ID   A0A384DPX9_URSMA        Unreviewed;       285 AA.
AC   A0A384DPX9;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   19-JAN-2022, entry version 17.
DE   RecName: Full=CCR4-NOT transcription complex subunit 7 {ECO:0000256|ARBA:ARBA00014176};
DE            EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161};
DE   AltName: Full=CCR4-associated factor 1 {ECO:0000256|ARBA:ARBA00016909};
GN   Name=CNOT7 {ECO:0000313|Ensembl:ENSUMAP00000028376,
GN   ECO:0000313|RefSeq:XP_008709117.1};
OS   Ursus maritimus (Polar bear) (Thalarctos maritimus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus.
OX   NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008709117.1};
RN   [1] {ECO:0000313|Proteomes:UP000291021}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=24813606; DOI=10.1016/j.cell.2014.03.054;
RA   Liu S., Lorenzen E.D., Fumagalli M., Li B., Harris K., Xiong Z., Zhou L.,
RA   Korneliussen T.S., Somel M., Babbitt C., Wray G., Li J., He W., Wang Z.,
RA   Fu W., Xiang X., Morgan C.C., Doherty A., O'Connell M.J., McInerney J.O.,
RA   Born E.W., Dalen L., Dietz R., Orlando L., Sonne C., Zhang G., Nielsen R.,
RA   Willerslev E., Wang J.;
RT   "Population genomics reveal recent speciation and rapid evolutionary
RT   adaptation in polar bears.";
RL   Cell 157:785-794(2014).
RN   [2] {ECO:0000313|Ensembl:ENSUMAP00000028376}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (MAR-2019) to UniProtKB.
RN   [3] {ECO:0000313|RefSeq:XP_008709117.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle sample {ECO:0000313|RefSeq:XP_008709117.1};
RG   RefSeq;
RL   Submitted (FEB-2021) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00001663};
CC   -!- COFACTOR:
CC       Name=Co(2+); Xref=ChEBI:CHEBI:48828;
CC         Evidence={ECO:0000256|ARBA:ARBA00001941};
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
CC   -!- COFACTOR:
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|ARBA:ARBA00001936};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the CAF1 family.
CC       {ECO:0000256|ARBA:ARBA00008372}.
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DR   RefSeq; XP_008709117.1; XM_008710895.1.
DR   STRING; 29073.XP_008709117.1; -.
DR   Ensembl; ENSUMAT00000033570; ENSUMAP00000028376; ENSUMAG00000020629.
DR   GeneID; 103681341; -.
DR   KEGG; umr:103681341; -.
DR   CTD; 29883; -.
DR   GeneTree; ENSGT00390000000080; -.
DR   OMA; DTKWISF; -.
DR   Proteomes; UP000261680; Genome assembly.
DR   Proteomes; UP000291021; Unassembled WGS sequence.
DR   GO; GO:0030014; C:CCR4-NOT complex; IEA:Ensembl.
DR   GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR   GO; GO:0000932; C:P-body; IEA:Ensembl.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IEA:Ensembl.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR   GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:Ensembl.
DR   GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR   GO; GO:0043928; P:exonucleolytic catabolism of deadenylated mRNA; IEA:Ensembl.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:Ensembl.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl.
DR   GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR   GO; GO:0033962; P:P-body assembly; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; IEA:Ensembl.
DR   GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl.
DR   GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl.
DR   Gene3D; 3.30.420.10; -; 1.
DR   InterPro; IPR039636; CNOT7.
DR   InterPro; IPR039637; CNOT7/CNOT8/Pop2.
DR   InterPro; IPR006941; RNase_CAF1.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR10797; PTHR10797; 1.
DR   PANTHER; PTHR10797:SF2; PTHR10797:SF2; 1.
DR   Pfam; PF04857; CAF1; 2.
DR   SUPFAM; SSF53098; SSF53098; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000261680};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW   Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
SQ   SEQUENCE   285 AA;  32745 MW;  2AF23ED27E06EFDB CRC64;
     MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY
     QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG
     IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD
     FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK
     MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS
//