ID A0A343EVL1_RUSUN Unreviewed; 98 AA. AC A0A343EVL1; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 27-NOV-2024, entry version 22. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 4L {ECO:0000256|ARBA:ARBA00016612, ECO:0000256|RuleBase:RU004419}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU004419}; GN Name=ND4L {ECO:0000313|EMBL:ASM81625.1}; OS Rusa unicolor hainana. OG Mitochondrion {ECO:0000313|EMBL:ASM81625.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Cervidae; OC Cervinae; Rusa. OX NCBI_TaxID=660297 {ECO:0000313|EMBL:ASM81625.1}; RN [1] {ECO:0000313|EMBL:ASM81625.1} RP NUCLEOTIDE SEQUENCE. RC TISSUE=Blood {ECO:0000313|EMBL:ASM81625.1}; RA Liu H., Xing X., Yang F., Dong Y., Fu H., Wang W.; RT "Molecular phylogeny of Rusa unicolor based on the complete sequence of RT mitochondrial genome."; RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Part of the enzyme membrane arm which is embedded in the CC lipid bilayer and involved in proton translocation. CC {ECO:0000256|ARBA:ARBA00043911}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 CC H(+)(out); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00043775}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29092; CC Evidence={ECO:0000256|ARBA:ARBA00043775}; CC -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex CC I) which is composed of 45 different subunits. CC {ECO:0000256|ARBA:ARBA00024376}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU004419}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004448, CC ECO:0000256|RuleBase:RU004419}. CC -!- SIMILARITY: Belongs to the complex I subunit 4L family. CC {ECO:0000256|ARBA:ARBA00010519, ECO:0000256|RuleBase:RU004419}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KY946815; ASM81625.1; -; Genomic_DNA. DR AlphaFoldDB; A0A343EVL1; -. DR SMR; A0A343EVL1; -. DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell. DR GO; GO:0030964; C:NADH dehydrogenase complex; IEA:TreeGrafter. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0042773; P:ATP synthesis coupled electron transport; IEA:UniProtKB-UniRule. DR FunFam; 1.10.287.3510:FF:000002; NADH-ubiquinone oxidoreductase chain 4L; 1. DR Gene3D; 1.10.287.3510; -; 1. DR InterPro; IPR001133; NADH_UbQ_OxRdtase_chain4L/K. DR InterPro; IPR039428; NUOK/Mnh_C1-like. DR PANTHER; PTHR11434:SF0; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 4L; 1. DR PANTHER; PTHR11434; NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT ND4L; 1. DR Pfam; PF00420; Oxidored_q2; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|ARBA:ARBA00022982, KW ECO:0000256|RuleBase:RU004419}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004419}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|RuleBase:RU004419}; KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792, KW ECO:0000256|RuleBase:RU004419}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU004419}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660, KW ECO:0000256|RuleBase:RU004419}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU004419}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU004419}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU004419}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU004419}; KW Ubiquinone {ECO:0000256|ARBA:ARBA00023075, ECO:0000256|RuleBase:RU004419}. FT TRANSMEM 6..22 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 29..49 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" FT TRANSMEM 55..79 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004419" SQ SEQUENCE 98 AA; 10748 MW; 5F3D8B5DEA6D7D88 CRC64; MSLVYMNIMT AFMVALAGLL MYRSHLMSSL LCLEGMMLSL FVMASLTILN SHFTLASMMP IILLVFAACE AALGLSLLVK VSNTYGTDYV QNLNLLQC //