ID   A0A3B8WBH7_MARNT        Unreviewed;       504 AA.
AC   A0A3B8WBH7;
DT   16-JAN-2019, integrated into UniProtKB/TrEMBL.
DT   16-JAN-2019, sequence version 1.
DT   14-DEC-2022, entry version 12.
DE   RecName: Full=Putative thymidine phosphorylase {ECO:0000256|HAMAP-Rule:MF_00703};
DE            EC=2.4.2.4 {ECO:0000256|HAMAP-Rule:MF_00703};
DE   AltName: Full=TdRPase {ECO:0000256|HAMAP-Rule:MF_00703};
GN   ORFNames=DCF82_05310 {ECO:0000313|EMBL:HAC27217.1};
OS   Marinobacter nauticus (Marinobacter hydrocarbonoclasticus) (Marinobacter
OS   aquaeolei).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Marinobacteraceae; Marinobacter.
OX   NCBI_TaxID=2743 {ECO:0000313|EMBL:HAC27217.1, ECO:0000313|Proteomes:UP000261325};
RN   [1] {ECO:0000313|EMBL:HAC27217.1, ECO:0000313|Proteomes:UP000261325}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UBA9049 {ECO:0000313|EMBL:HAC27217.1};
RX   PubMed=30148503; DOI=.1038/nbt.4229;
RA   Parks D.H., Chuvochina M., Waite D.W., Rinke C., Skarshewski A.,
RA   Chaumeil P.A., Hugenholtz P.;
RT   "A standardized bacterial taxonomy based on genome phylogeny substantially
RT   revises the tree of life.";
RL   Nat. Biotechnol. 36:996-1004(2018).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate +
CC         thymine; Xref=Rhea:RHEA:16037, ChEBI:CHEBI:17748, ChEBI:CHEBI:17821,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57259; EC=2.4.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00000749, ECO:0000256|HAMAP-
CC         Rule:MF_00703};
CC   -!- SIMILARITY: Belongs to the thymidine/pyrimidine-nucleoside
CC       phosphorylase family. Type 2 subfamily. {ECO:0000256|HAMAP-
CC       Rule:MF_00703}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:HAC27217.1}.
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DR   EMBL; DLYI01000063; HAC27217.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A3B8WBH7; -.
DR   Proteomes; UP000261325; Unassembled WGS sequence.
DR   GO; GO:0004645; F:1,4-alpha-oligoglucan phosphorylase activity; IEA:InterPro.
DR   GO; GO:0009032; F:thymidine phosphorylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006206; P:pyrimidine nucleobase metabolic process; IEA:InterPro.
DR   GO; GO:0006213; P:pyrimidine nucleoside metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.1030.10; -; 1.
DR   Gene3D; 3.90.1170.30; -; 1.
DR   HAMAP; MF_00703; Thymid_phosp_2; 1.
DR   InterPro; IPR000312; Glycosyl_Trfase_fam3.
DR   InterPro; IPR017459; Glycosyl_Trfase_fam3_N_dom.
DR   InterPro; IPR036320; Glycosyl_Trfase_fam3_N_dom_sf.
DR   InterPro; IPR035902; Nuc_phospho_transferase.
DR   InterPro; IPR036566; PYNP-like_C_sf.
DR   InterPro; IPR013102; PYNP_C.
DR   InterPro; IPR017872; Pyrmidine_PPase_CS.
DR   InterPro; IPR028579; Thym_Pase_Put.
DR   InterPro; IPR013466; Thymidine/AMP_Pase.
DR   InterPro; IPR000053; Thymidine/pyrmidine_PPase.
DR   PANTHER; PTHR10515; THYMIDINE PHOSPHORYLASE; 1.
DR   Pfam; PF02885; Glycos_trans_3N; 1.
DR   Pfam; PF00591; Glycos_transf_3; 1.
DR   Pfam; PF07831; PYNP_C; 1.
DR   SMART; SM00941; PYNP_C; 1.
DR   SUPFAM; SSF52418; Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain; 1.
DR   SUPFAM; SSF47648; Nucleoside phosphorylase/phosphoribosyltransferase N-terminal domain; 1.
DR   SUPFAM; SSF54680; Pyrimidine nucleoside phosphorylase C-terminal domain; 1.
DR   TIGRFAMs; TIGR02645; ARCH_P_rylase; 1.
DR   PROSITE; PS00647; THYMID_PHOSPHORYLASE; 1.
PE   3: Inferred from homology;
KW   Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676, ECO:0000256|HAMAP-
KW   Rule:MF_00703};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW   Rule:MF_00703}.
FT   DOMAIN          431..498
FT                   /note="PYNP_C"
FT                   /evidence="ECO:0000259|SMART:SM00941"
SQ   SEQUENCE   504 AA;  53104 MW;  EC7FBA258E000684 CRC64;
     MVASSSQLRV FKMGINTHQE PVVYMRDDCD VCLSEGFAAS SRVGISSQGR SIIATLNISS
     DETVPKGYAG LSDIAIERLG VAQSDLVSVH HAPYIESLSL VRRKVFGHSL LPAEMARIVS
     DISAHKYSDV EIACFLSACA GGRLGFDEIV ALTQAMVNCG QQLDWPGVDR VFDKHCVGGL
     PGNRTTPLVV SIVSAAGLVM PKTSSRAITS PAGTADTMEA LTNVRLGLNE IRRVVRETGA
     CLAWGGAMNL SPADDLLIRI ERALDLDGEG QLVASVLSKK IAAGSTHAVI DIPVGETAKV
     RTPGDADRLA SLFTSVGAAC GLKVRCIATD GSKPVGAGIG PTEEARDVLA VLQGKQGAPR
     DLRGRAILLA GHLFDLADGL GVKEGMIKAE RLLQNGSAWE QFKRITKAQG GLKSLGEARF
     RRPVLSSESG TIVSIDNRRL ARVAKLAGAP ASSTAGLRLL VNVGDIVIKG EPLYELLSDS
     PGQQDYALAF NDMGPAIFTV SQEE
//