ID A0A3G2FGC8_9GAMM Unreviewed; 524 AA. AC A0A3G2FGC8; DT 13-FEB-2019, integrated into UniProtKB/TrEMBL. DT 13-FEB-2019, sequence version 1. DT 27-MAR-2024, entry version 22. DE RecName: Full=Na(+)/H(+) antiporter NhaB {ECO:0000256|HAMAP-Rule:MF_01599}; DE AltName: Full=Sodium/proton antiporter NhaB {ECO:0000256|HAMAP-Rule:MF_01599}; GN Name=nhaB {ECO:0000256|HAMAP-Rule:MF_01599, GN ECO:0000313|EMBL:AYM90619.1}; GN ORFNames=D9980_08485 {ECO:0000313|EMBL:AYM90619.1}; OS Serratia sp. 3ACOL1. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Yersiniaceae; Serratia. OX NCBI_TaxID=2448483 {ECO:0000313|EMBL:AYM90619.1, ECO:0000313|Proteomes:UP000281837}; RN [1] {ECO:0000313|Proteomes:UP000281837} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Bekkelund A.K., Markussen T., Sorum H.; RT "Characterization of cellulolytic bacteria isolated from the larvae of RT long-horned wood boring beetles inhabiting Norwegian Boreal forests."; RL Submitted (OCT-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Na(+)/H(+) antiporter that extrudes sodium in exchange for CC external protons. {ECO:0000256|HAMAP-Rule:MF_01599}. CC -!- CATALYTIC ACTIVITY: CC Reaction=3 H(+)(out) + 2 Na(+)(in) = 3 H(+)(in) + 2 Na(+)(out); CC Xref=Rhea:RHEA:29247, ChEBI:CHEBI:15378, ChEBI:CHEBI:29101; CC Evidence={ECO:0000256|HAMAP-Rule:MF_01599}; CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01599}; CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01599}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the NhaB Na(+)/H(+) (TC 2.A.34) antiporter CC family. {ECO:0000256|ARBA:ARBA00006036, ECO:0000256|HAMAP- CC Rule:MF_01599}. CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_01599}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP033055; AYM90619.1; -; Genomic_DNA. DR AlphaFoldDB; A0A3G2FGC8; -. DR Proteomes; UP000281837; Chromosome. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro. DR HAMAP; MF_01599; NhaB; 1. DR InterPro; IPR004671; Na+/H+_antiporter_NhaB. DR NCBIfam; TIGR00774; NhaB; 1. DR PANTHER; PTHR43302:SF1; NA(+)_H(+) ANTIPORTER NHAB; 1. DR PANTHER; PTHR43302; TRANSPORTER ARSB-RELATED; 1. DR Pfam; PF06450; NhaB; 1. PE 3: Inferred from homology; KW Antiport {ECO:0000256|ARBA:ARBA00022449, ECO:0000256|HAMAP-Rule:MF_01599}; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP- KW Rule:MF_01599}; Ion transport {ECO:0000256|HAMAP-Rule:MF_01599}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01599}; KW Sodium {ECO:0000256|HAMAP-Rule:MF_01599}; KW Sodium transport {ECO:0000256|ARBA:ARBA00023201, ECO:0000256|HAMAP- KW Rule:MF_01599}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP- KW Rule:MF_01599}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP- KW Rule:MF_01599}; Transport {ECO:0000256|HAMAP-Rule:MF_01599}. FT TRANSMEM 20..39 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" FT TRANSMEM 70..90 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" FT TRANSMEM 96..118 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" FT TRANSMEM 130..156 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" FT TRANSMEM 245..268 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" FT TRANSMEM 299..315 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" FT TRANSMEM 350..368 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" FT TRANSMEM 478..497 FT /note="Helical" FT /evidence="ECO:0000256|HAMAP-Rule:MF_01599" SQ SEQUENCE 524 AA; 56989 MW; 01AF74E92CC79144 CRC64; MDMTIRSALV KNFLGASPDW YKLAIISFLV INPLVFFLVS PFVAGWLLVI EFIFTLAMAL KCYPLQPGGL LAIEAVLIGM TSPAHVSAEI ASNLEVLLLL VFMVAGIYFM KQLLLFVFTK LLLNIRSKML LSLSFCVAAA LLSAFLDALT VVAVVISVGT GFYSIYHNVA SNQKIDISDD SHLEDADHKQ TLEQFRGFLR SLLMHAGVGT ALGGVMTMVG EPQNLIIAKS AGWGFGEFFL RMTPVTLPVF VCGLLVCLLV ERFAVFGYGT KLPDQVRSVL KEFDRQATAK RSRQEKMKLV VQALIGLWLV IALAFHLAEV GLIGLSVIIL ATSLCGVTDE HAIGKAFQEA LPFTALLTVF FTVVAVIIEQ QLFTPVIHYV LQAPPSSQLS LFYLFNGLLS SVSDNVFVGT VYINEARAAL ADGAISLQQF ELLAVAINTG TNLPSVATPN GQAAFLFLLT SALAPLVRLS YGRMVWMALP YTVVLTLVGL LCVQHTLAPV TDLFTQWQWL MPLPLDATAP IAAH //