ID A0A384X518_9TREM Unreviewed; 118 AA. AC A0A384X518; DT 05-DEC-2018, integrated into UniProtKB/TrEMBL. DT 05-DEC-2018, sequence version 1. DT 13-FEB-2019, entry version 3. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|RuleBase:RU003640, ECO:0000256|SAAS:SAAS01013638}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003640}; GN Name=nad3 {ECO:0000313|EMBL:ATD85502.1}; OS Paragonimus heterotremus. OG Mitochondrion {ECO:0000313|EMBL:ATD85502.1}. OC Eukaryota; Metazoa; Platyhelminthes; Trematoda; Digenea; OC Plagiorchiida; Troglotremata; Troglotrematidae; Paragonimus. OX NCBI_TaxID=100268 {ECO:0000313|EMBL:ATD85502.1}; RN [1] {ECO:0000313|EMBL:ATD85502.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=LC {ECO:0000313|EMBL:ATD85502.1}; RA Le T.H., Do T.R., Nguyen T.K., Nguyen T.B.N., Doan T.T.H., RA Agatsuma T., Blair D.; RT "The near-complete mitochondrial genome of Paragonimus heterotremus RT Chen and Hsia, 1964: comparative mitogenomic insights of the zoonotic RT Paragonimus spp in the family Paragonimidae (Trematoda: RT Platyhelminthes)."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003640, CC ECO:0000256|SAAS:SAAS01013641}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, CC Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, CC ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003640, CC ECO:0000256|SAAS:SAAS01115044}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|SAAS:SAAS01013624}; Multi-pass membrane protein CC {ECO:0000256|SAAS:SAAS01013624}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC {ECO:0000256|RuleBase:RU003640}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY952166; ATD85502.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.58.1610; -; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003640, KW ECO:0000256|SAAS:SAAS01013627}; KW Membrane {ECO:0000256|RuleBase:RU003640}; KW Mitochondrion {ECO:0000256|RuleBase:RU003640, KW ECO:0000256|SAAS:SAAS01013640, ECO:0000313|EMBL:ATD85502.1}; KW NAD {ECO:0000256|RuleBase:RU003640, ECO:0000256|SAAS:SAAS01013636}; KW Respiratory chain {ECO:0000256|RuleBase:RU003640, KW ECO:0000256|SAAS:SAAS01013630}; KW Translocase {ECO:0000256|RuleBase:RU003640, KW ECO:0000256|SAAS:SAAS01099263}; KW Transmembrane {ECO:0000256|RuleBase:RU003640}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003640}; KW Transport {ECO:0000256|RuleBase:RU003640}; KW Ubiquinone {ECO:0000256|RuleBase:RU003640, KW ECO:0000256|SAAS:SAAS01013621}. FT TRANSMEM 57 79 Helical. {ECO:0000256|RuleBase:RU003640}. FT TRANSMEM 91 110 Helical. {ECO:0000256|RuleBase:RU003640}. SQ SEQUENCE 118 AA; 13358 MW; 8AB4EFA1C1850ACD CRC64; MGVLLCGVSL GGLLFFLVCV FHGFFWNVGE GSSSGLRSWV SSFECGFVSQ RGVEDYFSHT YFVLLVFFVI FDLEVSLLLN MPLQGVLYKN LGFYVLFLLL LALGFGIEIY KGYAEWEY //