ID A0A3L6V123_APHAT Unreviewed; 456 AA. AC A0A3L6V123; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 14-DEC-2022, entry version 13. DE RecName: Full=SREBP regulating gene protein {ECO:0000256|ARBA:ARBA00023485}; GN ORFNames=DYB28_006061 {ECO:0000313|EMBL:RLO02492.1}; OS Aphanomyces astaci (Crayfish plague agent). OC Eukaryota; Sar; Stramenopiles; Oomycota; Saprolegniales; Saprolegniaceae; OC Aphanomyces. OX NCBI_TaxID=112090 {ECO:0000313|EMBL:RLO02492.1, ECO:0000313|Proteomes:UP000275652}; RN [1] {ECO:0000313|EMBL:RLO02492.1, ECO:0000313|Proteomes:UP000275652} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=KB13 {ECO:0000313|EMBL:RLO02492.1, RC ECO:0000313|Proteomes:UP000275652}; RX PubMed=29953875; DOI=10.1016/j.jip.2018.06.002; RA Minardi D., Studholme D.J., van der Giezen M., Pretto T., Oidtmann B.; RT "New genotyping method for the causative agent of crayfish plague RT (Aphanomyces astaci) based on whole genome data."; RL J. Invertebr. Pathol. 156:6-13(2018). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. CC -!- SIMILARITY: Belongs to the SPRING family. CC {ECO:0000256|ARBA:ARBA00023461}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:RLO02492.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; QUTI01033413; RLO02492.1; -; Genomic_DNA. DR AlphaFoldDB; A0A3L6V123; -. DR VEuPathDB; FungiDB:H257_06162; -. DR Proteomes; UP000275652; Unassembled WGS sequence. DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:2000640; P:positive regulation of SREBP signaling pathway; IEA:InterPro. DR InterPro; IPR045096; EDR2-like. DR InterPro; IPR009769; EDR2_C. DR InterPro; IPR019352; SPRING1. DR PANTHER; PTHR12136; ENHANCED DISEASE RESISTANCE-RELATED; 1. DR Pfam; PF07059; EDR2_C; 1. DR Pfam; PF10218; SPRING1; 1. PE 3: Inferred from homology; KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180}; KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}. FT TRANSMEM 34..58 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 268..449 FT /note="EDR2_C" FT /evidence="ECO:0000259|Pfam:PF07059" SQ SEQUENCE 456 AA; 51274 MW; FC9B6204552DF8B8 CRC64; MSSCFVAIDH HYIRCFNSQF SSTSQQQRRR ITPVLALLLL LVAATVVRFV VSIPYQYYNL HYVRPHKPTD DTIQAHILVD VAPGQKAKPP PHLRGDTFYI EPWTGQCKNT VHGLVYATDA RGITCKRSSL MPTGCCGDDV RFSCSTCDVE APHCCLAYER CVSCCMGPTN TALVHAFLAH ADPKHPVYGQ PPSDLTLFGF CTFRCRTSSA GVQHQNSYRS AKKHCYGVHR PLKELDVVNS DESALHNATT SPPRHDEYEP PMDGGQCELI WVDVFQGDRS KFFHISQRPE SVVRHFTELY PHRELFVLNI LLPGTPDVTY AQYFALRPDG VTDAFSKLWR AFMDGTDDFR NARLKLIPRV VEGPWMIRKA VGAKPFILAN ALEVQWFRGK NYLEAVVDVS SDSIAKKVTS MCRMCVASLV VDMALVVEGK SEDELPEAIL GCVRYDRLDM KFATSI //