ID   A0A3A5LQN3_STAAU        Unreviewed;       354 AA.
AC   A0A3A5LQN3;
DT   05-DEC-2018, integrated into UniProtKB/TrEMBL.
DT   05-DEC-2018, sequence version 1.
DT   16-JAN-2019, entry version 2.
DE   RecName: Full=3-dehydroquinate synthase {ECO:0000256|HAMAP-Rule:MF_00110, ECO:0000256|SAAS:SAAS00210916};
DE            Short=DHQS {ECO:0000256|HAMAP-Rule:MF_00110};
DE            EC=4.2.3.4 {ECO:0000256|HAMAP-Rule:MF_00110, ECO:0000256|SAAS:SAAS00210941};
GN   Name=aroB {ECO:0000256|HAMAP-Rule:MF_00110,
GN   ECO:0000313|EMBL:GBU55489.1};
GN   ORFNames=D5R87_08095 {ECO:0000313|EMBL:RJT61195.1}, D5R88_13345
GN   {ECO:0000313|EMBL:RJT70085.1}, M1C031_0584
GN   {ECO:0000313|EMBL:GBU55489.1}, M1C066_0379
GN   {ECO:0000313|EMBL:GBV06616.1}, M1K003_0309
GN   {ECO:0000313|EMBL:GBV19341.1}, M1K028_1321
GN   {ECO:0000313|EMBL:GBV51239.1}, M1K094_1249
GN   {ECO:0000313|EMBL:GBV91852.1}, M6C066_0602
GN   {ECO:0000313|EMBL:GBX72202.1}, M6K030_1047
GN   {ECO:0000313|EMBL:GBY08447.1}, M6K049_0498
GN   {ECO:0000313|EMBL:GBY33483.1}, M6K089_0349
GN   {ECO:0000313|EMBL:GBY79533.1}, M6K094_0693
GN   {ECO:0000313|EMBL:GBY82276.1}, M6K136_0941
GN   {ECO:0000313|EMBL:GBZ28725.1}, M6K137_1504
GN   {ECO:0000313|EMBL:GBZ31715.1}, M6K146_1189
GN   {ECO:0000313|EMBL:GBZ44258.1}, M6K224_0646
GN   {ECO:0000313|EMBL:GCA30268.1}, MA46_11360
GN   {ECO:0000313|EMBL:RIZ62469.1};
OS   Staphylococcus aureus.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280 {ECO:0000313|EMBL:RJT61195.1};
RN   [1] {ECO:0000313|EMBL:RIZ62469.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SA33 {ECO:0000313|EMBL:RIZ62469.1};
RA   Van Tyne D., Dabul N., Camargo I., Gilmore M.S.;
RT   "Comparative genomics of S. aureus and E. faecalis strains from
RT   Brazil.";
RL   Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:GBU55489.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=M1C031 {ECO:0000313|EMBL:GBU55489.1}, M1C066
RC   {ECO:0000313|EMBL:GBV06616.1}, M1K003 {ECO:0000313|EMBL:GBV19341.1},
RC   M1K028 {ECO:0000313|EMBL:GBV51239.1}, M1K094
RC   {ECO:0000313|EMBL:GBV91852.1}, M6C066 {ECO:0000313|EMBL:GBX72202.1},
RC   M6K030 {ECO:0000313|EMBL:GBY08447.1}, M6K049
RC   {ECO:0000313|EMBL:GBY33483.1}, M6K089 {ECO:0000313|EMBL:GBY79533.1},
RC   M6K094 {ECO:0000313|EMBL:GBY82276.1}, M6K136
RC   {ECO:0000313|EMBL:GBZ28725.1}, M6K137 {ECO:0000313|EMBL:GBZ31715.1},
RC   M6K146 {ECO:0000313|EMBL:GBZ44258.1}, and M6K224
RC   {ECO:0000313|EMBL:GCA30268.1};
RA   Nakamura Y., Takahashi H., Takaya A., Inoue Y., Katayama Y.,
RA   Kusuya Y., Shoji T., Takada S., Nakagawa S., Oguma R., Ozawa N.,
RA   Yamaide F., Suzuki S., Villaruz A., Otto M., Matsue H., Nunez G.,
RA   Shimojo N.;
RT   "Protection against atopic dermatitis through acquisition of
RT   Staphylococcus quorum-sensing agr mutations in the skin.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:RJT61195.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SABHZ053 {ECO:0000313|EMBL:RJT61195.1};
RA   Tang B., Zhang L., Chang J., Luo Y.;
RT   "Genome sequencing of Staphylococcus aureus strain SABHZ053.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:RJT70085.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SABHZ079 {ECO:0000313|EMBL:RJT70085.1};
RA   Tang B., Zhang L., Chang J., Luo Y.;
RT   "Genome sequencing of Staphylococcus aureus strain SABHZ079.";
RL   Submitted (SEP-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the conversion of 3-deoxy-D-arabino-
CC       heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).
