ID   A0A2Y9S1E8_PHYMC        Unreviewed;       310 AA.
AC   A0A2Y9S1E8;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   22-FEB-2023, entry version 27.
DE   SubName: Full=short stature homeobox protein isoform X1 {ECO:0000313|RefSeq:XP_023971277.1};
GN   Name=SHOX {ECO:0000313|RefSeq:XP_023971277.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_023971277.1};
RN   [1] {ECO:0000313|RefSeq:XP_023971277.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_023971277.1};
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC       ECO:0000256|RuleBase:RU000682}.
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DR   RefSeq; XP_023971277.1; XM_024115509.1.
DR   AlphaFoldDB; A0A2Y9S1E8; -.
DR   KEGG; pcad:102986455; -.
DR   OrthoDB; 2897127at2759; -.
DR   Proteomes; UP000248484; Chromosome 7.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR000047; HTH_motif.
DR   InterPro; IPR003654; OAR_dom.
DR   PANTHER; PTHR46255; SHORT STATURE HOMEOBOX; 1.
DR   PANTHER; PTHR46255:SF2; SHORT STATURE HOMEOBOX PROTEIN; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   Pfam; PF03826; OAR; 1.
DR   PRINTS; PR00031; HTHREPRESSR.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   PROSITE; PS50803; OAR; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW   ProRule:PRU00108};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000248484}.
FT   DOMAIN          115..175
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000259|PROSITE:PS50071"
FT   DOMAIN          292..305
FT                   /note="OAR"
FT                   /evidence="ECO:0000259|PROSITE:PS50803"
FT   DNA_BIND        117..176
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          100..119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   310 AA;  34167 MW;  6722846C9C34CBFD CRC64;
     MEELTAFVSK SFDQKSKDSS GGGGGGGGKK DSITYREVLE SGLARSRELG VSESNLQDIT
     EGSGHCPVHL FKDHVDNDKD KLKEFGSGRA AEGIYDCKEK REDVKSEDED GQTKLKQRRS
     RTNFTLEQLN ELERLFDETH YPDAFMREEL SQRLGLSEAR VQVWFQNRRA KCRKQENQMH
     KGVILGTASH LDACRVAPYV NMGALRMPFQ QVAQPPRSRV LTVRVPPSQV QAQLQLEGVA
     HAHPHLHPHL AAHAPYLMFP PPPFGLPIAS LAESASAAAV VAAAAKSNSK NSSIADLRLK
     ARKHAEALGL
//