ID A0A2Z5CVS8_PHYAT Unreviewed; 170 AA. AC A0A2Z5CVS8; DT 10-OCT-2018, integrated into UniProtKB/TrEMBL. DT 10-OCT-2018, sequence version 1. DT 07-NOV-2018, entry version 2. DE RecName: Full=Cytochrome c oxidase subunit 1 {ECO:0000256|RuleBase:RU000369}; DE EC=1.9.3.1 {ECO:0000256|RuleBase:RU000369}; DE Flags: Fragment; GN Name=COI {ECO:0000313|EMBL:AXB26808.1}; OS Physella acuta (Acute bladder snail) (Physa acuta). OG Mitochondrion {ECO:0000313|EMBL:AXB26808.1}. OC Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea; OC Physidae; Physella. OX NCBI_TaxID=109671 {ECO:0000313|EMBL:AXB26808.1}; RN [1] {ECO:0000313|EMBL:AXB26808.1} RP NUCLEOTIDE SEQUENCE. RC STRAIN=S41 {ECO:0000313|EMBL:AXB26808.1}; RX PubMed=29969987; RA Ebbs E.T., Loker E.S., Brant S.V.; RT "Phylogeography and genetics of the globally invasive snail Physa RT acuta Draparnaud 1805, and its potential to serve as an intermediate RT host to larval digenetic trematodes."; RL BMC Evol. Biol. 18:103-103(2018). CC -!- FUNCTION: Cytochrome c oxidase is the component of the respiratory CC chain that catalyzes the reduction of oxygen to water. Subunits 1- CC 3 form the functional core of the enzyme complex. CO I is the CC catalytic subunit of the enzyme. Electrons originating in CC cytochrome c are transferred via the copper A center of subunit 2 CC and heme A of subunit 1 to the bimetallic center formed by heme A3 CC and copper B. {ECO:0000256|RuleBase:RU000369}. CC -!- CATALYTIC ACTIVITY: 4 ferrocytochrome c + O(2) + 4 H(+) = 4 CC ferricytochrome c + 2 H(2)O. {ECO:0000256|RuleBase:RU000369}. CC -!- PATHWAY: Energy metabolism; oxidative phosphorylation. CC {ECO:0000256|RuleBase:RU000369}. CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane CC {ECO:0000256|RuleBase:RU000369}; Multi-pass membrane protein CC {ECO:0000256|RuleBase:RU000369}. CC -!- SIMILARITY: Belongs to the heme-copper respiratory oxidase family. CC {ECO:0000256|RuleBase:RU000369}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MF694461; AXB26808.1; -; Genomic_DNA. DR UniPathway; UPA00705; -. DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW. DR Gene3D; 1.20.210.10; -; 1. DR InterPro; IPR023616; Cyt_c_oxase-like_su1_dom. DR InterPro; IPR036927; Cyt_c_oxase-like_su1_sf. DR InterPro; IPR000883; Cyt_C_Oxase_1. DR PANTHER; PTHR10422; PTHR10422; 1. DR Pfam; PF00115; COX1; 1. DR PRINTS; PR01165; CYCOXIDASEI. DR SUPFAM; SSF81442; SSF81442; 1. DR PROSITE; PS50855; COX1; 1. PE 3: Inferred from homology; KW Copper {ECO:0000256|RuleBase:RU000369}; KW Electron transport {ECO:0000256|RuleBase:RU000369}; KW Heme {ECO:0000256|RuleBase:RU000369}; KW Iron {ECO:0000256|RuleBase:RU000369}; KW Membrane {ECO:0000256|RuleBase:RU000369, ECO:0000256|SAM:Phobius}; KW Metal-binding {ECO:0000256|RuleBase:RU000369}; KW Mitochondrion {ECO:0000256|RuleBase:RU000369, KW ECO:0000313|EMBL:AXB26808.1}; KW Mitochondrion inner membrane {ECO:0000256|RuleBase:RU000369}; KW Oxidoreductase {ECO:0000256|RuleBase:RU000369}; KW Respiratory chain {ECO:0000256|RuleBase:RU000369}; KW Transmembrane {ECO:0000256|RuleBase:RU000369, KW ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|SAM:Phobius}; KW Transport {ECO:0000256|RuleBase:RU000369}. FT TRANSMEM 29 50 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 71 93 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 113 138 Helical. {ECO:0000256|SAM:Phobius}. FT TRANSMEM 150 169 Helical. {ECO:0000256|SAM:Phobius}. FT DOMAIN 1 170 COX1. {ECO:0000259|PROSITE:PS50855}. FT NON_TER 1 1 {ECO:0000313|EMBL:AXB26808.1}. FT NON_TER 170 170 {ECO:0000313|EMBL:AXB26808.1}. SQ SEQUENCE 170 AA; 18611 MW; 70DE88505EBB8F0F CRC64; LSLLIRLELG TSLVLLDEHF YNVIVTKHAF VMIFFMVMPM MIGGFGNWMV PMLIGAPDMS FPRMNNMSFW LLPPSFILLL CSSMVEGGVG TGWTVYPPLS GPVAHSGSSV DLAIFSLHLA GLSSILGAIN FITTIFNMRS PGITLERMSL FVWSVLITAF LLLLSLPVLA //