ID A0A2Z4JMN1_9BURK Unreviewed; 639 AA. AC A0A2Z4JMN1; DT 10-OCT-2018, integrated into UniProtKB/TrEMBL. DT 10-OCT-2018, sequence version 1. DT 05-DEC-2018, entry version 3. DE RecName: Full=UvrABC system protein C {ECO:0000256|HAMAP-Rule:MF_00203, ECO:0000256|SAAS:SAAS00383990}; DE Short=Protein UvrC {ECO:0000256|HAMAP-Rule:MF_00203}; DE AltName: Full=Excinuclease ABC subunit C {ECO:0000256|HAMAP-Rule:MF_00203}; GN Name=uvrC {ECO:0000256|HAMAP-Rule:MF_00203}; GN ORFNames=DPM18_06320 {ECO:0000313|EMBL:AWW46450.1}; OS Polynucleobacter asymbioticus. OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales; OC Burkholderiaceae; Polynucleobacter. OX NCBI_TaxID=576611 {ECO:0000313|EMBL:AWW46450.1, ECO:0000313|Proteomes:UP000249527}; RN [1] {ECO:0000313|EMBL:AWW46450.1, ECO:0000313|Proteomes:UP000249527} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=UB-Kaiv-W7 {ECO:0000313|EMBL:AWW46450.1, RC ECO:0000313|Proteomes:UP000249527}; RA Hahn M.W.; RT "Description of a new Polynucleobacter species."; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and CC processing of DNA lesions. UvrC both incises the 5' and 3' sides CC of the lesion. The N-terminal half is responsible for the 3' CC incision and the C-terminal half is responsible for the 5' CC incision. {ECO:0000256|HAMAP-Rule:MF_00203, CC ECO:0000256|SAAS:SAAS00384019}. CC -!- SUBUNIT: Interacts with UvrB in an incision complex. CC {ECO:0000256|HAMAP-Rule:MF_00203, ECO:0000256|SAAS:SAAS00088179}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203, CC ECO:0000256|SAAS:SAAS00383975}. CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000256|HAMAP- CC Rule:MF_00203, ECO:0000256|SAAS:SAAS00571147}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP030088; AWW46450.1; -; Genomic_DNA. DR Proteomes; UP000249527; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule. DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule. DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule. DR Gene3D; 3.30.420.340; -; 1. DR Gene3D; 3.40.1440.10; -; 1. DR HAMAP; MF_00203; UvrC; 1. DR InterPro; IPR000305; GIY-YIG_endonuc. DR InterPro; IPR035901; GIY-YIG_endonuc_sf. DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif. DR InterPro; IPR010994; RuvA_2-like. DR InterPro; IPR001943; UVR_dom. DR InterPro; IPR036876; UVR_dom_sf. DR InterPro; IPR004791; UvrC. DR InterPro; IPR001162; UvrC_homol_region. DR InterPro; IPR038476; UvrC_homol_region_sf. DR Pfam; PF01541; GIY-YIG; 1. DR Pfam; PF02151; UVR; 1. DR Pfam; PF08459; UvrC_HhH_N; 1. DR SMART; SM00465; GIYc; 1. DR SMART; SM00278; HhH1; 2. DR SUPFAM; SSF46600; SSF46600; 1. DR SUPFAM; SSF47781; SSF47781; 1. DR SUPFAM; SSF82771; SSF82771; 1. DR TIGRFAMs; TIGR00194; uvrC; 1. DR PROSITE; PS50164; GIY_YIG; 1. DR PROSITE; PS50151; UVR; 1. DR PROSITE; PS50165; UVRC; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Complete proteome {ECO:0000313|Proteomes:UP000249527}; KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00203, KW ECO:0000256|SAAS:SAAS00511279}; KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00203, KW ECO:0000256|SAAS:SAAS00125846}; KW DNA excision {ECO:0000256|HAMAP-Rule:MF_00203, KW ECO:0000256|SAAS:SAAS00088146}; KW DNA repair {ECO:0000256|HAMAP-Rule:MF_00203, KW ECO:0000256|SAAS:SAAS00125847}; KW Excision nuclease {ECO:0000256|HAMAP-Rule:MF_00203, KW ECO:0000256|SAAS:SAAS00511323}; KW SOS response {ECO:0000256|HAMAP-Rule:MF_00203, KW ECO:0000256|SAAS:SAAS01013796}. FT DOMAIN 18 96 GIY-YIG. {ECO:0000259|PROSITE:PS50164}. FT DOMAIN 205 240 UVR. {ECO:0000259|PROSITE:PS50151}. FT DOMAIN 258 513 UVRC. {ECO:0000259|PROSITE:PS50165}. FT COILED 58 85 {ECO:0000256|SAM:Coils}. FT COILED 208 228 {ECO:0000256|SAM:Coils}. FT COILED 405 425 {ECO:0000256|SAM:Coils}. SQ SEQUENCE 639 AA; 71595 MW; 880348EA5083DB4F CRC64; MSNSLFETLQ QDVKRLPGLP GVYRFFDEAG HILYVGKARN LKKRVSSYFQ RTQLSPRIQN MVRKIARYET TVTRTETEAL ILENNLIKEL SPPFNILFRD DKSYPYVMLT GHTFPRLASY RGKVDKRNRY FGPFPNSWAV RNSVQILQKV FRLRTCEDSV FKNRSRPCLL HQIHRCSAPC VGRLSEEQYG QDVMQATRFL EGDHSRVLSE LEKEMEAHSE AMEFEMAAVM RDRIADLSSV LQQQSMDTVA DGEGDVDIIA VAQMEGMICV NLAMVRGGRH LGDRPYFPKG LRMSSGEQAS PAEILETFIQ QHYLEDESTE GGASTTNLIP PVFILNHSLQ IAAEDGGSSE DKSVESLQSL LSIQAGKKIT FLHQPQGQRR HWLAMAEGNA KLALTKRLVE TGGQLARARA LADVLSLDLE NLEQLRIECF DISHTSGEAT QASCVVYAKN DMQSSEYRRF NIDGITPGDD YAAMRQVLQR RYANFQELPV DKLPQVILID GGKGQVEMAR QVLTEFGMDI SLIVGVAKGE GRKVGLETLI FADERKPLEL GIDSAALLLV AQIRDEAHRF AITGMRAKRA KARTVSRLEE IEGIGAKRRQ KLLARFGGLR GVAGATVEEI AGVDGISMTL AEQIYRQLH //