ID   A0A341CMX6_NEOAA        Unreviewed;       374 AA.
AC   A0A341CMX6;
DT   10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 1.
DT   03-AUG-2022, entry version 15.
DE   RecName: Full=Glycerophosphocholine cholinephosphodiesterase {ECO:0000256|ARBA:ARBA00012318};
DE            EC=3.1.4.38 {ECO:0000256|ARBA:ARBA00012318};
DE   AltName: Full=Choline-specific glycerophosphodiester phosphodiesterase {ECO:0000256|ARBA:ARBA00032556};
DE   AltName: Full=Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 {ECO:0000256|ARBA:ARBA00031167};
GN   Name=ENPP6 {ECO:0000313|RefSeq:XP_024615745.1};
OS   Neophocaena asiaeorientalis asiaeorientalis (Yangtze finless porpoise)
OS   (Neophocaena phocaenoides subsp. asiaeorientalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Phocoenidae; Neophocaena.
OX   NCBI_TaxID=1706337 {ECO:0000313|RefSeq:XP_024615745.1};
RN   [1] {ECO:0000313|RefSeq:XP_024615745.1}
RP   IDENTIFICATION.
RC   TISSUE=Meat {ECO:0000313|RefSeq:XP_024615745.1};
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine
CC         + H2O = 1-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycerol + H(+) +
CC         phosphocholine; Xref=Rhea:RHEA:41003, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:34071, ChEBI:CHEBI:74344,
CC         ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00000776};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41004;
CC         Evidence={ECO:0000256|ARBA:ARBA00000776};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(9Z,12Z)-octadecadienoyl-sn-glycero-3-phosphocholine + H2O =
CC         1-(9Z,12Z-octadecadienoyl)-sn-glycerol + H(+) + phosphocholine;
CC         Xref=Rhea:RHEA:41115, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:28733, ChEBI:CHEBI:75561, ChEBI:CHEBI:295975;
CC         Evidence={ECO:0000256|ARBA:ARBA00000637};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41116;
CC         Evidence={ECO:0000256|ARBA:ARBA00000637};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine + H2O = 1-(9Z-
CC         octadecenoyl)-sn-glycerol + H(+) + phosphocholine;
CC         Xref=Rhea:RHEA:41091, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:28610, ChEBI:CHEBI:75757, ChEBI:CHEBI:295975;
CC         Evidence={ECO:0000256|ARBA:ARBA00024461};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41092;
CC         Evidence={ECO:0000256|ARBA:ARBA00024461};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-O-alkyl-sn-glycero-3-phosphocholine + H2O = 1-O-alkyl-sn-
CC         glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:36083,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15850,
CC         ChEBI:CHEBI:30909, ChEBI:CHEBI:295975;
CC         Evidence={ECO:0000256|ARBA:ARBA00000101};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:36084;
CC         Evidence={ECO:0000256|ARBA:ARBA00000101};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-dodecanoyl-sn-glycero-3-phosphocholine + H2O = 1-dodecanoyl-
CC         sn-glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:41127,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:74966,
CC         ChEBI:CHEBI:75529, ChEBI:CHEBI:295975;
CC         Evidence={ECO:0000256|ARBA:ARBA00001317};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41128;
CC         Evidence={ECO:0000256|ARBA:ARBA00001317};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-hexadecanoyl-sn-glycero-3-phosphocholine + H2O = 1-
CC         hexadecanoyl-sn-glycerol + H(+) + phosphocholine;
CC         Xref=Rhea:RHEA:41119, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:72998, ChEBI:CHEBI:75542, ChEBI:CHEBI:295975;
CC         Evidence={ECO:0000256|ARBA:ARBA00000008};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41120;
CC         Evidence={ECO:0000256|ARBA:ARBA00000008};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-tetradecanoyl-sn-glycero-3-phosphocholine + H2O = 1-
CC         tetradecanoyl-sn-glycerol + H(+) + phosphocholine;
CC         Xref=Rhea:RHEA:40999, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:64489, ChEBI:CHEBI:75536, ChEBI:CHEBI:295975;
CC         Evidence={ECO:0000256|ARBA:ARBA00000256};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41000;
CC         Evidence={ECO:0000256|ARBA:ARBA00000256};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + sn-glycerol 3-phosphocholine = glycerol + H(+) +
CC         phosphocholine; Xref=Rhea:RHEA:19545, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16870, ChEBI:CHEBI:17754,
CC         ChEBI:CHEBI:295975; EC=3.1.4.38;
CC         Evidence={ECO:0000256|ARBA:ARBA00001458};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19546;
CC         Evidence={ECO:0000256|ARBA:ARBA00001458};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + sphing-4-enine-phosphocholine = H(+) + phosphocholine +
CC         sphing-4-enine; Xref=Rhea:RHEA:41095, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57756, ChEBI:CHEBI:58906,
CC         ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00000756};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:41096;
CC         Evidence={ECO:0000256|ARBA:ARBA00000756};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1-acyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-
CC         glycerol + H(+) + phosphocholine; Xref=Rhea:RHEA:44720,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58168,
CC         ChEBI:CHEBI:64683, ChEBI:CHEBI:295975;
CC         Evidence={ECO:0000256|ARBA:ARBA00000769};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44721;
CC         Evidence={ECO:0000256|ARBA:ARBA00000769};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=glycero-2-phosphocholine + H2O = glycerol + H(+) +
CC         phosphocholine; Xref=Rhea:RHEA:61684, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17754, ChEBI:CHEBI:144950,
CC         ChEBI:CHEBI:295975; Evidence={ECO:0000256|ARBA:ARBA00000554};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:61685;
CC         Evidence={ECO:0000256|ARBA:ARBA00000554};
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the nucleotide pyrophosphatase/phosphodiesterase
CC       family. {ECO:0000256|ARBA:ARBA00010594}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_024615745.1; XM_024759977.1.
DR   GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR   GO; GO:0047390; F:glycerophosphocholine cholinephosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.720.10; -; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR029889; ENPP6.
DR   InterPro; IPR002591; Phosphodiest/P_Trfase.
DR   PANTHER; PTHR10151:SF66; PTHR10151:SF66; 1.
DR   Pfam; PF01663; Phosphodiest; 1.
DR   SUPFAM; SSF53649; SSF53649; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Signal {ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           23..374
FT                   /note="Glycerophosphocholine cholinephosphodiesterase"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5016402130"
SQ   SEQUENCE   374 AA;  43398 MW;  65DA56A09B368F33 CRC64;
     MAEKLGALLL ALVLSLAQPA PARRKLLVFL LDGFRSDYIS DEVLESLPGF REIVSRGVKA
     DYLTPDFPSL SYPNYYSLMT GRHCEVHQMI GNYMWDPATN KSFDIGVNRD SLMPLWWNGS
     EPLWITLTKA KRKVYMYYWP GCEVEILGVR PTYCLEYKNV PTDINFANAV SDALDFFKSG
     QADLVAIYYE RIDVEGHHYG PSSPQRKEAL RAVDTVLKYM TTWIQERELQ DDLNVIIFSD
     HGMTDIFWMD KVIELDKYIS LHDLQQVKDR GPVVSLWPVP GKHSEIYNKL RTVEHMTVYK
     KEAIPSRFYY KKGKFVSPLT LVADEGWFIT ENRETLPFWM NSTDKRQGWQ RGWHGYDNEL
     RDMRGIFLAF GPAI
//