ID   A0A343RQL8_MAMPR        Unreviewed;       318 AA.
AC   A0A343RQL8;
DT   07-NOV-2018, integrated into UniProtKB/TrEMBL.
DT   07-NOV-2018, sequence version 1.
DT   16-JAN-2019, entry version 3.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|RuleBase:RU000473};
DE            EC=7.1.1.2 {ECO:0000256|RuleBase:RU000473};
GN   Name=ND1 {ECO:0000313|EMBL:AUF72756.1};
OS   Mammuthus primigenius (Siberian woolly mammoth).
OG   Mitochondrion {ECO:0000313|EMBL:AUF72756.1}.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Mammuthus.
OX   NCBI_TaxID=37349 {ECO:0000313|EMBL:AUF72756.1};
RN   [1] {ECO:0000313|EMBL:AUF72756.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=JK2769 {ECO:0000313|EMBL:AUF72756.1};
RA   Fellows Yates J.A., Drucker D.G., Reiter E., Heumos S., Welker F.,
RA   Munzel S.C., Wojtal P., Laznickova-Galetova M., Conard N.J.,
RA   Herbig A., Bocherens H., Krause J.;
RT   "Central European Woolly Mammoth Population Dynamics: Insights from
RT   Late Pleistocene Mitochondrial Genomes.";
RL   Sci. Rep. 7:17715-17715(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4
CC         H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=7.1.1.2; Evidence={ECO:0000256|RuleBase:RU000473};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU000471}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 1 family.
CC       {ECO:0000256|RuleBase:RU000471}.
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DR   EMBL; MF579938; AUF72756.1; -; Genomic_DNA.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation-reduction process; IEA:InterPro.
DR   HAMAP; MF_01350; NDH1_NuoH; 1.
DR   InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR   InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR   PANTHER; PTHR11432; PTHR11432; 1.
DR   Pfam; PF00146; NADHdh; 1.
DR   PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR   PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Mitochondrion {ECO:0000256|RuleBase:RU000473,
KW   ECO:0000313|EMBL:AUF72756.1}; NAD {ECO:0000256|RuleBase:RU000471};
KW   Transmembrane {ECO:0000256|RuleBase:RU000471,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubiquinone {ECO:0000256|RuleBase:RU000473}.
FT   TRANSMEM     69     89       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    101    120       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    140    160       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    172    191       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    220    242       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    254    273       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    293    314       Helical. {ECO:0000256|SAM:Phobius}.
SQ   SEQUENCE   318 AA;  35718 MW;  693816461EBAB823 CRC64;
     MFLINVLTVT LPILLAVAFL TLVERKALGY MQLRKGPNVV GPYGLLQPIA DAIKLFTKEP
     VXPQTSSKFL FTVAPILALT LALTVWAPLP MPYPLINLNL SLLFILAMSS LMVYSILWSG
     WASNSKYALM GALRAVAQTI SYEVSMTTII LSMVLMNGSF TLTAFATTQE HLWLIFPMWP
     LMMMWFTSTL AETNRAPFDL TEGESELVSG FNVEYSAGPF ALFFMAEYAN IIMMNALTVI
     LFMGTSCNPQ MPEISTINFV VKTIILTICF LWVRASYPRF RYDQLMYLLW KNFLPLTLAL
     CMWHISILIS LACIPPQA
//