ID   A0A3A5LQN3_STAAU        Unreviewed;       354 AA.
AC   A0A3A5LQN3; A0A4V1C9J9;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   29-SEP-2021, entry version 21.
DE   RecName: Full=3-dehydroquinate synthase {ECO:0000256|HAMAP-Rule:MF_00110};
DE            Short=DHQS {ECO:0000256|HAMAP-Rule:MF_00110};
DE            EC=4.2.3.4 {ECO:0000256|HAMAP-Rule:MF_00110};
GN   Name=aroB {ECO:0000256|HAMAP-Rule:MF_00110,
GN   ECO:0000313|EMBL:CAC6438418.1};
GN   ORFNames=BSG37_07765 {ECO:0000313|EMBL:APZ40288.1}, E5491_07685
GN   {ECO:0000313|EMBL:QBZ85664.1}, FAF32_010635
GN   {ECO:0000313|EMBL:TXD26079.1}, G6X35_10705
GN   {ECO:0000313|EMBL:NGV91864.1}, G6X37_05040
GN   {ECO:0000313|EMBL:NGS81730.1}, G6Y24_13150
GN   {ECO:0000313|EMBL:NGW68405.1}, GO810_08255
GN   {ECO:0000313|EMBL:MVK38039.1}, SAMEA103891454_01922
GN   {ECO:0000313|EMBL:CAC6438418.1};
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:QBZ85664.1, ECO:0000313|Proteomes:UP000296718};
RN   [1] {ECO:0000313|EMBL:APZ40288.1, ECO:0000313|Proteomes:UP000187007}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCI 28 {ECO:0000313|EMBL:APZ40288.1,
RC   ECO:0000313|Proteomes:UP000187007};
RA   Nicholson T.L., Bayles D.O., Hau S.J.;
RT   "Staphylococcus aureus UCI 28 MRSA ST5.";
RL   Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:QBZ85664.1, ECO:0000313|Proteomes:UP000296718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCUH29 {ECO:0000313|EMBL:QBZ85664.1,
RC   ECO:0000313|Proteomes:UP000296718};
RA   Silverstein K., Yang J.;
RT   "Complete Genome Sequence of the Hospital-Acquired Methicillin-Resistant
RT   Staphylococcus aureus Strain WCUH29.";
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:QBZ85664.1, ECO:0000313|Proteomes:UP000296718}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WCUH29 {ECO:0000313|EMBL:QBZ85664.1,
RC   ECO:0000313|Proteomes:UP000296718};
RA   Ji Y., Lei T., Zhang Y.;
RL   Submitted (APR-2019) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:TXD26079.1, ECO:0000313|Proteomes:UP000307619}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=14 {ECO:0000313|EMBL:TXD26079.1,
RC   ECO:0000313|Proteomes:UP000307619};
RA   Fouts D., Sutton G., Singh I., Kevin A.;
RT   "WGS of SAMN11458148.";
RL   Submitted (AUG-2019) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:MVK38039.1, ECO:0000313|Proteomes:UP000432480}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=S_3030.LEPB.AN {ECO:0000313|EMBL:MVK38039.1,
RC   ECO:0000313|Proteomes:UP000432480};
RA   Stine O.C.;
RT   "Implementation of targeted gown and glove precautions to prevent
RT   Staphylococcus aureus acquisition in community-based nursing homes.";
RL   Submitted (NOV-2019) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|Proteomes:UP000473113, ECO:0000313|Proteomes:UP000474795}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UB561 {ECO:0000313|EMBL:NGV91864.1,
RC   ECO:0000313|Proteomes:UP000474795}, UB564
RC   {ECO:0000313|EMBL:NGS81730.1, ECO:0000313|Proteomes:UP000480948}, and
RC   UG255 {ECO:0000313|EMBL:NGW68405.1,
RC   ECO:0000313|Proteomes:UP000473113};
RA   Castro-Cardozo B., Berrio M., Vargas M.L., Carvajal L.P., Millan L.V.,
RA   Rios R., Hernandez A., Rincon S.L., Cubides P., Forero E., Dinh A.,
RA   Seas C., Munita J.M., Arias C.A., Reyes J., Diaz L.;
RT   "Detection of Heterogeneous Vancomycin Intermediate Resistance in
RT   Methicillin Resistant Staphylococcus aureus Isolates from Latin-America.";
RL   Submitted (FEB-2020) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|EMBL:CAC6438418.1, ECO:0000313|Proteomes:UP000504931}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRS749 {ECO:0000313|EMBL:CAC6438418.1,
RC   ECO:0000313|Proteomes:UP000504931};
RG   Pathogen Informatics;
RL   Submitted (JUN-2020) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate
CC       7-phosphate (DAHP) to dehydroquinate (DHQ). {ECO:0000256|HAMAP-
CC       Rule:MF_00110}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-
CC         dehydroquinate + phosphate; Xref=Rhea:RHEA:21968, ChEBI:CHEBI:32364,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394; EC=4.2.3.4;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00110};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00110};
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|HAMAP-Rule:MF_00110};
CC       Note=Binds 1 divalent metal cation per subunit. Can use either Co(2+)
CC       or Zn(2+). {ECO:0000256|HAMAP-Rule:MF_00110};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911,
CC         ECO:0000256|HAMAP-Rule:MF_00110};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       2/7. {ECO:0000256|HAMAP-Rule:MF_00110}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00110}.