CC       {ECO:0000256|HAMAP-Rule:MF_00110, ECO:0000256|SAAS:SAAS00858858}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-
CC         dehydroquinate + phosphate; Xref=Rhea:RHEA:21968,
CC         ChEBI:CHEBI:32364, ChEBI:CHEBI:43474, ChEBI:CHEBI:58394;
CC         EC=4.2.3.4; Evidence={ECO:0000256|HAMAP-Rule:MF_00110,
CC         ECO:0000256|SAAS:SAAS01116881};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00110};
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00110};
CC       Note=Binds 1 divalent metal cation per subunit. Can use either
CC       Co(2+) or Zn(2+). {ECO:0000256|HAMAP-Rule:MF_00110};
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence={ECO:0000256|HAMAP-
CC         Rule:MF_00110, ECO:0000256|SAAS:SAAS00336779};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|SAAS:SAAS00607009};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 2/7. {ECO:0000256|HAMAP-Rule:MF_00110,
CC       ECO:0000256|SAAS:SAAS00210851}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00110,
CC       ECO:0000256|SAAS:SAAS00210934}.
CC   -!- SIMILARITY: Belongs to the sugar phosphate cyclases superfamily.
CC       Dehydroquinate synthase family. {ECO:0000256|HAMAP-Rule:MF_00110,
CC       ECO:0000256|SAAS:SAAS00858850}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00110}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:RJT61195.1}.
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DR   EMBL; BDUU01000002; GBU55489.1; -; Genomic_DNA.
DR   EMBL; BDVO01000001; GBV06616.1; -; Genomic_DNA.
DR   EMBL; BDVT01000001; GBV19341.1; -; Genomic_DNA.
DR   EMBL; BDWF01000002; GBV51239.1; -; Genomic_DNA.
DR   EMBL; BDWV01000002; GBV91852.1; -; Genomic_DNA.
DR   EMBL; BDZP01000001; GBX72202.1; -; Genomic_DNA.
DR   EMBL; BEAD01000002; GBY08447.1; -; Genomic_DNA.
DR   EMBL; BEAN01000001; GBY33483.1; -; Genomic_DNA.
DR   EMBL; BEBF01000001; GBY79533.1; -; Genomic_DNA.
DR   EMBL; BEBG01000002; GBY82276.1; -; Genomic_DNA.
DR   EMBL; BEBY01000002; GBZ28725.1; -; Genomic_DNA.
DR   EMBL; BEBZ01000006; GBZ31715.1; -; Genomic_DNA.
DR   EMBL; BECE01000002; GBZ44258.1; -; Genomic_DNA.
DR   EMBL; BEDM01000003; GCA30268.1; -; Genomic_DNA.
DR   EMBL; JROJ01000011; RIZ62469.1; -; Genomic_DNA.
DR   EMBL; QZVV01000009; RJT61195.1; -; Genomic_DNA.
