ID A0A343ULZ4_9GOBI Unreviewed; 460 AA. AC A0A343ULZ4; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 05-DEC-2018, entry version 2. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4 {ECO:0000256|RuleBase:RU003297}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU003297}; GN Name=ND4 {ECO:0000313|EMBL:AVE15017.1}; OS Eucyclogobius newberryi (tidewater goby). OG Mitochondrion {ECO:0000313|EMBL:AVE15017.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; OC Gobiaria; Gobiiformes; Gobioidei; Gobiidae; Gobionellinae; OC Eucyclogobius. OX NCBI_TaxID=166745 {ECO:0000313|EMBL:AVE15017.1}; RN [1] {ECO:0000313|EMBL:AVE15017.1} RP NUCLEOTIDE SEQUENCE. RA Gong L., Lu Z.-M., Guo B.-Y., Ye Y.-Y., Liu L.-Q.; RT "Characterization of the complete mitochondrial genome of the RT tidewater goby, Eucyclogobius newberryi (gobiiformes; gobiidae; RT gobionellinae) and its phylogenetic implications."; RL Conserv Genet Resour 0:0-0(2018). CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory CC chain NADH dehydrogenase (Complex I) that is believed to belong to CC the minimal assembly required for catalysis. Complex I functions CC in the transfer of electrons from NADH to the respiratory chain. CC The immediate electron acceptor for the enzyme is believed to be CC ubiquinone. {ECO:0000256|RuleBase:RU003297}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 CC H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, CC ChEBI:CHEBI:57945, Rhea:RHEA-COMP:9565, Rhea:RHEA-COMP:9566; CC EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU003297}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|RuleBase:RU003297}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU003297}. CC -!- SIMILARITY: Belongs to the complex I subunit 4 family. CC {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707377}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MF038886; AVE15017.1; -; Genomic_DNA. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR InterPro; IPR000260; NADH4_N. DR InterPro; IPR010227; NADH_Q_OxRdtase_chainM/4. DR InterPro; IPR003918; NADH_UbQ_OxRdtase. DR InterPro; IPR001750; ND/Mrp_mem. DR PANTHER; PTHR43507; PTHR43507; 1. DR Pfam; PF01059; Oxidored_q5_N; 1. DR Pfam; PF00361; Proton_antipo_M; 1. DR PRINTS; PR01437; NUOXDRDTASE4. DR TIGRFAMs; TIGR01972; NDH_I_M; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU003297}; KW Membrane {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707373}; KW Mitochondrion {ECO:0000256|RuleBase:RU003297, KW ECO:0000313|EMBL:AVE15017.1}; KW NAD {ECO:0000256|RuleBase:RU003297, ECO:0000256|SAAS:SAAS00707374}; KW Respiratory chain {ECO:0000256|RuleBase:RU003297}; KW Transmembrane {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707385}; KW Transmembrane helix {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00707361}; KW Transport {ECO:0000256|RuleBase:RU003297}; KW Ubiquinone {ECO:0000256|RuleBase:RU003297, KW ECO:0000256|SAAS:SAAS00699082}. FT TRANSMEM 23 42 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 62 81 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 93 111 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 117 137 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 149 168 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 226 245 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 260 279 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 286 304 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 310 331 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 352 370 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 390 415 Helical. {ECO:0000256|RuleBase:RU003297}. FT TRANSMEM 436 458 Helical. {ECO:0000256|RuleBase:RU003297}. FT DOMAIN 1 110 Oxidored_q5_N. {ECO:0000259|Pfam: FT PF01059}. FT DOMAIN 113 404 Proton_antipo_M. {ECO:0000259|Pfam: FT PF00361}. SQ SEQUENCE 460 AA; 50909 MW; FA4C98A3790E422F CRC64; MLKILIPTMM LIPTTWLAPS KHIWPSALAH SLIIAIFSLL WLSSPGETGW WLLSNLMALD PLSTPLLVLT CWLLPLMILA SQNHTSAEPV NRQRMYLMLL TSLQIFLIIA FSATEVLLFY VMFEATLIPT LILITRWGSQ GERLNAGTYF LFYTLAASLP LLVALLILQK TTGSLSLLPL PYAAAFPLIS VADKLWWAGC LLAFLVKMPL YGMHLWLPKA HVEAPIAGSM ILAAVLLKLG GYGMMRMMVV LEPLTKELSY PFIILALWGV IMTGSVCLRQ TDLKSLIAYS SVGHMGLVAG GILIQTPWGF TGALILMIAH GLTSSALLCL ANTNYERTHT RTMMLARGMQ MLLPLMTSWW FIATLANLAL PPLPNLMGEL MIITSLFNWS WMTIVLTGGG TLITAGYSLY MFLMTQRGPV PQHILALNPS HTREHLLLAL HLLPLLLLIL NPTLVWGWTA //