ID A0A2X3CEJ9_KLEPN Unreviewed; 784 AA. AC A0A2X3CEJ9; DT 12-SEP-2018, integrated into UniProtKB/TrEMBL. DT 12-SEP-2018, sequence version 1. DT 13-SEP-2023, entry version 17. DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096}; GN Name=mutS_2 {ECO:0000313|EMBL:SQC15428.1}; GN Synonyms=mutS {ECO:0000256|HAMAP-Rule:MF_00096}; GN ORFNames=NCTC9128_03543 {ECO:0000313|EMBL:SQC15428.1}; OS Klebsiella pneumoniae. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella. OX NCBI_TaxID=573 {ECO:0000313|EMBL:SQC15428.1, ECO:0000313|Proteomes:UP000251088}; RN [1] {ECO:0000313|EMBL:SQC15428.1, ECO:0000313|Proteomes:UP000251088} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=NCTC9128 {ECO:0000313|EMBL:SQC15428.1, RC ECO:0000313|Proteomes:UP000251088}; RG Pathogen Informatics; RA Doyle S.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA. CC It is possible that it carries out the mismatch recognition step. This CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647, CC ECO:0000256|HAMAP-Rule:MF_00096}. CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096, CC ECO:0000256|RuleBase:RU003756}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; UAWN01000012; SQC15428.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2X3CEJ9; -. DR EnsemblBacteria; SQC15428; SQC15428; NCTC9128_03543. DR Proteomes; UP000251088; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro. DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro. DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule. DR CDD; cd03284; ABC_MutS1; 1. DR Gene3D; 1.10.1420.10; -; 2. DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1. DR Gene3D; 3.30.420.110; MutS, connector domain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR HAMAP; MF_00096; MutS; 1. DR InterPro; IPR005748; DNA_mismatch_repair_MutS. DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N. DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH. DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C. DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp. DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core. DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N. DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf. DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom. DR InterPro; IPR036678; MutS_con_dom_sf. DR InterPro; IPR045076; MutS_family. DR InterPro; IPR027417; P-loop_NTPase. DR NCBIfam; TIGR01070; mutS1; 1. DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1. DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1. DR Pfam; PF01624; MutS_I; 1. DR Pfam; PF05188; MutS_II; 1. DR Pfam; PF05192; MutS_III; 1. DR Pfam; PF05190; MutS_IV; 1. DR Pfam; PF00488; MutS_V; 1. DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2. DR SMART; SM00534; MUTSac; 1. DR SMART; SM00533; MUTSd; 1. DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1. DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1. DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00096}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP- KW Rule:MF_00096}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP- KW Rule:MF_00096}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP- KW Rule:MF_00096}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00096}. FT DOMAIN 688..704 FT /note="DNA mismatch repair proteins mutS family" FT /evidence="ECO:0000259|PROSITE:PS00486" FT BINDING 614..621 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096" SQ SEQUENCE 784 AA; 87559 MW; 022C589E4BA05F9F CRC64; MSTIDNLDAH TPMMQQYLKL KAQHPDILLF YRMGDFYELF YDDAKRASQL LDISLTKRGA SAGEPIPMAG IPHHAVENYL AKLVNQGESV AICEQIGDPA TTKGPVERKV VRIVTPGTIS DEALLQERQD NLLAAIWQDS KGFGYATLDI SSGRFRLSEP ADRETMAAEL QRTNPAELLY AEDFAESSLI EGRRGLRRRP LWEFEIDTAR QQLNLQFGTR DLVGFGVENA PRGLCAAGCL LQYVKDTQRT SLPHIRSITM ERQQDSIIMD AATRRNLEIT QNLAGGTDNT LASVLDCTVT PMGSRMLKRW LHMPVRDTAV LVERQQTIGA LQERYTELQP VLRQVGDLER ILARLALRTA RPRDLARMRH ALQQLPLLRE LLADVDSQPV QKLREKMGEF TELRELLERA VIDAPPVLVR DGGVIAPGYS EELDEWRALA DGATDYLDKL EIRERERLGL DTLKVGYNAV HGYYIQISRG QSHLAPIHYV RRQTLKNAER YIIPELKEYE DKVLTSKGKA LALEKQLYDE LFDLLLPHLA DLQTSASALA ELDVLVNLAE RAETLNYCCP TFSDKPGIRI SEGRHPVVEQ VLKEPFIANP LQLAPQRRML IITGPNMGGK STYMRQTALI ALLAYIGSYV PAQKVEIGPI DRIFTRVGAA DDLASGRSTF MVEMTETANI LHNATEHSLV LMDEIGRGTS TYDGLSLAWA CAENLANKIK ALTLFATHYF ELTQLPEKME GVANVHLDAL EHGDTIAFMH SVQDGAASKS YGLAVAALAG CRKR //