ID   A0A379D6X2_PLUGE        Unreviewed;       374 AA.
AC   A0A379D6X2;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   22-FEB-2023, entry version 12.
DE   RecName: Full=site-specific DNA-methyltransferase (cytosine-N(4)-specific) {ECO:0000256|ARBA:ARBA00012185};
DE            EC=2.1.1.113 {ECO:0000256|ARBA:ARBA00012185};
GN   ORFNames=NCTC11434_05122 {ECO:0000313|EMBL:SUB73609.1};
OS   Pluralibacter gergoviae (Enterobacter gergoviae).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Pluralibacter.
OX   NCBI_TaxID=61647 {ECO:0000313|EMBL:SUB73609.1, ECO:0000313|Proteomes:UP000254381};
RN   [1] {ECO:0000313|EMBL:SUB73609.1, ECO:0000313|Proteomes:UP000254381}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC11434 {ECO:0000313|EMBL:SUB73609.1,
RC   ECO:0000313|Proteomes:UP000254381};
RG   Pathogen Informatics;
RA   Doyle S.;
RL   Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = an N(4)-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:16857, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:13674,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:137933; EC=2.1.1.113;
CC         Evidence={ECO:0000256|ARBA:ARBA00001893};
CC   -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family. N(4)
CC       subfamily. {ECO:0000256|ARBA:ARBA00010203}.
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DR   EMBL; UGTG01000002; SUB73609.1; -; Genomic_DNA.
DR   RefSeq; WP_048253774.1; NZ_LR699009.1.
DR   AlphaFoldDB; A0A379D6X2; -.
DR   REBASE; 405590; M.Pge11434ORF5122P.
DR   EnsemblBacteria; SUB73609; SUB73609; NCTC11434_05122.
DR   GeneID; 61381899; -.
DR   Proteomes; UP000254381; Unassembled WGS sequence.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0015667; F:site-specific DNA-methyltransferase (cytosine-N4-specific) activity; IEA:UniProtKB-EC.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR002941; DNA_methylase_N4/N6.
DR   InterPro; IPR017985; MeTrfase_CN4_CS.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF01555; N6_N4_Mtase; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR   PROSITE; PS00093; N4_MTASE; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000313|EMBL:SUB73609.1};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          14..71
FT                   /note="DNA methylase N-4/N-6"
FT                   /evidence="ECO:0000259|Pfam:PF01555"
SQ   SEQUENCE   374 AA;  41902 MW;  F2403D4C1DB847D8 CRC64;
     MALAYRKENA LNAICPYFTM FPLEYPNKII KKYKKQRPVV LDPFCGRGTT LFSARTFGVS
     AWGIDSSPVA VAVARAKLAS CDPMSPIELA ENILSKVDPN KIPNTPFFRV AYHSDTLRDI
     CALREGLSKL PLDTDSSVIL RAAILGALHG PLARNIDNMS YFSNQMPRTY ASKPDYAVRF
     WSERGMSPPK VDVLRVLRRK IERLVGLSSG IPDTFKQVIQ GDSRSADVFQ SLNMRPSLII
     TSPPYYGMKT YVQDQWLRNW FLGGPESVDY SSGSQLDHSG KDTFSKSLGE VWRNIAKCAS
     ESNDLHMYVR FGIIPSASVN AKEIFRNSLE ESNILWRLIS VRAADSAEAG KRQAHQMRTG
     SSAAIEYDFH VERI
//