ID A0A341CMX6_NEOAA Unreviewed; 374 AA. AC A0A341CMX6; DT 10-OCT-2018, integrated into UniProtKB/TrEMBL. DT 10-OCT-2018, sequence version 1. DT 29-MAY-2024, entry version 23. DE RecName: Full=glycerophosphocholine cholinephosphodiesterase {ECO:0000256|ARBA:ARBA00012318}; DE EC=3.1.4.38 {ECO:0000256|ARBA:ARBA00012318}; DE AltName: Full=Choline-specific glycerophosphodiester phosphodiesterase {ECO:0000256|ARBA:ARBA00032556}; DE AltName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 {ECO:0000256|ARBA:ARBA00031167}; GN Name=ENPP6 {ECO:0000313|RefSeq:XP_024615745.1}; OS Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise) OS (Neophocaena phocaenoides subsp. asiaeorientalis). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; OC Phocoenidae; Neophocaena. OX NCBI_TaxID=1706337 {ECO:0000313|Proteomes:UP000252040, ECO:0000313|RefSeq:XP_024615745.1}; RN [1] {ECO:0000313|RefSeq:XP_024615745.1} RP IDENTIFICATION. RC TISSUE=Meat {ECO:0000313|RefSeq:XP_024615745.1}; RG RefSeq; RL Submitted (FEB-2024) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine CC + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) + CC phosphocholine; Xref=Rhea:RHEA:41003, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:34071, ChEBI:CHEBI:74344, CC ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00000776}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41004; CC Evidence={ECO:0000256|ARBA:ARBA00000776}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O = CC 1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine; CC Xref=Rhea:RHEA:41115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:28733, ChEBI:CHEBI:75561, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00000637}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41116; CC Evidence={ECO:0000256|ARBA:ARBA00000637}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z- CC octadecenoyl)-sn-glycerol + H(+) + phosphocholine; CC Xref=Rhea:RHEA:41091, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:28610, ChEBI:CHEBI:75757, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00024461}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41092; CC Evidence={ECO:0000256|ARBA:ARBA00024461}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn- CC glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:36083, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850, CC ChEBI:CHEBI:30909, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00000101}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36084; CC Evidence={ECO:0000256|ARBA:ARBA00000101}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl- CC sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41127, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74966, CC ChEBI:CHEBI:75529, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00001317}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41128; CC Evidence={ECO:0000256|ARBA:ARBA00001317}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1- CC hexadecanoyl-sn-glycerol + H(+) + phosphocholine; CC Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00000008}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120; CC Evidence={ECO:0000256|ARBA:ARBA00000008}; CC -!- CATALYTIC ACTIVITY: CC Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1- CC tetradecanoyl-sn-glycerol + H(+) + phosphocholine; CC Xref=Rhea:RHEA:40999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:64489, ChEBI:CHEBI:75536, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00000256}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41000; CC Evidence={ECO:0000256|ARBA:ARBA00000256}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) + CC phosphocholine; Xref=Rhea:RHEA:19545, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:17754, CC ChEBI:CHEBI:295975; EC=3.1.4.38; CC Evidence={ECO:0000256|ARBA:ARBA00001458}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19546; CC Evidence={ECO:0000256|ARBA:ARBA00001458}; CC -!- CATALYTIC ACTIVITY: CC Reaction=H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine + CC sphing-4-enine; Xref=Rhea:RHEA:41095, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57756, ChEBI:CHEBI:58906, CC ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00000756}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41096; CC Evidence={ECO:0000256|ARBA:ARBA00000756}; CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn- CC glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:44720, CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168, CC ChEBI:CHEBI:64683, ChEBI:CHEBI:295975; CC Evidence={ECO:0000256|ARBA:ARBA00000769}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44721; CC Evidence={ECO:0000256|ARBA:ARBA00000769}; CC -!- CATALYTIC ACTIVITY: CC Reaction=glycero-2-phosphocholine + H2O = glycerol + H(+) + CC phosphocholine; Xref=Rhea:RHEA:61684, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:144950, CC ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00000554}; CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61685; CC Evidence={ECO:0000256|ARBA:ARBA00000554}; CC -!- COFACTOR: CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105; CC Evidence={ECO:0000256|ARBA:ARBA00001947}; CC -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase CC family. {ECO:0000256|ARBA:ARBA00010594}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_024615745.1; XM_024759977.1. DR AlphaFoldDB; A0A341CMX6; -. DR Proteomes; UP000252040; Unplaced. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0047390; F:glycerophosphocholine cholinephosphodiesterase activity; IEA:UniProtKB-EC. DR GO; GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IEA:TreeGrafter. DR GO; GO:0019695; P:choline metabolic process; IEA:TreeGrafter. DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. DR CDD; cd16018; Enpp; 1. DR Gene3D; 3.30.1360.180; -; 1. DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1. DR InterPro; IPR017850; Alkaline_phosphatase_core_sf. DR InterPro; IPR002591; Phosphodiest/P_Trfase. DR PANTHER; PTHR10151; ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE; 1. DR PANTHER; PTHR10151:SF66; GLYCEROPHOSPHOCHOLINE CHOLINEPHOSPHODIESTERASE ENPP6; 1. DR Pfam; PF01663; Phosphodiest; 1. DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1. PE 3: Inferred from homology; KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963}; KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098}; KW Membrane {ECO:0000256|ARBA:ARBA00023136}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Reference proteome {ECO:0000313|Proteomes:UP000252040}; KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}; KW Zinc {ECO:0000256|ARBA:ARBA00022833}. FT SIGNAL 1..22 FT /evidence="ECO:0000256|SAM:SignalP" FT CHAIN 23..374 FT /note="glycerophosphocholine cholinephosphodiesterase" FT /evidence="ECO:0000256|SAM:SignalP" FT /id="PRO_5016402130" SQ SEQUENCE 374 AA; 43398 MW; 65DA56A09B368F33 CRC64; MAEKLGALLL ALVLSLAQPA PARRKLLVFL LDGFRSDYIS DEVLESLPGF REIVSRGVKA DYLTPDFPSL SYPNYYSLMT GRHCEVHQMI GNYMWDPATN KSFDIGVNRD SLMPLWWNGS EPLWITLTKA KRKVYMYYWP GCEVEILGVR PTYCLEYKNV PTDINFANAV SDALDFFKSG QADLVAIYYE RIDVEGHHYG PSSPQRKEAL RAVDTVLKYM TTWIQERELQ DDLNVIIFSD HGMTDIFWMD KVIELDKYIS LHDLQQVKDR GPVVSLWPVP GKHSEIYNKL RTVEHMTVYK KEAIPSRFYY KKGKFVSPLT LVADEGWFIT ENRETLPFWM NSTDKRQGWQ RGWHGYDNEL RDMRGIFLAF GPAI //