ID A0A380G394_STAIN Unreviewed; 464 AA. AC A0A380G394; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 02-JUN-2021, entry version 12. DE SubName: Full=Transporter protein {ECO:0000313|EMBL:SUM45619.1}; GN Name=emrB_1 {ECO:0000313|EMBL:SUM45619.1}; GN ORFNames=NCTC11048_00606 {ECO:0000313|EMBL:SUM45619.1}; OS Staphylococcus intermedius NCTC 11048. OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; OC Staphylococcus; Staphylococcus intermedius group. OX NCBI_TaxID=1141106 {ECO:0000313|EMBL:SUM45619.1, ECO:0000313|Proteomes:UP000255549}; RN [1] {ECO:0000313|EMBL:SUM45619.1, ECO:0000313|Proteomes:UP000255549} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC 11048 {ECO:0000313|Proteomes:UP000255549}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651}; CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the major facilitator superfamily. EmrB family. CC {ECO:0000256|ARBA:ARBA00008537}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; UHDP01000003; SUM45619.1; -; Genomic_DNA. DR RefSeq; WP_019168910.1; NZ_UHDP01000003.1. DR EnsemblBacteria; SUM45619; SUM45619; NCTC11048_00606. DR Proteomes; UP000255549; Unassembled WGS sequence. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro. DR InterPro; IPR004638; EmrB-like. DR InterPro; IPR011701; MFS. DR InterPro; IPR020846; MFS_dom. DR InterPro; IPR036259; MFS_trans_sf. DR Pfam; PF07690; MFS_1; 1. DR SUPFAM; SSF103473; SSF103473; 1. DR TIGRFAMs; TIGR00711; efflux_EmrB; 1. DR PROSITE; PS50850; MFS; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}. FT TRANSMEM 12..34 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 54..73 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 82..105 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 111..132 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 139..162 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 168..188 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 200..220 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 232..249 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 269..293 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 305..322 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 334..353 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 359..385 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 406..428 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 440..459 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 16..464 FT /note="MFS" FT /evidence="ECO:0000259|PROSITE:PS50850" SQ SEQUENCE 464 AA; 50876 MW; 11806B8AEEFC0CB5 CRC64; MSGSTYHHSI QQHLPAIVIM ISGAFIAVLN QTLFSTVLPE IMADFQLTSS EAQWVTTIFM LVNGIMIPVT AYLSQRFTLR RLFFTALTLF LIGSLLGMLA PNYIFVLVGR AIQAMGAGIL MPLTQTFLFL VFPIEKRGMA MGLFGLVIGF APAIGPTASG WFVNLFNWRY LFLIILVITM IVLILGIFKM TNATELSHPS LDILSVILST LGFGGLLFGF SLAGQYGWGN PLSYVTIIVA LIILTLFVFR QLRLESPMLE MRVFLHRSFT VPIALVVLMF LIFIGTMTML PIYMQSMRGM SPLQSGLVLL PGGLVMGLLA PMNGRLYDNI GGRILAVTGM SFIFIGTVMI SFLNETSPVW YIILSFVILT FGNSGIMVPM TTEAMNALPK SLIPHGTAMN NTLRQISAAI GTGLLVTVMS QIAMAHGGDQ VMRNIFGLQW TYRIVALIVV FGLLVATRVS KKPT //