ID A0A384NPX1_HUMAN Unreviewed; 470 AA. AC A0A384NPX1; DT 05-DEC-2018, integrated into UniProtKB/TrEMBL. DT 05-DEC-2018, sequence version 1. DT 02-OCT-2024, entry version 21. DE RecName: Full=Desmin {ECO:0000256|ARBA:ARBA00040601}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606 {ECO:0000313|EMBL:ADO22408.1}; RN [1] {ECO:0000313|EMBL:ADO22408.1} RP NUCLEOTIDE SEQUENCE. RA Hoernsten L., Su C., Osbourn A.E., Hellman U., Wernstedt C., Oliw E.H.; RL Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane, sarcolemma CC {ECO:0000256|ARBA:ARBA00004135}. Cell tip CC {ECO:0000256|ARBA:ARBA00044500}. Cytoplasm, myofibril, sarcomere, Z CC line {ECO:0000256|ARBA:ARBA00004216}. Nucleus envelope CC {ECO:0000256|ARBA:ARBA00004259}. CC -!- SIMILARITY: Belongs to the intermediate filament family. CC {ECO:0000256|RuleBase:RU000685}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; GQ900891; ADO22408.1; -; mRNA. DR AlphaFoldDB; A0A384NPX1; -. DR PeptideAtlas; A0A384NPX1; -. DR GO; GO:0051286; C:cell tip; IEA:UniProtKB-SubCell. DR GO; GO:0005911; C:cell-cell junction; IEA:TreeGrafter. DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW. DR GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell. DR GO; GO:0042383; C:sarcolemma; IEA:UniProtKB-SubCell. DR GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell. DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:TreeGrafter. DR GO; GO:0045109; P:intermediate filament organization; IEA:TreeGrafter. DR GO; GO:0060538; P:skeletal muscle organ development; IEA:TreeGrafter. DR Gene3D; 1.20.5.170; -; 1. DR Gene3D; 1.20.5.500; Single helix bin; 1. DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1. DR InterPro; IPR018039; IF_conserved. DR InterPro; IPR039008; IF_rod_dom. DR InterPro; IPR006821; Intermed_filament_DNA-bd. DR InterPro; IPR050405; Intermediate_filament. DR PANTHER; PTHR45652:SF2; DESMIN; 1. DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1. DR Pfam; PF00038; Filament; 1. DR Pfam; PF04732; Filament_head; 1. DR SMART; SM01391; Filament; 1. DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2. DR PROSITE; PS00226; IF_ROD_1; 1. DR PROSITE; PS51842; IF_ROD_2; 1. PE 2: Evidence at transcript level; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490}; KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754, KW ECO:0000256|RuleBase:RU000685}; Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Muscle protein {ECO:0000256|ARBA:ARBA00023179}. FT DOMAIN 108..416 FT /note="IF rod" FT /evidence="ECO:0000259|PROSITE:PS51842" FT COILED 105..267 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 300..394 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 470 AA; 53554 MW; 1B5D9EAE51FBB319 CRC64; MSQAYSSSQR VSSYRRTFGG APGFPLGSPL SSPVFPRAGF GSKGSSSSVT SRVYQVSRTS GGAGGLGSLR ASRLGTTRTP SSYGAGELLD FSLADAVNQE FLTTRTNEKV ELQELNDRFA NYIEKVRFLE QQNAALAAEV NRLKGREPTR VAELYEEELR ELRRQVEVLT NQRARVDVER DNLLDDLQRL KAKLQEEIQL KEEAENNLAA FRADVDAATL ARIDLERRIE SLNEEIAFLK KVHEEEIREL QAQLQEQQVQ VEMDMSKPDL TAALRDIRAQ YETIAAKNIS EAEEWYKSKV SDLTQAANKN NDALRQAKQE MMEYRHQIQS YTCEIDALKG TNDSLMRQMR ELEDRFASEA SGYQDNIARL EEEIRHLKDE MARHLREYQD LLNVKMALDV EIATYRKLLE GEESRINLPI QTYSALNFRE TSPEQRGSEV HTKKTVMIKT METRDGEVVS EATQQQHEVL //