ID   A0A346G274_9HIV1        Unreviewed;       435 AA.
AC   A0A346G274;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   12-AUG-2020, entry version 9.
DE   RecName: Full=Protease {ECO:0000256|ARBA:ARBA00016591};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
DE   AltName: Full=Retropepsin {ECO:0000256|ARBA:ARBA00019041};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AXN89387.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AXN89387.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AXN89387.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=KYR_Bishkek91 {ECO:0000313|EMBL:AXN89387.1};
RA   Totmenin A.V., Ivlev V.V., Astakhova E.M., Zyryanova D.P., Sokolova O.O.,
RA   Gashnikova M.P., Bekbolotov A.A., Akbekov B.M., Kadyrbekov U.K.,
RA   Gashnikova N.M.;
RT   "HIV-1 Genetic Diversity and Drug Resistance in Bishkek region of
RT   Kyrgyzstan.";
RL   Submitted (JAN-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the retroviral Pol polyprotein family.
CC       {ECO:0000256|RuleBase:RU004064}.
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DR   EMBL; MG798970; AXN89387.1; -; Genomic_DNA.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   CDD; cd05482; HIV_retropepsin_like; 1.
DR   Gene3D; 2.40.70.10; -; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR001995; Peptidase_A2_cat.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR034170; Retropepsin-like_cat_dom.
DR   InterPro; IPR018061; Retropepsins.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR010661; RVT_thumb.
DR   Pfam; PF00077; RVP; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   Pfam; PF06817; RVT_thumb; 1.
DR   SUPFAM; SSF50630; SSF50630; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50175; ASP_PROT_RETROV; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 1.
DR   PROSITE; PS50878; RT_POL; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|ARBA:ARBA00022750,
KW   ECO:0000256|RuleBase:RU004064};
KW   DNA integration {ECO:0000256|ARBA:ARBA00023195};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU004064};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|RuleBase:RU004064};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          66..135
FT                   /note="Peptidase A2"
FT                   /evidence="ECO:0000259|PROSITE:PS50175"
FT   DOMAIN          189..379
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|PROSITE:PS50878"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AXN89387.1"
FT   NON_TER         435
FT                   /evidence="ECO:0000313|EMBL:AXN89387.1"
SQ   SEQUENCE   435 AA;  49405 MW;  35A9E1D66B58A586 CRC64;
     REARKFSSEQ TRTISPTSRE LWDGGRDNPL PETRTERQGT AASFNFPQIT LWQRPLVTVR
     VGGQVKEALL DTGADDTVLE DIDLPGKWKP KMIGGIGGFI KVKQYDQILI EICGKRAIGT
     VLIGPTPVNI IGRNMLTQIG CTLNFPISPI ETVPVALKPG MDGPKVKQWP LTEEKIKALT
     EICMEMEKEG KISKIGPENP YNTPIFAIKK KDGTKWRKLV DFRELNKRTQ DFWEVQLGIP
     HPAGLKRQRS VTVLDVGDAY FSVPLDESFR KYTAFTIPST NNETPGIRYQ YNVLPQGWKG
     SPAIFQSSMT KILEPFRLKN PEIVIYQYMD DLYVGSDLEI GQHRIKIEEL RAHLLSWGFT
     TPDKKHQKEP PFLWMGYELH PDKWTVQPIV LPEKDSWTVN DIQKLVGKLN WASQIYPGIK
     VKQLCKLLRG AKALT
//