ID A0A384X518_9TREM Unreviewed; 118 AA. AC A0A384X518; DT 05-DEC-2018, integrated into UniProtKB/TrEMBL. DT 05-DEC-2018, sequence version 1. DT 28-JUN-2023, entry version 17. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|ARBA:ARBA00021007, ECO:0000256|RuleBase:RU003640}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003640}; GN Name=nad3 {ECO:0000313|EMBL:ATD85502.1}; OS Paragonimus heterotremus. OG Mitochondrion {ECO:0000313|EMBL:ATD85502.1}. OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; OC Digenea; Plagiorchiida; Troglotremata; Troglotrematidae; Paragonimus. OX NCBI_TaxID=100268 {ECO:0000313|EMBL:ATD85502.1}; RN [1] {ECO:0000313|EMBL:ATD85502.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=LC {ECO:0000313|EMBL:ATD85502.1}; RA Le T.H., Do T.R., Nguyen T.K., Nguyen T.B.N., Doan T.T.H., Agatsuma T., RA Blair D.; RT "The near-complete mitochondrial genome of Paragonimus heterotremus Chen RT and Hsia, 1964: comparative mitogenomic insights of the zoonotic RT Paragonimus spp in the family Paragonimidae (Trematoda: Platyhelminthes)."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity of complex I. CC {ECO:0000256|RuleBase:RU003640}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU003640}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003640}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003640}. CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY952166; ATD85502.1; -; Genomic_DNA. DR AlphaFoldDB; A0A384X518; -. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.58.1610; NADH:ubiquinone/plastoquinone oxidoreductase, chain 3; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003640}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640}; KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:ATD85502.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640}; KW Respiratory chain {ECO:0000256|RuleBase:RU003640}; KW Translocase {ECO:0000256|RuleBase:RU003640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003640}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003640}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640}; KW Ubiquinone {ECO:0000256|RuleBase:RU003640}. FT TRANSMEM 57..79 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" FT TRANSMEM 91..110 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" SQ SEQUENCE 118 AA; 13358 MW; 8AB4EFA1C1850ACD CRC64; MGVLLCGVSL GGLLFFLVCV FHGFFWNVGE GSSSGLRSWV SSFECGFVSQ RGVEDYFSHT YFVLLVFFVI FDLEVSLLLN MPLQGVLYKN LGFYVLFLLL LALGFGIEIY KGYAEWEY //