ID   A0A2Y9ER32_PHYMC        Unreviewed;       264 AA.
AC   A0A2Y9ER32;
DT   12-SEP-2018, integrated into UniProtKB/TrEMBL.
DT   12-SEP-2018, sequence version 1.
DT   12-OCT-2022, entry version 18.
DE   SubName: Full=nicotinamide N-methyltransferase {ECO:0000313|RefSeq:XP_007106683.1};
GN   Name=NNMT {ECO:0000313|RefSeq:XP_007106683.1};
OS   Physeter macrocephalus (Sperm whale) (Physeter catodon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti;
OC   Physeteridae; Physeter.
OX   NCBI_TaxID=9755 {ECO:0000313|Proteomes:UP000248484, ECO:0000313|RefSeq:XP_007106683.1};
RN   [1] {ECO:0000313|RefSeq:XP_007106683.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_007106683.1};
RG   RefSeq;
RL   Submitted (APR-2022) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. NNMT/PNMT/TEMT family. {ECO:0000256|ARBA:ARBA00007996}.
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DR   RefSeq; XP_007106683.1; XM_007106621.3.
DR   STRING; 9755.ENSPCTP00005028204; -.
DR   Ensembl; ENSPCTT00005031040; ENSPCTP00005028204; ENSPCTG00005020216.
DR   GeneID; 102992107; -.
DR   KEGG; pcad:102992107; -.
DR   CTD; 4837; -.
DR   Proteomes; UP000248484; Chromosome 16.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0008112; F:nicotinamide N-methyltransferase activity; IEA:Ensembl.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006769; P:nicotinamide metabolic process; IEA:Ensembl.
DR   GO; GO:0045722; P:positive regulation of gluconeogenesis; IEA:Ensembl.
DR   GO; GO:0090312; P:positive regulation of protein deacetylation; IEA:Ensembl.
DR   GO; GO:0051569; P:regulation of histone H3-K4 methylation; IEA:Ensembl.
DR   GO; GO:0010967; P:regulation of polyamine biosynthetic process; IEA:Ensembl.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR025820; NNMT/PNMT/TEMT_CS.
DR   InterPro; IPR000940; NNMT_TEMT_trans.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR10867; PTHR10867; 1.
DR   Pfam; PF01234; NNMT_PNMT_TEMT; 1.
DR   PIRSF; PIRSF000384; PNMTase; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   PROSITE; PS01100; NNMT_PNMT_TEMT; 1.
DR   PROSITE; PS51681; SAM_MT_NNMT_PNMT_TEMT; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000248484};
KW   S-adenosyl-L-methionine {ECO:0000256|PIRSR:PIRSR000384-1}.
FT   BINDING         20
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000384-1"
FT   BINDING         25
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000384-1"
FT   BINDING         63..64
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000384-1"
FT   BINDING         69
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000384-1"
FT   BINDING         85
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000384-1"
FT   BINDING         90
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000384-1"
FT   BINDING         142..143
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000384-1"
SQ   SEQUENCE   264 AA;  29505 MW;  6E3D3C762CBA9091 CRC64;
     MESGFTSKDT YLSHFNPQAY LEKYYNFGSR HSAEKQILRH LLKNLFKIFC LDGVKGDLLI
     DIGSGPTIYQ LLSACESFKE IIATDYTDQN LQELEKWLKK EPGAFDWSPV VTYVCELEGN
     RVKGPEKEEK LRRAIKQVLK CDVTQSWPLG AVPLPPADCL LSTLCLDAAC PDLPAYRTAL
     RNLGSLLKPG GFLVLVDALN SSYYMIGEQR FSSLCLGREA VEAAVREAGY TIEQFEEISQ
     SYSSNMANNE GLFCLVGRKL STSV
//