ID A0A330IZX0_CHAVI Unreviewed; 293 AA. AC A0A330IZX0; DT 10-OCT-2018, integrated into UniProtKB/TrEMBL. DT 10-OCT-2018, sequence version 1. DT 29-MAY-2024, entry version 12. DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235}; DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235}; DE Flags: Fragment; GN Name=BCHE {ECO:0000313|EMBL:SMQ11532.1}; OS Chaetophractus villosus (South American armadillo). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Xenarthra; Cingulata; Chlamyphoridae; Chaetophractus. OX NCBI_TaxID=29080 {ECO:0000313|EMBL:SMQ11532.1}; RN [1] {ECO:0000313|EMBL:SMQ11532.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=TNP390 {ECO:0000313|EMBL:SMQ11532.1}; RA Song R., Chenine A.L., Ruprecht R.M.; RL Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Esterase with broad substrate specificity. Contributes to the CC inactivation of the neurotransmitter acetylcholine. Can degrade CC neurotoxic organophosphate esters. {ECO:0000256|ARBA:ARBA00037444}. CC -!- CATALYTIC ACTIVITY: CC Reaction=an acylcholine + H2O = a carboxylate + choline + H(+); CC Xref=Rhea:RHEA:21964, ChEBI:CHEBI:15354, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:35287; EC=3.1.1.8; CC Evidence={ECO:0000256|ARBA:ARBA00036543}; CC -!- SUBUNIT: Homotetramer; disulfide-linked. Dimer of dimers. CC {ECO:0000256|ARBA:ARBA00038819}. CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family. CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LT852612; SMQ11532.1; -; Genomic_DNA. DR AlphaFoldDB; A0A330IZX0; -. DR GO; GO:0005615; C:extracellular space; IEA:TreeGrafter. DR GO; GO:0005886; C:plasma membrane; IEA:TreeGrafter. DR GO; GO:0003990; F:acetylcholinesterase activity; IEA:TreeGrafter. DR GO; GO:0006581; P:acetylcholine catabolic process; IEA:TreeGrafter. DR GO; GO:0019695; P:choline metabolic process; IEA:TreeGrafter. DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1. DR InterPro; IPR029058; AB_hydrolase. DR InterPro; IPR002018; CarbesteraseB. DR InterPro; IPR019826; Carboxylesterase_B_AS. DR InterPro; IPR000997; Cholinesterase. DR PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1. DR PANTHER; PTHR43918:SF5; CHOLINESTERASE; 1. DR Pfam; PF00135; COesterase; 1. DR PRINTS; PR00878; CHOLNESTRASE. DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1. DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1. PE 3: Inferred from homology; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235}; KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553}; KW Serine esterase {ECO:0000256|ARBA:ARBA00022487}. FT DOMAIN 1..293 FT /note="Carboxylesterase type B" FT /evidence="ECO:0000259|Pfam:PF00135" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:SMQ11532.1" FT NON_TER 293 FT /evidence="ECO:0000313|EMBL:SMQ11532.1" SQ SEQUENCE 293 AA; 32617 MW; 5645135BB56F76E1 CRC64; TVMVWIYGGG FQTGTSSLPV YDGRFLARVE RVIVVSMNYR VGALGFLALP GHLEAPGNMG LFDQQLALQW VQKNIAAFGG NPKSVTLFGE SAGSVSVNLH LFSPKSHPFF TRVILQSGSS NAPWAVISLH EAKNRTLTLA KFLGCSRENE TEIIKCLRNK DPQEILLNEV LVVPYDSLLS VNFGPIVDGD FLTDMPDTLL QLRQYKKTQI LVGVNKDEGS AFLVYGAPGF SKDNSSIITR KEFQEGLKIF FPRLSDLGKE SILFHYTDWL DDQRPEIYRE AMDDVVGDYN IIC //