ID A0A384DPX9_URSMA Unreviewed; 285 AA. AC A0A384DPX9; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 02-DEC-2020, entry version 12. DE RecName: Full=CCR4-NOT transcription complex subunit 7 {ECO:0000256|ARBA:ARBA00014176}; DE EC=3.1.13.4 {ECO:0000256|ARBA:ARBA00012161}; DE AltName: Full=CCR4-associated factor 1 {ECO:0000256|ARBA:ARBA00016909}; GN Name=CNOT7 {ECO:0000313|Ensembl:ENSUMAP00000028376, GN ECO:0000313|RefSeq:XP_008709117.1}; OS Ursus maritimus (Polar bear) (Thalarctos maritimus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ursus. OX NCBI_TaxID=29073 {ECO:0000313|Proteomes:UP000261680, ECO:0000313|RefSeq:XP_008709117.1}; RN [1] {ECO:0000313|Ensembl:ENSUMAP00000028376} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=24813606; DOI=10.1016/j.cell.2014.03.054; RA Liu S., Lorenzen E.D., Fumagalli M., Li B., Harris K., Xiong Z., Zhou L., RA Korneliussen T.S., Somel M., Babbitt C., Wray G., Li J., He W., Wang Z., RA Fu W., Xiang X., Morgan C.C., Doherty A., O'Connell M.J., McInerney J.O., RA Born E.W., Dalen L., Dietz R., Orlando L., Sonne C., Zhang G., Nielsen R., RA Willerslev E., Wang J.; RT "Population genomics reveal recent speciation and rapid evolutionary RT adaptation in polar bears."; RL Cell 157:785-794(2014). RN [2] {ECO:0000313|RefSeq:XP_008709117.1} RP IDENTIFICATION. RC TISSUE=Muscle sample {ECO:0000313|RefSeq:XP_008709117.1}; RG RefSeq; RL Submitted (SEP-2018) to UniProtKB. RN [3] {ECO:0000313|Ensembl:ENSUMAP00000028376} RP IDENTIFICATION. RG Ensembl; RL Submitted (MAR-2019) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=Exonucleolytic cleavage of poly(A) to 5'-AMP.; EC=3.1.13.4; CC Evidence={ECO:0000256|ARBA:ARBA00001663}; CC -!- COFACTOR: CC Name=Co(2+); Xref=ChEBI:CHEBI:48828; CC Evidence={ECO:0000256|ARBA:ARBA00001941}; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; CC Evidence={ECO:0000256|ARBA:ARBA00001946}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}. CC -!- SIMILARITY: Belongs to the CAF1 family. CC {ECO:0000256|ARBA:ARBA00008372}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_008709117.1; XM_008710895.1. DR SMR; A0A384DPX9; -. DR Ensembl; ENSUMAT00000033570; ENSUMAP00000028376; ENSUMAG00000020629. DR GeneID; 103681341; -. DR KEGG; umr:103681341; -. DR CTD; 29883; -. DR GeneTree; ENSGT00390000000080; -. DR OMA; MPSNEEC; -. DR Proteomes; UP000261680; Genome assembly. DR Proteomes; UP000291021; Unassembled WGS sequence. DR GO; GO:0030014; C:CCR4-NOT complex; IEA:Ensembl. DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl. DR GO; GO:0000932; C:P-body; IEA:Ensembl. DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro. DR GO; GO:0004535; F:poly(A)-specific ribonuclease activity; IEA:UniProtKB-EC. DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl. DR GO; GO:0008134; F:transcription factor binding; IEA:Ensembl. DR GO; GO:0000290; P:deadenylation-dependent decapping of nuclear-transcribed mRNA; IEA:Ensembl. DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl. DR GO; GO:0043928; P:exonucleolytic catabolism of deadenylated mRNA; IEA:Ensembl. DR GO; GO:0031047; P:gene silencing by RNA; IEA:Ensembl. DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl. DR GO; GO:0060339; P:negative regulation of type I interferon-mediated signaling pathway; IEA:Ensembl. DR GO; GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl. DR GO; GO:0033962; P:P-body assembly; IEA:Ensembl. DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl. DR GO; GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; IEA:Ensembl. DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0045070; P:positive regulation of viral genome replication; IEA:Ensembl. DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. DR GO; GO:0042509; P:regulation of tyrosine phosphorylation of STAT protein; IEA:Ensembl. DR Gene3D; 3.30.420.10; -; 1. DR InterPro; IPR039636; CNOT7. DR InterPro; IPR039637; CNOT7/CNOT8/Pop2. DR InterPro; IPR006941; RNase_CAF1. DR InterPro; IPR012337; RNaseH-like_sf. DR InterPro; IPR036397; RNaseH_sf. DR PANTHER; PTHR10797; PTHR10797; 1. DR PANTHER; PTHR10797:SF2; PTHR10797:SF2; 1. DR Pfam; PF04857; CAF1; 2. DR SUPFAM; SSF53098; SSF53098; 1. PE 3: Inferred from homology; KW Reference proteome {ECO:0000313|Proteomes:UP000261680}; KW Repressor {ECO:0000256|ARBA:ARBA00022491}; KW Transcription {ECO:0000256|ARBA:ARBA00023163}; KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}; KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}. SQ SEQUENCE 285 AA; 32745 MW; 2AF23ED27E06EFDB CRC64; MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ DSIELLTTSG IQFKKHEEEG IETQYFAELL MTSGVVLCEG VKWLSFHSGY DFGYLIKILT NSNLPEEELD FFEILRLFFP VIYDVKYLMK SCKNLKGGLQ EVAEQLELER IGPQHQAGSD SLLTGMAFFK MREMFFEDHI DDAKYCGHLY GLGSGSSYVQ NGTGNAYEEE ANKQS //