ID A0A345FVV0_9ENTE Unreviewed; 189 AA. AC A0A345FVV0; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 16-JAN-2019, entry version 3. DE RecName: Full=Signal peptidase I {ECO:0000256|RuleBase:RU003993}; DE EC=3.4.21.89 {ECO:0000256|RuleBase:RU003993}; GN Name=lepB {ECO:0000313|EMBL:AXG39882.1}; GN ORFNames=EGCR1_14205 {ECO:0000313|EMBL:AXG39882.1}; OS Enterococcus gilvus. OG Plasmid pcr1a {ECO:0000313|Proteomes:UP000253883}. OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae; OC Enterococcus. OX NCBI_TaxID=160453 {ECO:0000313|EMBL:AXG39882.1, ECO:0000313|Proteomes:UP000253883}; RN [1] {ECO:0000313|EMBL:AXG39882.1, ECO:0000313|Proteomes:UP000253883} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=CR1 {ECO:0000313|EMBL:AXG39882.1, RC ECO:0000313|Proteomes:UP000253883}; RC PLASMID=pcr1a {ECO:0000313|Proteomes:UP000253883}; RA Ohki S., Hagi T., Nakano K., Shiroma A., Tamotsu H., Shimoji M., RA Shinzato M., Ashimine N., Minami M., Nakanishi T., Teruya K., RA Satou K., Moriya N., Kobayashi M., Nomura M., Suzuki C., Hirano T.; RT "Complete Genome Sequence of Carotenoid-producing Enterococcus gilvus RT CR1 Isolated from Raw Cow's Milk."; RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases. CC -!- CATALYTIC ACTIVITY: CC Reaction=Cleavage of hydrophobic, N-terminal signal or leader CC sequences from secreted and periplasmic proteins.; EC=3.4.21.89; CC Evidence={ECO:0000256|RuleBase:RU003993}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU362042}; CC Single-pass type II membrane protein CC {ECO:0000256|RuleBase:RU362042}. CC -!- SIMILARITY: Belongs to the peptidase S26 family. CC {ECO:0000256|RuleBase:RU362042}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP030933; AXG39882.1; -; Genomic_DNA. DR Proteomes; UP000253883; Plasmid pcr1a. DR GO; GO:0016021; C:integral component of membrane; IEA:InterPro. DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro. DR InterPro; IPR036286; LexA/Signal_pep-like_sf. DR InterPro; IPR000223; Pept_S26A_signal_pept_1. DR InterPro; IPR019758; Pept_S26A_signal_pept_1_CS. DR InterPro; IPR019757; Pept_S26A_signal_pept_1_Lys-AS. DR InterPro; IPR019756; Pept_S26A_signal_pept_1_Ser-AS. DR InterPro; IPR015927; Peptidase_S24_S26A/B/C. DR Pfam; PF00717; Peptidase_S24; 1. DR PRINTS; PR00727; LEADERPTASE. DR SUPFAM; SSF51306; SSF51306; 1. DR TIGRFAMs; TIGR02227; sigpep_I_bact; 1. DR PROSITE; PS00501; SPASE_I_1; 1. DR PROSITE; PS00760; SPASE_I_2; 1. DR PROSITE; PS00761; SPASE_I_3; 1. PE 3: Inferred from homology; KW Complete proteome {ECO:0000313|Proteomes:UP000253883}; KW Hydrolase {ECO:0000256|RuleBase:RU003993, KW ECO:0000313|EMBL:AXG39882.1}; KW Membrane {ECO:0000256|RuleBase:RU362042}; KW Plasmid {ECO:0000313|EMBL:AXG39882.1}; KW Protease {ECO:0000256|RuleBase:RU003993}; KW Transmembrane {ECO:0000256|RuleBase:RU362042}; KW Transmembrane helix {ECO:0000256|RuleBase:RU362042}. FT TRANSMEM 7 26 Helical. {ECO:0000256|RuleBase:RU362042}. FT DOMAIN 30 95 Peptidase_S24. {ECO:0000259|Pfam: FT PF00717}. SQ SEQUENCE 189 AA; 21823 MW; BE8EE94FD4CE2E10 CRC64; MNNKIKEWLP VVIIIVLIFL ARMFVFSPVK VEGHSMDPTL HDSQRLITSK ISTLKRQDII TTKEPDNQNI YVVKRIIGVP GDRVAMKNNV LTINGEEVPE PYLDDFKEKF KKDKLAEEYS YSTAFQEQAA NATSFTNDFD VTVPNNQYFV LGDNRLISKD SRIFGFVDKS LIQGKVVLRF WPLDKFKLF //