ID A0A381A9B9_BRAPL Unreviewed; 419 AA. AC A0A381A9B9; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 05-DEC-2018, entry version 2. DE RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579}; DE EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579}; GN Name=hom {ECO:0000313|EMBL:SUW07762.1}; GN ORFNames=NCTC13046_00521 {ECO:0000313|EMBL:SUW07762.1}; OS Brachyspira pilosicoli. OC Bacteria; Spirochaetes; Brachyspirales; Brachyspiraceae; Brachyspira. OX NCBI_TaxID=52584 {ECO:0000313|EMBL:SUW07762.1, ECO:0000313|Proteomes:UP000254237}; RN [1] {ECO:0000313|EMBL:SUW07762.1, ECO:0000313|Proteomes:UP000254237} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC13046 {ECO:0000313|EMBL:SUW07762.1, RC ECO:0000313|Proteomes:UP000254237}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4- CC semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:537519, ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, CC ChEBI:CHEBI:58349; EC=1.1.1.3; CC Evidence={ECO:0000256|RuleBase:RU000579}; CC -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de CC novo pathway; L-homoserine from L-aspartate: step 3/3. CC {ECO:0000256|RuleBase:RU000579}. CC -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L- CC threonine from L-aspartate: step 3/5. CC {ECO:0000256|RuleBase:RU000579}. CC -!- SIMILARITY: Belongs to the homoserine dehydrogenase family. CC {ECO:0000256|RuleBase:RU004171}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; UFTN01000001; SUW07762.1; -; Genomic_DNA. DR RefSeq; WP_013243025.1; NZ_UFTP01000003.1. DR UniPathway; UPA00050; UER00063. DR UniPathway; UPA00051; UER00465. DR Proteomes; UP000254237; Unassembled WGS sequence. DR GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC. DR InterPro; IPR005106; Asp/hSer_DH_NAD-bd. DR InterPro; IPR016204; HDH. DR InterPro; IPR001342; HDH_cat. DR InterPro; IPR019811; HDH_CS. DR InterPro; IPR036291; NAD(P)-bd_dom_sf. DR Pfam; PF00742; Homoserine_dh; 1. DR Pfam; PF03447; NAD_binding_3; 1. DR PIRSF; PIRSF000098; Homoser_dehydrog; 1. DR SUPFAM; SSF51735; SSF51735; 1. DR PROSITE; PS01042; HOMOSER_DHGENASE; 1. PE 3: Inferred from homology; KW Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579}; KW Branched-chain amino acid biosynthesis KW {ECO:0000256|RuleBase:RU000579}; KW Complete proteome {ECO:0000313|Proteomes:UP000254237}; KW Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579}; KW Methionine biosynthesis {ECO:0000256|RuleBase:RU000579}; KW NADP {ECO:0000256|RuleBase:RU000579}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000579, KW ECO:0000313|EMBL:SUW07762.1}; KW Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}. FT DOMAIN 13 118 NAD_binding_3. {ECO:0000259|Pfam: FT PF03447}. FT DOMAIN 135 314 Homoserine_dh. {ECO:0000259|Pfam: FT PF00742}. SQ SEQUENCE 419 AA; 46701 MW; 04B673E1A2CC4F15 CRC64; MNESKEIKIA IAGYGNVGKG TLKTIITNNK SIERRSGFKL IVKTVFSRNI KEKHDEYLDT VENKTEDLND ILNDNEIDII VEVLGGMTTA KELILKSTKP IVTANKALLA NSLEELIKDR KSDIEFEASV AGAIPIIRAM KESLTADNIE SISGILNGTC NYILTNMTKQ KIDFNVVLKE AQDKGYAEAD PTFDIDGIDT AHKICILASM AFCNIINMKD IYIRGIRNIL LDDIIFAMGL GYTVKLVADA SIDKDNNLYV YVIPSFIKDR NFLARTSYSF NAIKITSDIA GDNVFYGVGA GGINTSSAIV SDIISIAKNK AISNELFSPI LGFSNYNNDL VIKDFRDKEE DFYVRFKSLK NKIDSFVNAF NNSSINVDKT LNKDNNMMFI LRKTTINNIL NSIKTVEDIE NIFIAKIKH //