ID A0A3B8L0Z4_9BACT Unreviewed; 840 AA. AC A0A3B8L0Z4; DT 16-JAN-2019, integrated into UniProtKB/TrEMBL. DT 16-JAN-2019, sequence version 1. DT 31-JUL-2019, entry version 6. DE RecName: Full=Endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122}; DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122}; DE Flags: Fragment; GN ORFNames=DCE03_05900 {ECO:0000313|EMBL:HAA48000.1}; OS Synergistaceae bacterium. OC Bacteria; Synergistetes; Synergistia; Synergistales; Synergistaceae; OC unclassified Synergistaceae. OX NCBI_TaxID=2053624 {ECO:0000313|EMBL:HAA48000.1}; RN [1] {ECO:0000313|EMBL:HAA48000.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=UBA9913 {ECO:0000313|EMBL:HAA48000.1}; RX PubMed=30148503; DOI=.1038/nbt.4229; RA Parks D.H., Chuvochina M., Waite D.W., Rinke C., Skarshewski A., RA Chaumeil P.A., Hugenholtz P.; RT "A standardized bacterial taxonomy based on genome phylogeny RT substantially revises the tree of life."; RL Nat. Biotechnol. 36:996-1004(2018). CC -!- CATALYTIC ACTIVITY: CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53; CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122}; CC -!- SIMILARITY: Belongs to the peptidase S16 family. CC {ECO:0000256|PROSITE-ProRule:PRU01122}. CC -!- CAUTION: The sequence shown here is derived from an CC EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is CC preliminary data. {ECO:0000313|EMBL:HAA48000.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DLVO01000135; HAA48000.1; -; Genomic_DNA. DR GO; GO:0005524; F:ATP binding; IEA:InterPro. DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule. DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro. DR Gene3D; 3.30.230.10; -; 1. DR InterPro; IPR041699; AAA_32. DR InterPro; IPR008269; Lon_proteolytic. DR InterPro; IPR027065; Lon_Prtase. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold. DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr. DR PANTHER; PTHR10046; PTHR10046; 2. DR Pfam; PF13654; AAA_32; 1. DR Pfam; PF05362; Lon_C; 1. DR SUPFAM; SSF52540; SSF52540; 1. DR SUPFAM; SSF54211; SSF54211; 1. DR PROSITE; PS51786; LON_PROTEOLYTIC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122}; KW Protease {ECO:0000256|PROSITE-ProRule:PRU01122, KW ECO:0000313|EMBL:HAA48000.1}; KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}. FT DOMAIN 588 783 Lon proteolytic. {ECO:0000259|PROSITE: FT PS51786}. FT REGION 186 226 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT REGION 820 840 Disordered. {ECO:0000256|SAM:MobiDB- FT lite}. FT COILED 147 167 {ECO:0000256|SAM:Coils}. FT COILED 251 271 {ECO:0000256|SAM:Coils}. FT COMPBIAS 186 203 Polyampholyte. {ECO:0000256|SAM:MobiDB- FT lite}. FT ACT_SITE 678 678 {ECO:0000256|PROSITE-ProRule:PRU01122}. FT ACT_SITE 721 721 {ECO:0000256|PROSITE-ProRule:PRU01122}. FT NON_TER 840 840 {ECO:0000313|EMBL:HAA48000.1}. SQ SEQUENCE 840 AA; 94044 MW; 4D2DE1C63381BFF4 CRC64; MKKASLPLKI EDLRKRTNPD SLGLETTRDV ECLDALIGQE RAVKSISFGL EVQNKGYNIF VVGDHGSGRT TYSLERIRDR ARSEKTPDDV IYVYNFKNPD EPLAINIPAG QGEKLASHLD DLVEELKSAL SKAFENSQYE DAKAQLVKEF QEQVNTLMEE LRTWAAEKGF AIKRTPQGFV NIPLVEEEKS EADQQKNGID SDEKDAGNSG NGPGKKLKEM QQEDFEALSE EEKKALQEAS EEVSQKTLEV LRKIRDKEKT LKEKIRDLEA EICRSAIRPY LQETKERFQA EGKLGEWIDA LTEDIIENFN IFVAAARDDS GPEVDFSRYS VNVFVSNDPE AGAPVIWETN PTYYNLCGKI EYESRQGVLT TDFRKVVAGA IQRANGGYLV LHAEEVLRNF MSWDALKRAL RTQELAVENL GEQLGMIPVS SLRPQPVQLR TKVVLIGTPW LYYLLNIYDP EVQKLFKIKA DFDVDMPRTA ETQKQMACFV SGYVTKEGHR HFSAEGIAEL IEWSSRLAGH SERMSTQFNK ITEVIVEASA WAGTEGEVTV GSRHVRKALK EKAFRVNLVE ERLHRAFSEK TIRIQTHGER IGQINGLTVV DMRDHVFGHP VRITANVYMG SEGIVNIERE VKMTGPIHNK GLLILGSYLG KKYAQDMPLS LTARITFEQT YSGVEGDSAS STELYCLLSA LSDVPLRQGI AVTGSVDQHG NIQPIGGVNE KIEGFFEYCK TSGLTGNQGV IIPKQNVKNL MLDHELITAV EEGKFNIWPV ETIEEGIEIL TGIPAGEPDE KGGYPEGTIH GKAMKKLRGW VKKAARLKKE VETMEESAVR PDEDPDEGDS //