DR   EMBL; QZVW01000026; RJT70085.1; -; Genomic_DNA.
DR   RefSeq; WP_000776312.1; NZ_UHBV01000001.1.
DR   UniPathway; UPA00053; UER00085.
DR   HAMAP; MF_00110; DHQ_synthase; 1.
DR   InterPro; IPR016037; DHQ_synth_AroB.
DR   InterPro; IPR030963; DHQ_synth_fam.
DR   InterPro; IPR030960; DHQS/DOIS.
DR   Pfam; PF01761; DHQ_synthase; 1.
DR   PIRSF; PIRSF001455; DHQ_synth; 1.
DR   TIGRFAMs; TIGR01357; aroB; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00110,
KW   ECO:0000256|SAAS:SAAS00210890};
KW   Aromatic amino acid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00110,
KW   ECO:0000256|SAAS:SAAS00210867};
KW   Cobalt {ECO:0000256|HAMAP-Rule:MF_00110,
KW   ECO:0000256|SAAS:SAAS00210864};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00110,
KW   ECO:0000256|SAAS:SAAS00210856};
KW   Lyase {ECO:0000256|HAMAP-Rule:MF_00110, ECO:0000256|SAAS:SAAS00958949,
KW   ECO:0000313|EMBL:RJT61195.1};
KW   Metal-binding {ECO:0000256|HAMAP-Rule:MF_00110,
KW   ECO:0000256|SAAS:SAAS01080055};
KW   NAD {ECO:0000256|HAMAP-Rule:MF_00110, ECO:0000256|SAAS:SAAS00210880};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00110,
KW   ECO:0000256|SAAS:SAAS00858852};
KW   Zinc {ECO:0000256|HAMAP-Rule:MF_00110, ECO:0000256|SAAS:SAAS00210870}.
FT   DOMAIN       62    316       DHQ_synthase. {ECO:0000259|Pfam:PF01761}.
FT   NP_BIND     100    104       NAD. {ECO:0000256|HAMAP-Rule:MF_00110}.
FT   NP_BIND     124    125       NAD. {ECO:0000256|HAMAP-Rule:MF_00110}.
FT   NP_BIND     163    166       NAD. {ECO:0000256|HAMAP-Rule:MF_00110}.
FT   METAL       178    178       Cobalt or zinc. {ECO:0000256|HAMAP-Rule:
FT                                MF_00110}.
FT   METAL       242    242       Cobalt or zinc; via tele nitrogen.
FT                                {ECO:0000256|HAMAP-Rule:MF_00110}.
FT   METAL       256    256       Cobalt or zinc; via tele nitrogen.
FT                                {ECO:0000256|HAMAP-Rule:MF_00110}.
FT   BINDING     136    136       NAD; via carbonyl oxygen.
FT                                {ECO:0000256|HAMAP-Rule:MF_00110}.
FT   BINDING     145    145       NAD. {ECO:0000256|HAMAP-Rule:MF_00110}.
SQ   SEQUENCE   354 AA;  40237 MW;  59AB2D0C089B872D CRC64;
     MKLQTTYPSN NYPIFVEHGA IDHISTYIDQ FDQSFILIDE HVNQYFADKF DDILSYENVH
     KVIIPAGEKT KTFEQYQETL EYILSHHVTR NTAIIAVGGG ATGDFAGFVA ATLLRGVHFI
     QVPTTILAHD SSVGGKVGIN SKQGKNLIGA FYRPTAVIYD LDFLKTLPFE QILSGYAEVY
     KHALLNGEST TQEIEQHFKD REILQSLNGM DKYIAKGIET KLDIVVADEK EQGVRKFLNL
     GHTFGHAVEY NHKIAHGHAV MIGIIYQFIV ANILFNSNHD IQHYINYLTK LGYPLETITD
     IDFETIYQYM LSDKKNDKQG VQMVLIKHFG DIVVQHIDQT TLQHACEQLK TYFK
//