ID A0A355VGS7_9BACT Unreviewed; 343 AA. AC A0A355VGS7; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 03-AUG-2022, entry version 16. DE RecName: Full=Cell shape-determining protein MreB {ECO:0000256|HAMAP-Rule:MF_02207}; GN Name=mreB {ECO:0000256|HAMAP-Rule:MF_02207}; GN ORFNames=DD422_06120 {ECO:0000313|EMBL:HBN17608.1}; OS Akkermansia sp. OC Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales; OC Akkermansiaceae; Akkermansia. OX NCBI_TaxID=1872421 {ECO:0000313|EMBL:HBN17608.1, ECO:0000313|Proteomes:UP000262786}; RN [1] {ECO:0000313|EMBL:HBN17608.1, ECO:0000313|Proteomes:UP000262786} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UBA11944 {ECO:0000313|EMBL:HBN17608.1}; RX PubMed=30148503; DOI=.1038/nbt.4229; RA Parks D.H., Chuvochina M., Waite D.W., Rinke C., Skarshewski A., RA Chaumeil P.A., Hugenholtz P.; RT "A standardized bacterial taxonomy based on genome phylogeny substantially RT revises the tree of life."; RL Nat. Biotechnol. 36:996-1004(2018). CC -!- FUNCTION: Forms membrane-associated dynamic filaments that are CC essential for cell shape determination. Acts by regulating cell wall CC synthesis and cell elongation, and thus cell shape. A feedback loop CC between cell geometry and MreB localization may maintain elongated cell CC shape by targeting cell wall growth to regions of negative cell wall CC curvature. {ECO:0000256|HAMAP-Rule:MF_02207}. CC -!- SUBUNIT: Forms polymers. {ECO:0000256|HAMAP-Rule:MF_02207}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02207}. CC Note=Membrane-associated. {ECO:0000256|HAMAP-Rule:MF_02207}. CC -!- SIMILARITY: Belongs to the FtsA/MreB family. CC {ECO:0000256|ARBA:ARBA00023458, ECO:0000256|HAMAP-Rule:MF_02207}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:HBN17608.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DOBZ01000136; HBN17608.1; -; Genomic_DNA. DR Proteomes; UP000262786; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0000902; P:cell morphogenesis; IEA:InterPro. DR GO; GO:0008360; P:regulation of cell shape; IEA:UniProtKB-UniRule. DR CDD; cd10225; MreB_like; 1. DR HAMAP; MF_02207; MreB; 1. DR InterPro; IPR043129; ATPase_NBD. DR InterPro; IPR004753; MreB. DR PRINTS; PR01652; SHAPEPROTEIN. DR SUPFAM; SSF53067; SSF53067; 2. DR TIGRFAMs; TIGR00904; mreB; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|HAMAP-Rule:MF_02207}; KW Cell shape {ECO:0000256|HAMAP-Rule:MF_02207}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_02207}; KW Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_02207}. FT BINDING 22..24 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207" FT BINDING 164..166 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207" FT BINDING 212..215 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207" FT BINDING 292..295 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_02207" SQ SEQUENCE 343 AA; 37013 MW; 55193B84952A9F36 CRC64; MSSFFQKIVK LFSYDIGIDL GTANTLVNVK DQGIVLREPS VVAVKGDKVL AVGDEAKRML GRTPGSVTAI RPLKDGVIAD FYITEEMLRY FIKKATARYY LIKPRVLIAI PSGITEVERR AVKESAEAAG ARRVHLIEEP MAAAIGVGLP VQEAAGNMIV DIGGGTTEVA LISLSGIVYS RSVRCAGDEL DDAIISYMRR TYNLMVGERT AEDIKIRIGS AYPLPQELSI EVKGRDLVAG LPKTVTIRSE EVREALTEQL NTIVDAVRTT LERCPPELAA DLVDRGIVLA GGGALLRGLD QLLHDQTGLP IHIAEDPLSA VAEGTGKALQ ELDFFTNVTD AED //