ID A0A2V0N4U8_9MYCO Unreviewed; 540 AA. AC A0A2V0N4U8; DT 12-SEP-2018, integrated into UniProtKB/TrEMBL. DT 12-SEP-2018, sequence version 1. DT 29-SEP-2021, entry version 12. DE RecName: Full=60 kDa chaperonin {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}; DE AltName: Full=GroEL protein {ECO:0000256|HAMAP-Rule:MF_00600}; DE AltName: Full=Protein Cpn60 {ECO:0000256|HAMAP-Rule:MF_00600}; GN Name=groL2 {ECO:0000313|EMBL:GBE65377.1}; GN Synonyms=groEL {ECO:0000256|HAMAP-Rule:MF_00600}, groL GN {ECO:0000256|HAMAP-Rule:MF_00600}; GN ORFNames=MFM001_18390 {ECO:0000313|EMBL:GBE65377.1}; OS Mycobacterium sp. MFM001. OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; OC Mycobacterium; unclassified Mycobacterium. OX NCBI_TaxID=2049453 {ECO:0000313|EMBL:GBE65377.1, ECO:0000313|Proteomes:UP000256682}; RN [1] {ECO:0000313|EMBL:GBE65377.1, ECO:0000313|Proteomes:UP000256682} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=MFM001 {ECO:0000313|EMBL:GBE65377.1, RC ECO:0000313|Proteomes:UP000256682}; RX PubMed=29885807; DOI=10.1016/j.vetmic.2018.05.010; RA Kayanuma H., Ogihara K., Yoshida S., Yamamoto K., Wada T., Yamamoto T., RA Tsuyuki Y., Madarame H.; RT "Disseminated nontuberculous mycobacterial disease in a cat caused by RT Mycobacterium sp. strain MFM001."; RL Vet. Microbiol. 220:90-96(2018). CC -!- FUNCTION: Prevents misfolding and promotes the refolding and proper CC assembly of unfolded polypeptides generated under stress conditions. CC {ECO:0000256|HAMAP-Rule:MF_00600, ECO:0000256|RuleBase:RU000419}. CC -!- SUBUNIT: Oligomer of 14 subunits composed of two stacked rings of 7 CC subunits. {ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000419}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00600}. CC -!- SIMILARITY: Belongs to the chaperonin (HSP60) family. CC {ECO:0000256|ARBA:ARBA00006607, ECO:0000256|HAMAP-Rule:MF_00600, CC ECO:0000256|RuleBase:RU000418}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:GBE65377.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BFAB01000004; GBE65377.1; -; Genomic_DNA. DR EnsemblBacteria; GBE65377; GBE65377; MFM001_18390. DR Proteomes; UP000256682; Unassembled WGS sequence. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0051082; F:unfolded protein binding; IEA:UniProtKB-UniRule. DR GO; GO:0042026; P:protein refolding; IEA:UniProtKB-UniRule. DR CDD; cd03344; GroEL; 1. DR Gene3D; 1.10.560.10; -; 1. DR Gene3D; 3.30.260.10; -; 1. DR Gene3D; 3.50.7.10; -; 1. DR HAMAP; MF_00600; CH60; 1. DR InterPro; IPR018370; Chaperonin_Cpn60_CS. DR InterPro; IPR001844; Chaprnin_Cpn60. DR InterPro; IPR002423; Cpn60/TCP-1. DR InterPro; IPR027409; GroEL-like_apical_dom_sf. DR InterPro; IPR027413; GROEL-like_equatorial_sf. DR InterPro; IPR027410; TCP-1-like_intermed_sf. DR Pfam; PF00118; Cpn60_TCP1; 1. DR PRINTS; PR00298; CHAPERONIN60. DR SUPFAM; SSF48592; SSF48592; 1. DR SUPFAM; SSF52029; SSF52029; 1. DR SUPFAM; SSF54849; SSF54849; 1. DR TIGRFAMs; TIGR02348; GroEL; 1. DR PROSITE; PS00296; CHAPERONINS_CPN60; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00600}; KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_00600}; KW Coiled coil {ECO:0000256|SAM:Coils}; KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_00600}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00600}. FT COILED 344..364 FT /evidence="ECO:0000256|SAM:Coils" FT COILED 384..407 FT /evidence="ECO:0000256|SAM:Coils" SQ SEQUENCE 540 AA; 56716 MW; E3227B3335D9858E CRC64; MAKTIAYDEE ARRGLERGLN SLADAVKVTL GPKGRNVVLE KKWGAPTITN DGVSIAKEIE LEDPYEKIGA ELVKEVAKKT DDVAGDGTTT ATVLAQALVK EGLRNVAAGA NPLGLKRGIE KAVEKVTETL LKGAKEVETK EQIAATAAIS AGDQSIGDLI AEAMDKVGNE GVITVEESNT FGLQLELTEG MRFDKGYISG YFVTDAERQE AVLEEPYILL VSSKVSTVKD LLPLLEKVIQ AGKPLLIIAE DVEGEALSTL VVNKIRGTFK SVAVKAPGFG DRRKAMLQDM AILTGGQVIS EEVGLTLENA DLSLLGKARK VVVTKDETTI VEGAGDTDAI AGRVAQIRQE IENSDSDYDR EKLQERLAKL AGGVAVIKAG AATEVELKER KHRIEDAVRN AKAAVEEGIV AGGGVTLLQA APTLDELKLS GDEATGANIV KVALEAPLKQ IAFNSGLEPG VVAEKVRNSP AGTGLNAATG EYEDLLKAGV ADPVKVTRSA LQNAASIAGL FLTTEAVVAD KPEKEKAAMP GGGDMGGMDF //