ID A0A3G2PX38_9VIBR Unreviewed; 260 AA. AC A0A3G2PX38; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 08-MAY-2019, entry version 3. DE RecName: Full=Flap endonuclease Xni {ECO:0000256|HAMAP-Rule:MF_01192, ECO:0000256|SAAS:SAAS00882646}; DE Short=FEN {ECO:0000256|HAMAP-Rule:MF_01192}; DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_01192, ECO:0000256|SAAS:SAAS00563024}; GN Name=xni {ECO:0000256|HAMAP-Rule:MF_01192}; GN Synonyms=ygdG {ECO:0000256|HAMAP-Rule:MF_01192}; GN ORFNames=D0812_13935 {ECO:0000313|EMBL:AYO15440.1}; OS Vibrio owensii. OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; OC Vibrionaceae; Vibrio. OX NCBI_TaxID=696485 {ECO:0000313|EMBL:AYO15440.1, ECO:0000313|Proteomes:UP000272136}; RN [1] {ECO:0000313|EMBL:AYO15440.1, ECO:0000313|Proteomes:UP000272136} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=1700302 {ECO:0000313|EMBL:AYO15440.1, RC ECO:0000313|Proteomes:UP000272136}; RA Yan M., Wang X., Wang Y.; RT "Whole Genome of Vibrio owensii strain 170502, isolated from Acute RT Hepatopancreatic Necrosis Disease (AHPND) shrimp."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Has flap endonuclease activity. During DNA replication, CC flap endonucleases cleave the 5'-overhanging flap structure that CC is generated by displacement synthesis when DNA polymerase CC encounters the 5'-end of a downstream Okazaki fragment. CC {ECO:0000256|HAMAP-Rule:MF_01192, ECO:0000256|SAAS:SAAS00882614}. CC -!- SIMILARITY: Belongs to the Xni family. {ECO:0000256|HAMAP- CC Rule:MF_01192, ECO:0000256|SAAS:SAAS00882632}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation CC of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01192}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP033137; AYO15440.1; -; Genomic_DNA. DR RefSeq; WP_054824363.1; NZ_LKMC01000015.1. DR Proteomes; UP000272136; Chromosome 1. DR GO; GO:0017108; F:5'-flap endonuclease activity; IEA:UniProtKB-UniRule. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0030955; F:potassium ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0033567; P:DNA replication, Okazaki fragment processing; IEA:UniProtKB-UniRule. DR CDD; cd09898; H3TH_53EXO; 1. DR HAMAP; MF_01192; Xni; 1. DR InterPro; IPR020046; 5-3_exonucl_a-hlix_arch_N. DR InterPro; IPR036279; 5-3_exonuclease_C_sf. DR InterPro; IPR002421; 5-3_exonuclease_N. DR InterPro; IPR020045; DNA_polI_H3TH. DR InterPro; IPR038969; FEN_bact-like. DR InterPro; IPR008918; HhH2. DR InterPro; IPR029060; PIN-like_dom_sf. DR InterPro; IPR022895; Xni. DR PANTHER; PTHR42646; PTHR42646; 1. DR Pfam; PF01367; 5_3_exonuc; 1. DR Pfam; PF02739; 5_3_exonuc_N; 1. DR SMART; SM00475; 53EXOc; 1. DR SMART; SM00279; HhH2; 1. DR SUPFAM; SSF47807; SSF47807; 1. DR SUPFAM; SSF88723; SSF88723; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000272136}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_01192, KW ECO:0000256|SAAS:SAAS00882656}; KW Endonuclease {ECO:0000256|HAMAP-Rule:MF_01192, KW ECO:0000256|SAAS:SAAS00882791, ECO:0000313|EMBL:AYO15440.1}; KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01192, KW ECO:0000256|SAAS:SAAS00427537}; KW Magnesium {ECO:0000256|HAMAP-Rule:MF_01192, KW ECO:0000256|SAAS:SAAS00882663}; KW Metal-binding {ECO:0000256|HAMAP-Rule:MF_01192, KW ECO:0000256|SAAS:SAAS00882727}; KW Nuclease {ECO:0000256|HAMAP-Rule:MF_01192, KW ECO:0000256|SAAS:SAAS00427491}; KW Potassium {ECO:0000256|HAMAP-Rule:MF_01192, KW ECO:0000256|SAAS:SAAS00882729}. FT DOMAIN 3 254 53EXOc. {ECO:0000259|SMART:SM00475}. FT REGION 189 194 Interaction with DNA. {ECO:0000256|HAMAP- FT Rule:MF_01192}. FT METAL 109 109 Magnesium. {ECO:0000256|HAMAP-Rule: FT MF_01192}. FT METAL 176 176 Potassium; via carbonyl oxygen. FT {ECO:0000256|HAMAP-Rule:MF_01192}. FT METAL 185 185 Potassium; via carbonyl oxygen. FT {ECO:0000256|HAMAP-Rule:MF_01192}. FT METAL 187 187 Potassium; via carbonyl oxygen. FT {ECO:0000256|HAMAP-Rule:MF_01192}. FT METAL 190 190 Potassium; via carbonyl oxygen. FT {ECO:0000256|HAMAP-Rule:MF_01192}. SQ SEQUENCE 260 AA; 29317 MW; 732C39EAE95ACCAE CRC64; MSIHLVIIDA LNLIRRVHSA QPDPTDIART ITTTCRTLTR ILSEAQPTHI IAVFDHHEQD RGWRAEILPD YKQNRKPMPE PLMQGLDAIQ QAWWEQGIDS LLSEGDEADD LVATLATKVA SHGEKVTIVS TDKGYCQLLS PTLQIRDYFQ HRWLDEPFIE KEFGVKPSQL ADYWGLTGIS SSQVPGIPGV GPKAAKEILT QFEDIEAAYA SEELVPKYRK KFDEHIESAR LCKKVAALKC DIELGFNLQD IRFTGPNKTQ //