CC   -!- SIMILARITY: Belongs to the sugar phosphate cyclases superfamily.
CC       Dehydroquinate synthase family. {ECO:0000256|HAMAP-Rule:MF_00110}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|HAMAP-Rule:MF_00110}.
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DR   EMBL; CP018768; APZ40288.1; -; Genomic_DNA.
DR   EMBL; CAIHGC010000006; CAC6438418.1; -; Genomic_DNA.
DR   EMBL; WPTJ01000097; MVK38039.1; -; Genomic_DNA.
DR   EMBL; JAALQG010000152; NGS81730.1; -; Genomic_DNA.
DR   EMBL; JAALTV010000370; NGV91864.1; -; Genomic_DNA.
DR   EMBL; JAALTR010000315; NGW68405.1; -; Genomic_DNA.
DR   EMBL; CP039156; QBZ85664.1; -; Genomic_DNA.
DR   EMBL; SULB02000042; TXD26079.1; -; Genomic_DNA.
DR   RefSeq; WP_000776312.1; NZ_WYDB01000002.1.
DR   EnsemblBacteria; GBV19341; GBV19341; M1K003_0309.
DR   EnsemblBacteria; QBZ85664; QBZ85664; E5491_07685.
DR   KEGG; saud:CH52_11745; -.
DR   UniPathway; UPA00053; UER00085.
DR   Proteomes; UP000187007; Chromosome.
DR   Proteomes; UP000296718; Chromosome.
DR   Proteomes; UP000307619; Unassembled WGS sequence.
DR   Proteomes; UP000432480; Unassembled WGS sequence.
DR   Proteomes; UP000473113; Unassembled WGS sequence.
DR   Proteomes; UP000474795; Unassembled WGS sequence.
DR   Proteomes; UP000480948; Unassembled WGS sequence.
DR   Proteomes; UP000504931; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003856; F:3-dehydroquinate synthase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   HAMAP; MF_00110; DHQ_synthase; 1.
DR   InterPro; IPR016037; DHQ_synth_AroB.
DR   InterPro; IPR030963; DHQ_synth_fam.
DR   InterPro; IPR030960; DHQS/DOIS.
DR   Pfam; PF01761; DHQ_synthase; 1.
DR   PIRSF; PIRSF001455; DHQ_synth; 1.
DR   TIGRFAMs; TIGR01357; aroB; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00110};
KW   Aromatic amino acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00110};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285, ECO:0000256|HAMAP-Rule:MF_00110};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00110};
KW   Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000256|HAMAP-Rule:MF_00110};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW   Rule:MF_00110};
KW   NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|HAMAP-Rule:MF_00110};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW   Rule:MF_00110};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00110}.
FT   DOMAIN          62..316
FT                   /note="DHQ_synthase"
FT                   /evidence="ECO:0000259|Pfam:PF01761"
FT   NP_BIND         100..104
FT                   /note="NAD"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
FT   NP_BIND         124..125
FT                   /note="NAD"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
FT   NP_BIND         163..166
FT                   /note="NAD"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
FT   METAL           178
FT                   /note="Cobalt or zinc"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
FT   METAL           242
FT                   /note="Cobalt or zinc; via tele nitrogen"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
FT   METAL           256
FT                   /note="Cobalt or zinc; via tele nitrogen"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
FT   BINDING         136
FT                   /note="NAD; via carbonyl oxygen"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
FT   BINDING         145
FT                   /note="NAD"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_00110"
SQ   SEQUENCE   354 AA;  40237 MW;  59AB2D0C089B872D CRC64;
     MKLQTTYPSN NYPIFVEHGA IDHISTYIDQ FDQSFILIDE HVNQYFADKF DDILSYENVH
     KVIIPAGEKT KTFEQYQETL EYILSHHVTR NTAIIAVGGG ATGDFAGFVA ATLLRGVHFI
     QVPTTILAHD SSVGGKVGIN SKQGKNLIGA FYRPTAVIYD LDFLKTLPFE QILSGYAEVY
     KHALLNGEST TQEIEQHFKD REILQSLNGM DKYIAKGIET KLDIVVADEK EQGVRKFLNL
     GHTFGHAVEY NHKIAHGHAV MIGIIYQFIV ANILFNSNHD IQHYINYLTK LGYPLETITD
     IDFETIYQYM LSDKKNDKQG VQMVLIKHFG DIVVQHIDQT TLQHACEQLK TYFK
//