ID   A0A343RQL8_MAMPR        Unreviewed;       318 AA.
AC   A0A343RQL8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   11-DEC-2019, entry version 6.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|RuleBase:RU000473};
DE            EC=7.1.1.2 {ECO:0000256|RuleBase:RU000473};
GN   Name=ND1 {ECO:0000313|EMBL:AUF72756.1};
OS   Mammuthus primigenius (Siberian woolly mammoth).
OG   Mitochondrion {ECO:0000313|EMBL:AUF72756.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Mammuthus.
OX   NCBI_TaxID=37349 {ECO:0000313|EMBL:AUF72756.1};
RN   [1] {ECO:0000313|EMBL:AUF72756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JK2769 {ECO:0000313|EMBL:AUF72756.1};
RA   Fellows Yates J.A., Drucker D.G., Reiter E., Heumos S., Welker F.,
RA   Munzel S.C., Wojtal P., Laznickova-Galetova M., Conard N.J., Herbig A.,
RA   Bocherens H., Krause J.;
RT   "Central European Woolly Mammoth Population Dynamics: Insights from Late
RT   Pleistocene Mitochondrial Genomes.";
RL   Sci. Rep. 7:17715-17715(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000256|RuleBase:RU000473};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU000471}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family.
CC       {ECO:0000256|RuleBase:RU000471}.
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DR   EMBL; MF579938; AUF72756.1; -; Genomic_DNA.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:AUF72756.1};
KW   NAD {ECO:0000256|RuleBase:RU000471};
KW   Transmembrane {ECO:0000256|RuleBase:RU000471, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubiquinone {ECO:0000256|RuleBase:RU000473}.
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        101..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        140..160
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        172..191
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        220..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        254..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..314
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   318 AA;  35718 MW;  693816461EBAB823 CRC64;
     MFLINVLTVT LPILLAVAFL TLVERKALGY MQLRKGPNVV GPYGLLQPIA DAIKLFTKEP
     VXPQTSSKFL FTVAPILALT LALTVWAPLP MPYPLINLNL SLLFILAMSS LMVYSILWSG
     WASNSKYALM GALRAVAQTI SYEVSMTTII LSMVLMNGSF TLTAFATTQE HLWLIFPMWP
     LMMMWFTSTL AETNRAPFDL TEGESELVSG FNVEYSAGPF ALFFMAEYAN IIMMNALTVI
     LFMGTSCNPQ MPEISTINFV VKTIILTICF LWVRASYPRF RYDQLMYLLW KNFLPLTLAL
     CMWHISILIS LACIPPQA
//