ID A0A343EVL1_RUSUN Unreviewed; 98 AA. AC A0A343EVL1; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 07-APR-2021, entry version 9. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L {ECO:0000256|RuleBase:RU004419}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU004419}; GN Name=ND4L {ECO:0000313|EMBL:ASM81625.1}; OS Rusa unicolor hainana. OG Mitochondrion {ECO:0000313|EMBL:ASM81625.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae; OC Cervinae; Rusa. OX NCBI_TaxID=660297 {ECO:0000313|EMBL:ASM81625.1}; RN [1] {ECO:0000313|EMBL:ASM81625.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ASM81625.1}; RA Liu H., Xing X., Yang F., Dong Y., Fu H., Wang W.; RT "Molecular phylogeny of Rusa unicolor based on the complete sequence of RT mitochondrial genome."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|RuleBase:RU004419}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU004419}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC membrane {ECO:0000256|ARBA:ARBA00004225, CC ECO:0000256|RuleBase:RU004419}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004225, ECO:0000256|RuleBase:RU004419}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000256|ARBA:ARBA00010519, ECO:0000256|RuleBase:RU004419}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY946815; ASM81625.1; -; Genomic_DNA. DR SMR; A0A343EVL1; -. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-UniRule. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:UniProtKB-UniRule. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434; PTHR11434; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|RuleBase:RU004419}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004419}; KW Mitochondrion {ECO:0000256|RuleBase:RU004419, ECO:0000313|EMBL:ASM81625.1}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU004419}; KW Respiratory chain {ECO:0000256|RuleBase:RU004419}; KW Translocase {ECO:0000256|RuleBase:RU004419}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU004419}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU004419}; Transport {ECO:0000256|RuleBase:RU004419}; KW Ubiquinone {ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 6..22 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 29..49 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 55..79 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" SQ SEQUENCE 98 AA; 10748 MW; 5F3D8B5DEA6D7D88 CRC64; MSLVYMNIMT AFMVALAGLL MYRSHLMSSL LCLEGMMLSL FVMASLTILN SHFTLASMMP IILLVFAACE AALGLSLLVK VSNTYGTDYV QNLNLLQC //