ID A0A384X518_9TREM Unreviewed; 118 AA. AC A0A384X518; DT 05-DEC-2018, integrated into UniProtKB/TrEMBL. DT 05-DEC-2018, sequence version 1. DT 07-APR-2021, entry version 10. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000256|RuleBase:RU003640}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003640}; GN Name=nad3 {ECO:0000313|EMBL:ATD85502.1}; OS Paragonimus heterotremus. OG Mitochondrion {ECO:0000313|EMBL:ATD85502.1}. OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda; OC Digenea; Plagiorchiida; Troglotremata; Troglotrematidae; Paragonimus. OX NCBI_TaxID=100268 {ECO:0000313|EMBL:ATD85502.1}; RN [1] {ECO:0000313|EMBL:ATD85502.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=LC {ECO:0000313|EMBL:ATD85502.1}; RA Le T.H., Do T.R., Nguyen T.K., Nguyen T.B.N., Doan T.T.H., Agatsuma T., RA Blair D.; RT "The near-complete mitochondrial genome of Paragonimus heterotremus Chen RT and Hsia, 1964: comparative mitogenomic insights of the zoonotic RT Paragonimus spp in the family Paragonimidae (Trematoda: Platyhelminthes)."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|RuleBase:RU003640}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU003640}; CC -!- SIMILARITY: Belongs to the complex I subunit 3 family. CC {ECO:0000256|ARBA:ARBA00008472, ECO:0000256|RuleBase:RU003640}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY952166; ATD85502.1; -; Genomic_DNA. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR Gene3D; 1.20.58.1610; -; 1. DR InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3. DR InterPro; IPR038430; NDAH_ubi_oxred_su3_sf. DR Pfam; PF00507; Oxidored_q4; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003640}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003640}; KW Mitochondrion {ECO:0000256|RuleBase:RU003640, ECO:0000313|EMBL:ATD85502.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003640}; KW Respiratory chain {ECO:0000256|RuleBase:RU003640}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003640}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU003640}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU003640}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003640}; KW Ubiquinone {ECO:0000256|RuleBase:RU003640}. FT TRANSMEM 57..79 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" FT TRANSMEM 91..110 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU003640" SQ SEQUENCE 118 AA; 13358 MW; 8AB4EFA1C1850ACD CRC64; MGVLLCGVSL GGLLFFLVCV FHGFFWNVGE GSSSGLRSWV SSFECGFVSQ RGVEDYFSHT YFVLLVFFVI FDLEVSLLLN MPLQGVLYKN LGFYVLFLLL LALGFGIEIY KGYAEWEY //