ID   A0A3P8RG21_ASTCA        Unreviewed;       279 AA.
AC   A0A3P8RG21;
DT   13-FEB-2019, integrated into UniProtKB/TrEMBL.
DT   13-FEB-2019, sequence version 1.
DT   12-AUG-2020, entry version 7.
DE   RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
OS   Astatotilapia calliptera (Eastern happy) (Chromis callipterus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Haplochromini; Astatotilapia.
OX   NCBI_TaxID=8154 {ECO:0000313|Ensembl:ENSACLP00000041000};
RN   [1] {ECO:0000313|Ensembl:ENSACLP00000041000}
RP   NUCLEOTIDE SEQUENCE.
RA   Datahose.;
RL   Submitted (MAY-2018) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACLP00000041000}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (DEC-2018) to UniProtKB.
CC   -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the INSIG family.
CC       {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|RuleBase:RU241113}.
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DR   Ensembl; ENSACLT00000041964; ENSACLP00000041000; ENSACLG00000027622.
DR   GeneTree; ENSGT00580000081600; -.
DR   Proteomes; UP000265100; Chromosome 9.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR009904; INSIG-1.
DR   InterPro; IPR025929; INSIG_fam.
DR   PANTHER; PTHR15301; PTHR15301; 2.
DR   PANTHER; PTHR15301:SF11; PTHR15301:SF11; 2.
DR   Pfam; PF07281; INSIG; 1.
PE   3: Inferred from homology;
KW   Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548,
KW   ECO:0000256|RuleBase:RU241113};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113};
KW   Steroid metabolism {ECO:0000256|ARBA:ARBA00023221,
KW   ECO:0000256|RuleBase:RU241113};
KW   Sterol metabolism {ECO:0000256|ARBA:ARBA00023166};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU241113};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM        88..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        184..203
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        210..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        241..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
SQ   SEQUENCE   279 AA;  30927 MW;  F4D621C2CEA22153 CRC64;
     MNRRRGFCLE LTLKTSGDQA LKCQMPRLEE HCWSCSTSSK TETKHPSSGA NWLASRTEEM
     MSIITSVLSS AYISLQDVQT ANLIRRGVVL FTVGVFLALV LNLLQIQRNV TLFPEEVMTT
     LFSSAWWIPP CCGTGAAVIG LLYPCLDSHL GEPHKFKREW ASVMRCIAVF VGINHASVKL
     DFDNNVQLSL TLAALSLGLW WTFDRSRSGF GLGITTAFLA TVITQLLVYN GVYQYTSPDF
     LYVRSWLPCI FFSGGVTVGN IGRQLAMVKS ASLDHTVIL
//