A0A3P8SRL9; -. DR STRING; 161767.ENSAPEP00000014727; -. DR Ensembl; ENSAPET00000015114.1; ENSAPEP00000014727.1; ENSAPEG00000010507.1. DR GeneTree; ENSGT00940000156947; -. DR OMA; YVYTAST; -. DR Proteomes; UP000265080; Chromosome 3. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:InterPro. DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW. DR CDD; cd11582; Axin_TNKS_binding; 1. DR CDD; cd08707; RGS_Axin; 1. DR Gene3D; 1.10.196.10; -; 2. DR Gene3D; 2.40.240.130; -; 1. DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1. DR InterPro; IPR043581; Axin-like. DR InterPro; IPR014936; Axin_b-cat-bd. DR InterPro; IPR032101; Axin_TNKS-bd. DR InterPro; IPR001158; DIX. DR InterPro; IPR038207; DIX_dom_sf. DR InterPro; IPR016137; RGS. DR InterPro; IPR036305; RGS_sf. DR InterPro; IPR024066; RGS_subdom1/3. DR InterPro; IPR044926; RGS_subdomain_2. DR InterPro; IPR029071; Ubiquitin-like_domsf. DR PANTHER; PTHR46102; AXIN; 1. DR PANTHER; PTHR46102:SF3; AXIN-1; 1. DR Pfam; PF16646; AXIN1_TNKS_BD; 1. DR Pfam; PF08833; Axin_b-cat_bind; 1. DR Pfam; PF00778; DIX; 1. DR Pfam; PF00615; RGS; 1. DR PRINTS; PR01301; RGSPROTEIN. DR SMART; SM00021; DAX; 1. DR SMART; SM00315; RGS; 1. DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1. DR SUPFAM; SSF54236; Ubiquitin-like; 1. DR PROSITE; PS50841; DIX; 1. DR PROSITE; PS50132; RGS; 1. PE 4: Predicted; KW ADP-ribosylation {ECO:0000256|ARBA:ARBA00022765}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Nucleus {ECO:0000256|ARBA:ARBA00023242}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000265080}; KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}; KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687, ECO:0000256|PROSITE- KW ProRule:PRU00069}. FT DOMAIN 116..234 FT /note="RGS" FT /evidence="ECO:0000259|PROSITE:PS50132" FT DOMAIN 805..887 FT /note="DIX" FT /evidence="ECO:0000259|PROSITE:PS50841" FT REGION 12..109 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 235..265 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 278..322 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 343..373 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 523..612 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 630..771 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 418..450 FT /evidence="ECO:0000256|SAM:Coils" FT COMPBIAS 50..90 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 299..313 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 343..368 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 597..612 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 634..649 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 694..715 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 729..755 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 887 AA; 97773 MW; BE3CBEAC8964EFB1 CRC64; MSVVRELHGI GYRGGGGVVA SLSGPAHFTE DAPRPPVPGE EGSDVDPPVQ SVNIRPNTLS QTLGYPPSAL SSKMGDPSSY TPSSSSATPR RPDLDLGYEP EGSASPTPPY LKWAESLHSL LDDQEGIQLF RNFLCQEGCA DLLDFWFACS GFRKTSQEKK AKLAKAIYRK YIVDGSGIVS RQIKAATKSF IRDCVGKTHP DPAMFEQAQT EIQSMMEENT YPLFLKSDLY LEYTRTGGES PKPNPSDQSP SSGPAKPVPG YLPTLAEDEE WRCGGGGVRE VEEEKDEEEC GDTPAGRLTH SLLMQTVPQR TSASRRRQDS REYRPWREPI NPYYANMGYA RAPATSANDS EQQSMSSDAD TLSLTDSSVD GIPPYRYRKQ HRKEMHESAK ANGRVPLPHI PRTYRMPKDI HVEPERFAAE LISRLETVLR EREAQERLEE RLKRVRLEEE GDDADISMTT SMSSHSIPLP LPSSFPPLYG ARYSETTANT ATVATYGGLV AMEDSHDDDP ESILDEHVQR VMKTPGCQSP GVPNSTLGGG GRHSPPKSSR SPDGGIGPPH YPPHRGGGHS LPAAGVKGMH HHKQLYHHRG REGQEEAGSR SQANFLWNGD PANQYTGRSR NYADGAGAST LEGMGYSSKG STLSRRGCKK TSETSGKGDE SGRGLETQVP LEDLERNQKI LQWMMEGDRQ RKGSHGGSTS SSRRTGTSSE SPRPTSVERP GAVHPWVSAQ LRNNPSAGSA AIPGSSSTQV QPSHPFIQDP AMPPNPAPNP LTQLEEARRR LEEERRRNAL QQAKQRHKSG KRQVCENMTV AYYFCGEPIP YRTSVKGRVV TLGQFKELLT KKGHYRFYFK KVSDEFDCGV VFEEVRDDDA ILPIFEEKIV GKVEKVD //