ID A0A343AXG7_HEMSA Unreviewed; 311 AA. AC A0A343AXG7; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 02-OCT-2024, entry version 15. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1 {ECO:0000256|ARBA:ARBA00021009, ECO:0000256|RuleBase:RU000473}; DE EC=7.1.1.2 {ECO:0000256|RuleBase:RU000473}; GN Name=nad1 {ECO:0000313|EMBL:APT69309.1}; OS Hemigrapsus sanguineus (Asian shore crab). OG Mitochondrion {ECO:0000313|EMBL:APT69309.1}. OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Multicrustacea; OC Malacostraca; Eumalacostraca; Eucarida; Decapoda; Pleocyemata; Brachyura; OC Eubrachyura; Grapsoidea; Varunidae; Hemigrapsus. OX NCBI_TaxID=40176 {ECO:0000313|EMBL:APT69309.1}; RN [1] {ECO:0000313|EMBL:APT69309.1} RP NUCLEOTIDE SEQUENCE. RA Liu Q.-N., Tang B.-P.; RT "The complete mitochondrial genome of Hemigrapsus sanguineus."; RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) that is believed to belong to the CC minimal assembly required for catalysis. Complex I functions in the CC transfer of electrons from NADH to the respiratory chain. The immediate CC electron acceptor for the enzyme is believed to be ubiquinone. CC {ECO:0000256|ARBA:ARBA00003257}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) + CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|RuleBase:RU000473}; CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion CC inner membrane {ECO:0000256|RuleBase:RU000471}; Multi-pass membrane CC protein {ECO:0000256|RuleBase:RU000471}. CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. CC {ECO:0000256|ARBA:ARBA00010535, ECO:0000256|RuleBase:RU000471}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KX456205; APT69309.1; -; Genomic_DNA. DR AlphaFoldDB; A0A343AXG7; -. DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:TreeGrafter. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC. DR GO; GO:0003954; F:NADH dehydrogenase activity; IEA:TreeGrafter. DR GO; GO:0009060; P:aerobic respiration; IEA:TreeGrafter. DR HAMAP; MF_01350; NDH1_NuoH; 1. DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO. DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS. DR InterPro; IPR000731; SSD. DR PANTHER; PTHR11432; NADH DEHYDROGENASE SUBUNIT 1; 1. DR PANTHER; PTHR11432:SF3; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 1; 1. DR Pfam; PF00146; NADHdh; 1. DR PROSITE; PS00667; COMPLEX1_ND1_1; 1. DR PROSITE; PS00668; COMPLEX1_ND1_2; 1. DR PROSITE; PS50156; SSD; 1. PE 3: Inferred from homology; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Mitochondrion {ECO:0000256|RuleBase:RU000473, ECO:0000313|EMBL:APT69309.1}; KW NAD {ECO:0000256|RuleBase:RU000471}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU000471}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Ubiquinone {ECO:0000256|RuleBase:RU000473}. FT TRANSMEM 6..30 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 71..91 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 103..124 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 144..166 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 173..190 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 216..245 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 252..272 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 292..310 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 1..113 FT /note="SSD" FT /evidence="ECO:0000259|PROSITE:PS50156" SQ SEQUENCE 311 AA; 35563 MW; C7B229C19E875CA2 CRC64; MIVEVINFLV LMVCVLIGVA FVTLLERKIL GYIQIRKGPN KVGYMGILQP FSDAVKLFTK EQIVPTMSNF LVYYLCPVFS LFVSLVVWCV LPYETGLMSF NLSILFFLCC LSVGVYSTMV AGWSSNCKYS LLGSLRAVAQ TISYEVSLAL ILLSFVMLIG GFSLELFNKY QNYFWFVMIS FPLSMVWFSS CLTETNRTPF DFAEGESDLV SGFNTYYGAG GFALIFMAEY PSILFMIVLF TIFFLGSKPF KLMFYFKPIM EAFAFVWVRG TLPRLRYDKL MYLAWKSSLP VSINYLIFFV SLKMFCFCLL S //