ID A0A3G6VA23_9RHAB Unreviewed; 2066 AA. AC A0A3G6VA23; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 02-DEC-2020, entry version 9. DE RecName: Full=Large structural protein {ECO:0000256|ARBA:ARBA00020375}; DE EC=2.7.7.48 {ECO:0000256|ARBA:ARBA00012494}; DE AltName: Full=Replicase {ECO:0000256|ARBA:ARBA00017192}; DE AltName: Full=Transcriptase {ECO:0000256|ARBA:ARBA00013861}; OS Rice stripe mosaic virus. OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina; OC Monjiviricetes; Mononegavirales; Rhabdoviridae; Cytorhabdovirus; OC Rice stripe mosaic cytorhabdovirus. OX NCBI_TaxID=1931356 {ECO:0000313|EMBL:AZB50445.1}; RN [1] {ECO:0000313|EMBL:AZB50445.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=SG1 {ECO:0000313|EMBL:AZB50445.1}; RA Yang X., Zhou G.; RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=a 5'-end (5'-triphosphoguanosine)-adenosine in mRNA + S- CC adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- CC triphosphoguanosine)-adenosine in mRNA + S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:60852, Rhea:RHEA-COMP:15680, Rhea:RHEA-COMP:15682, CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:143973, CC ChEBI:CHEBI:143974; EC=2.1.1.56; CC Evidence={ECO:0000256|ARBA:ARBA00000033}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 5'-end (5'-triphosphoguanosine)-guanosine in mRNA + S- CC adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'- CC triphosphoguanosine)-guanosine in mRNA + S-adenosyl-L-homocysteine; CC Xref=Rhea:RHEA:60856, Rhea:RHEA-COMP:15681, Rhea:RHEA-COMP:15683, CC ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:143971, CC ChEBI:CHEBI:143975; EC=2.1.1.56; CC Evidence={ECO:0000256|ARBA:ARBA00000905}; CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000256|ARBA:ARBA00004328}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MH720468; AZB50445.1; -; Viral_cRNA. DR GO; GO:0019012; C:virion; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0004482; F:mRNA (guanine-N7-)-methyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-EC. DR InterPro; IPR026890; Mononeg_mRNAcap. DR InterPro; IPR014023; Mononeg_RNA_pol_cat. DR Pfam; PF14318; Mononeg_mRNAcap; 1. DR Pfam; PF00946; Mononeg_RNA_pol; 1. DR PROSITE; PS50526; RDRP_SSRNA_NEG_NONSEG; 1. PE 4: Predicted; KW mRNA capping {ECO:0000256|ARBA:ARBA00023042}; KW mRNA processing {ECO:0000256|ARBA:ARBA00022664}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}; KW Virion {ECO:0000256|ARBA:ARBA00022844}. FT DOMAIN 566..755 FT /note="RdRp catalytic" FT /evidence="ECO:0000259|PROSITE:PS50526" SQ SEQUENCE 2066 AA; 235615 MW; 4869641EE908A3DF CRC64; MDLDDGGLWR RARGLGDYHL RSALVTPSLE RFRSRKGRHR EQLCFDRMKS LGWMLRWVDQ GKLLGYLMVE ANKSLPKSIA NQELLVDTLK LEYGCLRQII MTDGDLHDQV ISYLDRKSIS THYTHGREVF QEALIVVMAL SSGREPPDHV NNLGYEMLNE ELEVPVVRTY GVIFYLFGDL IYVKYPEEEG MITLDMFRNL TDKFSERENI MIATQIGTEI LQEIYPSETV LKAVFSLWDK GLLKEGNDFY TVVKTFEAII NGMLIKNNDG TYYDPSAYLR ETVMGLPVRL RDYAQTLVSY LDSLPFNPHH LSQIGGLFRL WGHPIVDPNA GVRKVRLLGT ADKMNLTHIP TLAERKFKEI FYLSYYEKHR VYPNHNLNGE IEGSYLLSQL AQMALVNPKH ANYSLVDWDS VNTLETFPFP KSFNLSLIIA DKAVSPNREE WLELRRKGGT QMDPHIRRGP LKAMKDGVID CEKLLRKIDR NPSGLAKKHR IIGLYPKERE ENMVPRMFAL MSFDMRAFSV VSESMIADHI IPHIEGVTMT KSMLALQKEM IISTKSQASS TQSDSITFCL NIDFEKWNLN FRRWMTEGVF REMGRLFGLP EIFNRTYDIF KKSIIYLADG SFDLLLTDEL EIEPGTNPDC AYTGHVGGFE GLRQKGWTVF TAVLISSICD EMGIKTHLMG QGDNQVLMLT IYSRAARETG DLKSAPAVLE ITNTLETFKS RLVSLFANLG LPIKPLETWV SEELFAYGKT PIYRAVPLAM SLKRISRVFA FSNEDLMTLS NALGAISANA QAASMCDVHP MVSYAIAKWQ HLCCAIIFSN YHPLCGCAPH VSGEEWAIKL RLPSGKKIQE ASDGEIDERD LMKLIVTIPR SLGGYNTLTL YEMIMRGFSD PVSRDMCWLF AIASESTGKL RGYLINWIKP IVSPEVNAQH LIQDPTALNL LVPPNATSVI KRMIDKSLEA LPKRSQFAVW FSEILEISGD KEISKLAEAL TRTDSLNPRF LHDILGATLY GYCTAITSKV DKTVTLSRMA LASKDVVGAL IKGEMRLYSY FGWRTLQSRG LPLTTRCPNK WVRIIRDISW QKQIKAVSVP YPTHFLSEDI SETDRPDSWI ECYIDDAPTS DRSCMIYSTG KALPYLGSVT REKLTTRGAK AAYGTEPLVL RPINLVRTIG WFIEEDSNFA ELIKMLLGAV TDLPIEEVLY IPEMVSGSMA HRYLDMSTQH GSLWMPLYGP ATFLHMSTNT FVQYLKGTEN VTLHFQCVMG LIQYAIVNKA LGECPTKRMT RFFRSCPDCI VPIDDTLEDL PEVPSLDLIP ERTTNPYLYL KKEKIELNVR HRLAVINEIR VIARDEIEET PLLANNTLED VMSLRAAQRI FYTAKGKEAQ WDLQTADREG YLKLDFVSVI RKIIGHLFVM ESETLKAGSD YPTFQLQQRR IMRRVRQSDT SNFVHLGGFF CWQESIARIQ KLKWSVMPAT FPITAESVSL AAKMSLIGAM TSGLTPKRCD GVLAENLIPD VTRQAKNIIC LDKVFQSRCD YCYTAAMTNR WSDSINSDSI FNMRCERGHT ILSPRMLHQL RRTILPEGAL YTLAVRVVHQ SPPEASQPLQ IIPCRRERYQ ILSEADMPRQ TGYSGVYRRP TNQICMYTEV ELAKKYRLPT NSLYRILDLH DCFFSQKLMD TRGNILVVGD GYGYSSLLTK CLNPDRNVVS WTYIEPSEAL PHSLRISKPP MHYKADVQID SSPSIDRISD IHNSSYPDEF AKVVTKNGIT ALISDIETVY VSGEKSVASL INLAWNNQIQ LGALKLELMT DPLEKVVEYA HNAYQRWELF TLPGANLGGG VLYIGFYGRR EKLTGYIIPH SGVETLMDRL ATEVDEDRGR LRAEDRDRWE QLDTMESKIH LQQYHKMRLD LWFGSAYLSG YLSEDMTEFF YSVKTSYRPP AISWEKGNQA RYLYGSREEI LFMSMITVAV SSYLEDQDVL REFLSSSGWK LQWKKDKKNP RHWSPYLERS DSQLVWKKNK AMIFKLVSVL RGSKPREEYK MGKASDSIVF KYIPRKVREG EVPLCFPISK VASMSV //