ID A0A2X0SZ21_MOUSE Unreviewed; 724 AA. AC A0A2X0SZ21; DT 12-SEP-2018, integrated into UniProtKB/TrEMBL. DT 12-SEP-2018, sequence version 1. DT 03-JUL-2019, entry version 6. DE SubName: Full=PIK3R2 {ECO:0000313|EMBL:SPT35779.1}; DE Flags: Fragment; GN Name=PIK3R2 {ECO:0000313|EMBL:SPT35779.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; OC Muroidea; Muridae; Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:SPT35779.1}; RN [1] {ECO:0000313|EMBL:SPT35779.1} RP NUCLEOTIDE SEQUENCE. RA Zhirakovskaya E.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LS482402; SPT35779.1; -; Genomic_DNA. DR GO; GO:0007165; P:signal transduction; IEA:InterPro. DR CDD; cd09930; SH2_cSH2_p85_like; 1. DR CDD; cd09942; SH2_nSH2_p85_like; 1. DR CDD; cd11909; SH3_PI3K_p85beta; 1. DR Gene3D; 1.10.555.10; -; 1. DR Gene3D; 3.30.505.10; -; 2. DR InterPro; IPR032498; PI3K_P85_iSH2. DR InterPro; IPR035586; PI3K_p85beta_SH3. DR InterPro; IPR035020; PI3kinase_P85_cSH2. DR InterPro; IPR035022; PI3kinase_P85_nSH2. DR InterPro; IPR008936; Rho_GTPase_activation_prot. DR InterPro; IPR000198; RhoGAP_dom. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR Pfam; PF16454; PI3K_P85_iSH2; 1. DR Pfam; PF00620; RhoGAP; 1. DR Pfam; PF00017; SH2; 2. DR PRINTS; PR00401; SH2DOMAIN. DR SMART; SM00324; RhoGAP; 1. DR SMART; SM00252; SH2; 2. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF48350; SSF48350; 1. DR SUPFAM; SSF50044; SSF50044; 1. DR SUPFAM; SSF55550; SSF55550; 2. DR PROSITE; PS50238; RHOGAP; 1. DR PROSITE; PS50001; SH2; 2. DR PROSITE; PS50002; SH3; 1. PE 4: Predicted; KW Coiled coil {ECO:0000256|SAM:Coils}; KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}; KW SH3 domain {ECO:0000256|PROSITE-ProRule:PRU00192, KW ECO:0000256|SAAS:SAAS01042643}. FT DOMAIN 4 80 SH3. {ECO:0000259|PROSITE:PS50002}. FT DOMAIN 112 293 Rho-GAP. {ECO:0000259|PROSITE:PS50238}. FT DOMAIN 324 419 SH2. {ECO:0000259|PROSITE:PS50001}. FT DOMAIN 616 710 SH2. {ECO:0000259|PROSITE:PS50001}. FT REGION 84 108 Disordered. {ECO:0000256|MobiDB-lite: FT A0A2X0SZ21}. FT REGION 287 319 Disordered. {ECO:0000256|MobiDB-lite: FT A0A2X0SZ21}. FT COILED 440 467 {ECO:0000256|SAM:Coils}. FT COILED 519 539 {ECO:0000256|SAM:Coils}. FT NON_TER 724 724 {ECO:0000313|EMBL:SPT35779.1}. SQ SEQUENCE 724 AA; 81478 MW; D379FB4D49AF30CE CRC64; MAGAEGFQYR AVYPFRRERP EDLELLPGDL LVVSRVALQA LGVADGGERC PHNVGWMPGF NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP LDGSSESGHI LPDLAEQFSP PDPAPPILVK LVEAIEQAEL DSECYSKPEL PATRTDWSLS DLEQWDRTAL YDAVKGFLLA LPAAVVTPEA AAEAYRALRE VAGPVGLVLE PPTLPLHQAL TLRFLLQHLG RVARRAPSPD TAVHALASAF GPLLLRIPPS GGEGDGSEPV PDFPVLLLER LVQEHVEEQD AAPPALPPKP SKAKPAPTAL ANGGSPPSLQ DAEWYWGDIS REEVNERLRD TPDGTFLVRD ASSKIQGEYT LTLRKGGNNK LIKVFHRDGH YGFSEPLTFC SVVELISHYR HESLAQYNAK LDTRLLYPVS KYQQDQVVKE DSVEAVGAQL KVYHQQYQDK SREYDQLYEE YTRTSQELQM KRTAIEAFNE TIKIFEEQGQ TQEKCSKEYL ERFRREGNEK EMQRILLNSE RLKSRIAEIH ESRTKLEQDL RAQASDNREI DKRMNSLKPD LMQLRKIRDQ YLVWLTQKGA RQRKINEWLG IKNETEDQYS LMEDEDALPH HEERTWYVGK INRTQAEEML SGKRDGTFLI RESSQRGCYA CSVVVDGDTK HCVIYRTATG FGFAEPYNLY GSLKELVLHY QHASLVQHND ALTVTLAHPV RAPGPGPPSA ARLI //