ID A0A2X0SZ21_MOUSE Unreviewed; 724 AA. AC A0A2X0SZ21; DT 12-SEP-2018, integrated into UniProtKB/TrEMBL. DT 12-SEP-2018, sequence version 1. DT 29-MAY-2024, entry version 21. DE SubName: Full=PIK3R2 {ECO:0000313|EMBL:SPT35779.1}; DE Flags: Fragment; GN Name=PIK3R2 {ECO:0000313|EMBL:SPT35779.1}; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090 {ECO:0000313|EMBL:SPT35779.1}; RN [1] {ECO:0000313|EMBL:SPT35779.1} RP NUCLEOTIDE SEQUENCE. RA Zhirakovskaya E.; RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases. CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family. CC {ECO:0000256|ARBA:ARBA00009442}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; LS482402; SPT35779.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2X0SZ21; -. DR ChiTaRS; Pik3r2; mouse. DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:TreeGrafter. DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:TreeGrafter. DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:TreeGrafter. DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:TreeGrafter. DR CDD; cd12926; iSH2_PIK3R2; 1. DR CDD; cd09930; SH2_cSH2_p85_like; 1. DR CDD; cd09942; SH2_nSH2_p85_like; 1. DR CDD; cd11909; SH3_PI3K_p85beta; 1. DR Gene3D; 1.10.287.1490; -; 1. DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1. DR Gene3D; 3.30.505.10; SH2 domain; 2. DR Gene3D; 2.30.30.40; SH3 Domains; 1. DR InterPro; IPR032498; PI3K_P85_iSH2. DR InterPro; IPR035586; PI3K_p85beta_SH3. DR InterPro; IPR035020; PI3kinase_P85_cSH2. DR InterPro; IPR035022; PI3kinase_P85_nSH2. DR InterPro; IPR008936; Rho_GTPase_activation_prot. DR InterPro; IPR000198; RhoGAP_dom. DR InterPro; IPR000980; SH2. DR InterPro; IPR036860; SH2_dom_sf. DR InterPro; IPR036028; SH3-like_dom_sf. DR InterPro; IPR001452; SH3_domain. DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1. DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1. DR Pfam; PF16454; PI3K_P85_iSH2; 1. DR Pfam; PF00620; RhoGAP; 1. DR Pfam; PF00017; SH2; 2. DR PRINTS; PR00678; PI3KINASEP85. DR PRINTS; PR00401; SH2DOMAIN. DR SMART; SM00324; RhoGAP; 1. DR SMART; SM00252; SH2; 2. DR SMART; SM00326; SH3; 1. DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1. DR SUPFAM; SSF55550; SH2 domain; 2. DR SUPFAM; SSF50044; SH3-domain; 1. DR PROSITE; PS50238; RHOGAP; 1. DR PROSITE; PS50001; SH2; 2. DR PROSITE; PS50002; SH3; 1. PE 3: Inferred from homology; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Repeat {ECO:0000256|ARBA:ARBA00022737}; KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE- KW ProRule:PRU00191}; KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE- KW ProRule:PRU00192}; Stress response {ECO:0000256|ARBA:ARBA00023016}. FT DOMAIN 4..80 FT /note="SH3" FT /evidence="ECO:0000259|PROSITE:PS50002" FT DOMAIN 112..293 FT /note="Rho-GAP" FT /evidence="ECO:0000259|PROSITE:PS50238" FT DOMAIN 324..419 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT DOMAIN 616..710 FT /note="SH2" FT /evidence="ECO:0000259|PROSITE:PS50001" FT REGION 84..108 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 287..319 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COILED 440..467 FT /evidence="ECO:0000256|SAM:Coils" FT NON_TER 724 FT /evidence="ECO:0000313|EMBL:SPT35779.1" SQ SEQUENCE 724 AA; 81478 MW; D379FB4D49AF30CE CRC64; MAGAEGFQYR AVYPFRRERP EDLELLPGDL LVVSRVALQA LGVADGGERC PHNVGWMPGF NERTRQRGDF PGTYVEFLGP VALARPGPRP RGPRPLPARP LDGSSESGHI LPDLAEQFSP PDPAPPILVK LVEAIEQAEL DSECYSKPEL PATRTDWSLS DLEQWDRTAL YDAVKGFLLA LPAAVVTPEA AAEAYRALRE VAGPVGLVLE PPTLPLHQAL TLRFLLQHLG RVARRAPSPD TAVHALASAF GPLLLRIPPS GGEGDGSEPV PDFPVLLLER LVQEHVEEQD AAPPALPPKP SKAKPAPTAL ANGGSPPSLQ DAEWYWGDIS REEVNERLRD TPDGTFLVRD ASSKIQGEYT LTLRKGGNNK LIKVFHRDGH YGFSEPLTFC SVVELISHYR HESLAQYNAK LDTRLLYPVS KYQQDQVVKE DSVEAVGAQL KVYHQQYQDK SREYDQLYEE YTRTSQELQM KRTAIEAFNE TIKIFEEQGQ TQEKCSKEYL ERFRREGNEK EMQRILLNSE RLKSRIAEIH ESRTKLEQDL RAQASDNREI DKRMNSLKPD LMQLRKIRDQ YLVWLTQKGA RQRKINEWLG IKNETEDQYS LMEDEDALPH HEERTWYVGK INRTQAEEML SGKRDGTFLI RESSQRGCYA CSVVVDGDTK HCVIYRTATG FGFAEPYNLY GSLKELVLHY QHASLVQHND ALTVTLAHPV RAPGPGPPSA ARLI //