ID A0A342CGA6_9TELE Unreviewed; 171 AA. AC A0A342CGA6; DT 07-NOV-2018, integrated into UniProtKB/TrEMBL. DT 07-NOV-2018, sequence version 1. DT 27-NOV-2024, entry version 17. DE RecName: Full=NADH-ubiquinone oxidoreductase chain 6 {ECO:0000256|ARBA:ARBA00021095, ECO:0000256|RuleBase:RU004430}; DE EC=7.1.1.2 {ECO:0000256|ARBA:ARBA00012944, ECO:0000256|RuleBase:RU004430}; GN Name=ND6 {ECO:0000313|EMBL:AHZ58284.1}; OS Pseudobagrus medianalis. OG Mitochondrion {ECO:0000313|EMBL:AHZ58284.1}. OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; OC Bagridae; Pseudobagrus. OX NCBI_TaxID=1498490 {ECO:0000313|EMBL:AHZ58284.1}; RN [1] {ECO:0000313|EMBL:AHZ58284.1} RP NUCLEOTIDE SEQUENCE. RA Liang H.W.; RT "Mitochondrial genome sequence of the Pseudobagrus medianalis."; RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain CC NADH dehydrogenase (Complex I) which catalyzes electron transfer from CC NADH through the respiratory chain, using ubiquinone as an electron CC acceptor. Essential for the catalytic activity and assembly of complex CC I. {ECO:0000256|RuleBase:RU004430}. CC -!- CATALYTIC ACTIVITY: CC Reaction=a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 CC H(+)(out); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA- CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976, CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2; CC Evidence={ECO:0000256|ARBA:ARBA00000766, CC ECO:0000256|RuleBase:RU004430}; CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane CC {ECO:0000256|ARBA:ARBA00004225, ECO:0000256|RuleBase:RU004430}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004225, CC ECO:0000256|RuleBase:RU004430}. CC -!- SIMILARITY: Belongs to the complex I subunit 6 family. CC {ECO:0000256|ARBA:ARBA00005698, ECO:0000256|RuleBase:RU004430}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; KJ507136; AHZ58284.1; -; Genomic_DNA. DR AlphaFoldDB; A0A342CGA6; -. DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell. DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-UniRule. DR InterPro; IPR050269; ComplexI_Subunit6. DR InterPro; IPR001457; NADH_UbQ/plastoQ_OxRdtase_su6. DR PANTHER; PTHR11435; NADH UBIQUINONE OXIDOREDUCTASE SUBUNIT ND6; 1. DR PANTHER; PTHR11435:SF1; NADH-UBIQUINONE OXIDOREDUCTASE CHAIN 6; 1. DR Pfam; PF00499; Oxidored_q3; 1. PE 3: Inferred from homology; KW Electron transport {ECO:0000256|ARBA:ARBA00022982, KW ECO:0000256|RuleBase:RU004430}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU004430}; KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128, KW ECO:0000256|RuleBase:RU004430}; KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU004430}; KW Respiratory chain {ECO:0000256|ARBA:ARBA00022660, KW ECO:0000256|RuleBase:RU004430}; Signal {ECO:0000256|SAM:SignalP}; KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU004430}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU004430}; KW Transmembrane helix {ECO:0000256|RuleBase:RU004430}; KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU004430}; KW Ubiquinone {ECO:0000256|RuleBase:RU004430}. FT SIGNAL 1..21 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 22..171 FT /note="NADH-ubiquinone oxidoreductase chain 6" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5016765112" FT TRANSMEM 51..75 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 87..106 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" FT TRANSMEM 133..157 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU004430" SQ SEQUENCE 171 AA; 18140 MW; 5C9556809AAEFBEB CRC64; MMYFLDLLLL SLVVGLVGVA SNPAPYFAAL GLAMAAGVGC VVLVGHGGSL IGLMLFLIYL GGMLVVFAYS AALASEPFPE TWGAGSVKTY VLMYLFVVGV AGWWFWSGYG GWVVVDEFKE FFMVRGDVGG VSLMYSVGGG MLVVCAWVLL LCLFVVLELT RGLSRGALRA V //