ID A0A378B7X7_KLEPN Unreviewed; 117 AA. AC A0A378B7X7; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 12-AUG-2020, entry version 7. DE RecName: Full=Aspartate carbamoyltransferase catalytic subunit {ECO:0000256|ARBA:ARBA00015070}; DE EC=2.1.3.2 {ECO:0000256|ARBA:ARBA00013008}; DE AltName: Full=Aspartate transcarbamylase {ECO:0000256|ARBA:ARBA00015628}; GN Name=pyrB_1 {ECO:0000313|EMBL:STV31031.1}; GN Synonyms=pyrB_2 {ECO:0000313|EMBL:STV70889.1}; GN ORFNames=NCTC11679_05109 {ECO:0000313|EMBL:STV70889.1}, NCTC5053_03953 GN {ECO:0000313|EMBL:STV31031.1}; OS Klebsiella pneumoniae. OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:STV31031.1, ECO:0000313|Proteomes:UP000254387}; RN [1] {ECO:0000313|EMBL:STV31031.1, ECO:0000313|Proteomes:UP000254387, ECO:0000313|Proteomes:UP000255239} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC11679 {ECO:0000313|EMBL:STV70889.1, RC ECO:0000313|Proteomes:UP000255239}, and NCTC5053 RC {ECO:0000313|EMBL:STV31031.1, ECO:0000313|Proteomes:UP000254387}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L- CC aspartate + phosphate; Xref=Rhea:RHEA:20013, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:29991, ChEBI:CHEBI:32814, ChEBI:CHEBI:43474, CC ChEBI:CHEBI:58228; EC=2.1.3.2; CC Evidence={ECO:0000256|ARBA:ARBA00001363}; CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; CC (S)-dihydroorotate from bicarbonate: step 2/3. CC {ECO:0000256|ARBA:ARBA00004852}. CC -!- SIMILARITY: Belongs to the aspartate/ornithine carbamoyltransferase CC superfamily. {ECO:0000256|RuleBase:RU003634}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; UGMN01000004; STV31031.1; -; Genomic_DNA. DR EMBL; UGMG01000001; STV70889.1; -; Genomic_DNA. DR UniPathway; UPA00070; UER00116. DR Proteomes; UP000254387; Unassembled WGS sequence. DR Proteomes; UP000255239; Unassembled WGS sequence. DR GO; GO:0016597; F:amino acid binding; IEA:InterPro. DR GO; GO:0004070; F:aspartate carbamoyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro. DR GO; GO:0006520; P:cellular amino acid metabolic process; IEA:InterPro. DR Gene3D; 3.40.50.1370; -; 1. DR InterPro; IPR006130; Asp/Orn_carbamoylTrfase. DR InterPro; IPR036901; Asp/Orn_carbamoylTrfase_sf. DR InterPro; IPR002082; Asp_carbamoyltransf. DR InterPro; IPR006131; Asp_carbamoyltransf_Asp/Orn-bd. DR PANTHER; PTHR11405:SF16; PTHR11405:SF16; 1. DR Pfam; PF00185; OTCace; 1. DR PRINTS; PR00100; AOTCASE. DR SUPFAM; SSF53671; SSF53671; 1. PE 3: Inferred from homology; KW Pyrimidine biosynthesis {ECO:0000256|ARBA:ARBA00022975}; KW Transferase {ECO:0000256|RuleBase:RU003634, ECO:0000313|EMBL:STV31031.1}. FT DOMAIN 10..109 FT /note="OTCace" FT /evidence="ECO:0000259|Pfam:PF00185" SQ SEQUENCE 117 AA; 13225 MW; 11CD42CF3D5DBB53 CRC64; MPQYILDMLD EKGIAWSLHS AIDDVMAEVD ILYMTRVQKE RLDPSEYANV KAQFVLRAAD LEGARANMKV LHPLPRIDEI TTDVDKTPHA WYFQQAGNGI FARQALLALV LNSELAL //