ID A0A3P8MIK8_9INFA Unreviewed; 121 AA. AC A0A3P8MIK8; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 18-SEP-2019, entry version 6. DE RecName: Full=Nuclear export protein {ECO:0000256|HAMAP-Rule:MF_04067}; DE Short=NEP {ECO:0000256|HAMAP-Rule:MF_04067}; DE AltName: Full=Non-structural protein 2 {ECO:0000256|HAMAP-Rule:MF_04067}; DE Short=NS2 {ECO:0000256|HAMAP-Rule:MF_04067}; GN Name=NEP {ECO:0000313|EMBL:ATW74973.1}; GN Synonyms=NS {ECO:0000256|HAMAP-Rule:MF_04067, GN ECO:0000256|RuleBase:RU362104}, NS2 {ECO:0000313|EMBL:ATW74973.1}; OS Influenza A virus (A/blue-winged teal/Wyoming/AH0099021/2016(H7N9)). OC Viruses; Riboviria; Negarnaviricota; Polyploviricotina; OC Insthoviricetes; Articulavirales; Orthomyxoviridae; OC Alphainfluenzavirus. OX NCBI_TaxID=2049446 {ECO:0000313|EMBL:ATW74973.1}; RN [1] {ECO:0000313|EMBL:ATW74973.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=A/blue-winged teal/Wyoming/AH0099021/2016 RC {ECO:0000313|EMBL:ATW74973.1}; RX PubMed=28880836; RA Lee D.H., Torchetti M.K., Killian M.L., Berhane Y., Swayne D.E.; RT "Highly Pathogenic Avian Influenza A(H7N9) Virus, Tennessee, USA, RT March 2017."; RL Emerg. Infect. Dis. 23:0-0(2017). CC -!- FUNCTION: Mediates the nuclear export of encapsidated genomic RNAs CC (ribonucleoproteins, RNPs). Acts as an adapter between viral RNPs CC complexes and the nuclear export machinery of the cell. Possesses CC no intrinsic RNA-binding activity, but includes a C-terminal M1- CC binding domain. This domain is believed to allow recognition of CC RNPs bound to the protein M1. Since protein M1 is not available in CC large quantities before late stages of infection, such an indirect CC recognition mechanism probably ensures that genomic RNPs are not CC exported from the host nucleus until sufficient quantities of CC viral mRNA and progeny genomic RNA have been synthesized. CC Furthermore, the RNPs enter the host cytoplasm only when CC associated with the M1 protein that is necessary to guide them to CC the plasma membrane. May down-regulate viral RNA synthesis when CC overproduced. {ECO:0000256|HAMAP-Rule:MF_04067, CC ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967765}. CC -!- SUBUNIT: Binds M1 protein. May interact with host nucleoporin CC RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|RuleBase:RU362104}. CC -!- SUBUNIT: Interacts with protein M1. May interact with host CC nucleoporin RAB/HRB and exportin XPO1/CRM1. {ECO:0000256|HAMAP- CC Rule:MF_04067, ECO:0000256|SAAS:SAAS00967740}. CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|HAMAP- CC Rule:MF_04067, ECO:0000256|RuleBase:RU362104, CC ECO:0000256|SAAS:SAAS00967743}. Virion {ECO:0000256|HAMAP- CC Rule:MF_04067, ECO:0000256|RuleBase:RU362104}. CC -!- SIMILARITY: Belongs to the influenza viruses NEP family. CC {ECO:0000256|HAMAP-Rule:MF_04067, ECO:0000256|RuleBase:RU362104, CC ECO:0000256|SAAS:SAAS00967755}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MG266068; ATW74973.1; -; Viral_cRNA. DR SMR; A0A3P8MIK8; -. DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0039675; P:exit of virus from host cell nucleus through nuclear pore; IEA:UniProtKB-UniRule. DR GO; GO:0006405; P:RNA export from nucleus; IEA:UniProtKB-UniRule. DR HAMAP; MF_04067; INFV_NEP; 1. DR InterPro; IPR000968; Flu_NS2. DR Pfam; PF00601; Flu_NS2; 1. PE 3: Inferred from homology; KW Host nucleus {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967751}; KW Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967764}; KW Transport {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967760}; KW Virion {ECO:0000256|HAMAP-Rule:MF_04067, KW ECO:0000256|RuleBase:RU362104, ECO:0000256|SAAS:SAAS00967746}. FT MOTIF 12 21 Nuclear export signal. FT {ECO:0000256|HAMAP-Rule:MF_04067}. FT MOTIF 85 94 Nuclear export signal. FT {ECO:0000256|HAMAP-Rule:MF_04067}. SQ SEQUENCE 121 AA; 14366 MW; 607DF23FA291D2E8 CRC64; MDSNTVSSFQ DILMRMSKMQ LGSSSEDLNG MITQFESLRL YRDSLGEAVM RMGDLHSLQS RNGKWREQLS QKFEEIRWLI EEVRHRLKIT ENSFEQITFM QALQLLLEVE QEIRTFSFQL I //