ID A0A2Z4GWW8_TRINI Unreviewed; 852 AA. AC A0A2Z4GWW8; DT 10-OCT-2018, integrated into UniProtKB/TrEMBL. DT 10-OCT-2018, sequence version 1. DT 14-DEC-2022, entry version 11. DE SubName: Full=K+-Cl-co-transporter {ECO:0000313|EMBL:AWW06968.1}; DE Flags: Fragment; OS Trichoplusia ni (Cabbage looper). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; OC Noctuidae; Plusiinae; Trichoplusia. OX NCBI_TaxID=7111 {ECO:0000313|EMBL:AWW06968.1}; RN [1] {ECO:0000313|EMBL:AWW06968.1} RP NUCLEOTIDE SEQUENCE. RX PubMed=29908900; RA Kolosov D., Tauqir M., Rajaruban S., Piermarini P.M., Donini A., RA O'Donnell M.J.; RT "Molecular mechanisms of bi-directional ion transport in the Malpighian RT tubules of a lepidopteran crop pest, Trichoplusia ni."; RL J. Insect Physiol. 109:55-68(2018). CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MH048896; AWW06968.1; -; mRNA. DR AlphaFoldDB; A0A2Z4GWW8; -. DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell. DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro. DR GO; GO:0071477; P:cellular hypotonic salinity response; IEA:InterPro. DR InterPro; IPR004841; AA-permease/SLC12A_dom. DR InterPro; IPR030364; KCC3. DR InterPro; IPR000076; KCL_cotranspt. DR InterPro; IPR018491; SLC12_C. DR InterPro; IPR004842; SLC12A_fam. DR PANTHER; PTHR11827:SF66; SOLUTE CARRIER FAMILY 12 MEMBER 6; 1. DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1. DR Pfam; PF00324; AA_permease; 2. DR Pfam; PF03522; SLC12; 2. DR PRINTS; PR01081; KCLTRNSPORT. DR TIGRFAMs; TIGR00930; 2a30; 1. PE 2: Evidence at transcript level; KW Chloride {ECO:0000256|ARBA:ARBA00023214}; KW Ion transport {ECO:0000256|ARBA:ARBA00023065}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius}; KW Potassium {ECO:0000256|ARBA:ARBA00022958}; KW Potassium transport {ECO:0000256|ARBA:ARBA00022538}; KW Symport {ECO:0000256|ARBA:ARBA00022847}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}. FT TRANSMEM 31..52 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 64..89 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 109..137 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 158..177 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 183..204 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 306..325 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 345..369 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 474..495 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT TRANSMEM 507..524 FT /note="Helical" FT /evidence="ECO:0000256|SAM:Phobius" FT DOMAIN 32..208 FT /note="AA_permease" FT /evidence="ECO:0000259|Pfam:PF00324" FT DOMAIN 312..589 FT /note="AA_permease" FT /evidence="ECO:0000259|Pfam:PF00324" FT DOMAIN 605..725 FT /note="SLC12" FT /evidence="ECO:0000259|Pfam:PF03522" FT DOMAIN 735..806 FT /note="SLC12" FT /evidence="ECO:0000259|Pfam:PF03522" FT NON_TER 1 FT /evidence="ECO:0000313|EMBL:AWW06968.1" FT NON_TER 852 FT /evidence="ECO:0000313|EMBL:AWW06968.1" SQ SEQUENCE 852 AA; 93843 MW; 6576C7941440288D CRC64; SLANYSNTIP TAAAGDPDAK PAPPARMGTL IGVYLPCIQN IFGVILFIRL TWVVGTAGAI QGFLIVLVCC CTTMLTAISM SAIATNGVVP AGGSYFMIGR ALGPECGGAV GMLFYTGTTL AAAMYIVGAV EIVLTYMAPW MSIFGDFTKD PEAMYNNFRV YGTGLLLIMG MVVFVGVKFV NKFATVALAC VILSITAVYV GIFVNFNGND KLQMCVLGKR LLKDININNC TKEIGAPLHQ LFCPNNTCDP YYLAHNVSIV QGIKGLKSGV FFDNLQDSFL QLGQYIAYGK EPDDIEQMER PTYNQVYADL TTTFTILIGI FFPSVTGIMA GSNRSGDLAD AQKSIPIGTI CAILTTSTVY LSCVLLFAGT VDNLLLRDKF GQSIGGKLVV ANMAWPNQWV ILIGSFLSTL GAGLQSLTGA PRLLQAIAKD EIIPFLAPFA VSSSRGEPTR ALLLTMVICQ CGILLGNVDI LAPLLSMFFL MCYGFVNLAC ALQTLLKTPN WRPRFKYYHW SLSLAGLTLC ISIMFMTSWF YALIAMGMAG LIYKYIEYRG AEKEWGDGLR GLALSAARYS LLRLEQGPPH TKNWRPQVLV LAKLNNELMP TYRKMLAFAS QLKAGKGLTV CVSVLGGDFP RRAGDASSAK QNLRKCMDEE KLKGFVDVLV SPDIAEGLSH LVQTTGLGGL KPNTVIVGWP YGWRQAERSA PRWQHFLHTV RAVAAARMAM LVPKGINFFP DSTEKVSGNI DIWWIVHDGG MLMLLPFLLK QHRTWKNCKM RIFTVAQMED NSIQMKKDLK MFLYQLRLEA EVEVVEMTDS DISAYTYERT LMMEQRNQML RELRLNKKET MGMVQAIVDH HH //