ID A0A3P6HQ98_9CEST Unreviewed; 427 AA. AC A0A3P6HQ98; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 19-JAN-2022, entry version 11. DE RecName: Full=Hedgehog protein {ECO:0000256|RuleBase:RU280812}; GN ORFNames=MCOS_LOCUS3479 {ECO:0000313|EMBL:VDD77476.1}; OS Mesocestoides corti. OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda; OC Eucestoda; Cyclophyllidea; Mesocestoididae; Mesocestoides. OX NCBI_TaxID=53468 {ECO:0000313|EMBL:VDD77476.1, ECO:0000313|Proteomes:UP000267029}; RN [1] {ECO:0000313|EMBL:VDD77476.1, ECO:0000313|Proteomes:UP000267029} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RG Pathogen Informatics; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Intercellular signal essential for a variety of patterning CC events during development. {ECO:0000256|RuleBase:RU280812}. CC -!- SIMILARITY: Belongs to the hedgehog family. CC {ECO:0000256|ARBA:ARBA00010649, ECO:0000256|RuleBase:RU280812}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; UXSR01000802; VDD77476.1; -; Genomic_DNA. DR STRING; 53468.A0A3P6HQ98; -. DR Proteomes; UP000267029; Unassembled WGS sequence. DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-UniRule. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0007267; P:cell-cell signaling; IEA:InterPro. DR GO; GO:0016540; P:protein autoprocessing; IEA:InterPro. DR Gene3D; 3.30.1380.10; -; 1. DR InterPro; IPR001657; Hedgehog. DR InterPro; IPR001767; Hedgehog_Hint. DR InterPro; IPR009045; Hedgehog_sig/DD-Pept_Zn-bd_sf. DR InterPro; IPR000320; Hedgehog_signalling_dom. DR InterPro; IPR003587; Hint_dom_N. DR InterPro; IPR036844; Hint_dom_sf. DR Pfam; PF01085; HH_signal; 1. DR Pfam; PF01079; Hint; 1. DR PRINTS; PR00632; SONICHHOG. DR SMART; SM00306; HintN; 1. DR SUPFAM; SSF51294; SSF51294; 1. DR SUPFAM; SSF55166; SSF55166; 1. PE 3: Inferred from homology; KW Autocatalytic cleavage {ECO:0000256|ARBA:ARBA00022813, KW ECO:0000256|RuleBase:RU280812}; Calcium {ECO:0000256|ARBA:ARBA00022837}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, KW ECO:0000256|RuleBase:RU280812}; KW Developmental protein {ECO:0000256|RuleBase:RU280812}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU280812}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU280812}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Palmitate {ECO:0000256|ARBA:ARBA00023139}; KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU280812}; KW Reference proteome {ECO:0000313|Proteomes:UP000267029}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU280812}. FT DOMAIN 219..325 FT /note="HintN" FT /evidence="ECO:0000259|SMART:SM00306" SQ SEQUENCE 427 AA; 48243 MW; 52B906869CD16116 CRC64; MQKLVSLIHN TWPNNDVVLR ILDGWIRPPP TLLRQPKVVT KRGYTERRKQ TLQMSVPEDL VDYEPPKRFR QVTGYHSSNS LGVKVANTDS RVVMQRPRDG ANQSEATPGS SIQSPYSVYR SRYWGEELPV MGFDGYRRQQ QQLQQHPVMM EEFHYAGRAV DMILVDARSS GSSRRSSIYP GKLAQLAYYG ALFDWCYFAR QGHVHCSVKP DSIITSQWFG CFPGSAKALS TAGSPIPLSA LRVGDSIMTL DSATNTLRLT QVIAFIHRDE HQYSPWIEIV YVRAGASTTG TLRLTANHIV YRWVGEKTAV FASDVRPHDK IACDFARSDI LCQVKEVRFR NSTHADVGVY APLTLTGDMI VDGVYVSCFA HVHSEWLARL AMLPLRLKHA LFGVTSTVPQ TGVHRYADWL LQIARFLLPN QLFFSPL //