ID A0A341CMX6_NEOAA Unreviewed; 374 AA. AC A0A341CMX6; DT 10-OCT-2018, integrated into UniProtKB/TrEMBL. DT 10-OCT-2018, sequence version 1. DT 05-FEB-2025, entry version 27. DE RecName: Full=glycerophosphocholine cholinephosphodiesterase {ECO:0000256|ARBA:ARBA00012318}; DE EC=3.1.4.38 {ECO:0000256|ARBA:ARBA00012318}; DE AltName: Full=Choline-specific glycerophosphodiester phosphodiesterase {ECO:0000256|ARBA:ARBA00032556}; DE AltName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 {ECO:0000256|ARBA:ARBA00031167}; GN Name=ENPP6 {ECO:0000313|RefSeq:XP_024615745.1}; OS Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) OS (Neophocaena phocaenoides subsp. asiaeorientalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; OC Phocoenidae; Neophocaena. OX NCBI_TaxID=1706337 {ECO:0000313|Proteomes:UP000252040, ECO:0000313|RefSeq:XP_024615745.1}; RN [1] {ECO:0000313|RefSeq:XP_024615745.1} RP IDENTIFICATION. RC TISSUE=Meat {ECO:0000313|RefSeq:XP_024615745.1}; RG RefSeq; RL Submitted (OCT-2024) to UniProtKB. CC -!- FUNCTION: Choline-specific glycerophosphodiesterase that hydrolyzes CC glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and CC contributes to supplying choline to the cells. Has a preference for LPC CC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty CC acids. In vitro, hydrolyzes only choline-containing lysophospholipids, CC such as sphingosylphosphorylcholine (SPC), platelet-activating factor CC (PAF) and lysoPAF, but not other lysophospholipids. CC {ECO:0000256|ARBA:ARBA00046203}. CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine CC + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + CC phosphocholine + H(+); Xref=Rhea:RHEA:41003, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:34071, ChEBI:CHEBI:74344, CC ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00049320}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41004; CC Evidence={ECO:0000256|ARBA:ARBA00049320}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = CC 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + phosphocholine + H(+); CC Xref=Rhea:RHEA:41115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:28733, ChEBI:CHEBI:75561, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00049092}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41116; CC Evidence={ECO:0000256|ARBA:ARBA00049092}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z- CC octadecenoyl)-sn-glycerol + phosphocholine + H(+); CC Xref=Rhea:RHEA:41091, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:28610, ChEBI:CHEBI:75757, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00047322}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41092; CC Evidence={ECO:0000256|ARBA:ARBA00047322}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl- CC sn-glycerol + phosphocholine + H(+); Xref=Rhea:RHEA:41127, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74966, CC ChEBI:CHEBI:75529, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00047290}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41128; CC Evidence={ECO:0000256|ARBA:ARBA00047290}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- CC hexadecanoyl-sn-glycerol + phosphocholine + H(+); CC Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00048209}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; CC Evidence={ECO:0000256|ARBA:ARBA00048209}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1- CC tetradecanoyl-sn-glycerol + phosphocholine + H(+); CC Xref=Rhea:RHEA:40999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:64489, ChEBI:CHEBI:75536, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00047779}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41000; CC Evidence={ECO:0000256|ARBA:ARBA00047779}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1-O-alkyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl- CC sn-glycerol + phosphocholine + H(+); Xref=Rhea:RHEA:36083, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, CC ChEBI:CHEBI:30909, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00047494}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36084; CC Evidence={ECO:0000256|ARBA:ARBA00047494}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- CC glycerol + phosphocholine + H(+); Xref=Rhea:RHEA:44720, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168, CC ChEBI:CHEBI:64683, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00047600}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44721; CC Evidence={ECO:0000256|ARBA:ARBA00047600}; CC -!- CATALYTIC ACTIVITY: CC Reaction=glycero-2-phosphocholine + H2O = phosphocholine + glycerol + CC H(+); Xref=Rhea:RHEA:61684, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:17754, ChEBI:CHEBI:144950, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00047482}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61685; CC Evidence={ECO:0000256|ARBA:ARBA00047482}; CC -!- CATALYTIC ACTIVITY: CC Reaction=sn-glycerol 3-phosphocholine + H2O = phosphocholine + glycerol CC + H(+); Xref=Rhea:RHEA:19545, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:16870, ChEBI:CHEBI:17754, ChEBI:CHEBI:295975; CC EC=3.1.4.38; Evidence={ECO:0000256|ARBA:ARBA00048703}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19546; CC Evidence={ECO:0000256|ARBA:ARBA00048703}; CC -!- CATALYTIC ACTIVITY: CC Reaction=sphing-4-enine-phosphocholine + H2O = sphing-4-enine + CC phosphocholine + H(+); Xref=Rhea:RHEA:41095, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57756, ChEBI:CHEBI:58906, CC ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00048234}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41096; CC Evidence={ECO:0000256|ARBA:ARBA00048234}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SUBUNIT: Homodimer; disulfide-linked. Homotetramer. CC {ECO:0000256|ARBA:ARBA00046706}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609}; CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. CC -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase CC family. {ECO:0000256|ARBA:ARBA00010594}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_024615745.1; XM_024759977.1. DR AlphaFoldDB; A0A341CMX6; -. DR Proteomes; UP000252040; Unplaced. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW. DR GO; GO:0047390; F:glycerophosphocholine cholinephosphodiesterase activity; IEA:UniProtKB-EC. DR GO; GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IEA:TreeGrafter. DR GO; GO:0019695; P:choline metabolic process; IEA:TreeGrafter. DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. DR CDD; cd16018; Enpp; 1. DR FunFam; 3.30.1360.180:FF:000001; Ectonucleotide pyrophosphatase/phosphodiesterase family member 6; 1. DR FunFam; 3.40.720.10:FF:000029; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; 1. DR Gene3D; 3.30.1360.180; -; 1. DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1. DR InterPro; IPR017850; Alkaline_phosphatase_core_sf. DR InterPro; IPR002591; Phosphodiest/P_Trfase. DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1. DR PANTHER; PTHR10151:SF66; GLYCEROPHOSPHOCHOLINE CHOLINEPHOSPHODIESTERASE ENPP6; 1. DR Pfam; PF01663; Phosphodiest; 1. DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1. PE 3: Inferred from homology; KW Cell membrane {ECO:0000256|ARBA:ARBA00022475}; KW Glycoprotein {ECO:0000256|ARBA:ARBA00022622}; KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622}; KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000252040}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..374 FT /note="glycerophosphocholine cholinephosphodiesterase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5016402130" SQ SEQUENCE 374 AA; 43398 MW; 65DA56A09B368F33 CRC64; MAEKLGALLL ALVLSLAQPA PARRKLLVFL LDGFRSDYIS DEVLESLPGF REIVSRGVKA DYLTPDFPSL SYPNYYSLMT GRHCEVHQMI GNYMWDPATN KSFDIGVNRD SLMPLWWNGS EPLWITLTKA KRKVYMYYWP GCEVEILGVR PTYCLEYKNV PTDINFANAV SDALDFFKSG QADLVAIYYE RIDVEGHHYG PSSPQRKEAL RAVDTVLKYM TTWIQERELQ DDLNVIIFSD HGMTDIFWMD KVIELDKYIS LHDLQQVKDR GPVVSLWPVP GKHSEIYNKL RTVEHMTVYK KEAIPSRFYY KKGKFVSPLT LVADEGWFIT ENRETLPFWM NSTDKRQGWQ RGWHGYDNEL RDMRGIFLAF GPAI //