ID   A0A2U3ZIU5_ODORO        Unreviewed;       310 AA.
AC   A0A2U3ZIU5;
DT   18-JUL-2018, integrated into UniProtKB/TrEMBL.
DT   18-JUL-2018, sequence version 1.
DT   11-DEC-2019, entry version 8.
DE   RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113};
GN   Name=INSIG1 {ECO:0000313|RefSeq:XP_012418902.1};
OS   Odobenus rosmarus divergens (Pacific walrus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Odobenidae; Odobenus.
OX   NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_012418902.1};
RN   [1] {ECO:0000313|RefSeq:XP_012418902.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (MAY-2018) to UniProtKB.
CC   -!- FUNCTION: Mediates feedback control of cholesterol synthesis.
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|RuleBase:RU241113}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU241113}.
CC   -!- SIMILARITY: Belongs to the INSIG family.
CC       {ECO:0000256|RuleBase:RU241113}.
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DR   RefSeq; XP_012418902.1; XM_012563448.1.
DR   GeneID; 101373824; -.
DR   KEGG; oro:101373824; -.
DR   CTD; 3638; -.
DR   Proteomes; UP000245340; Genome assembly.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR009904; INSIG-1.
DR   InterPro; IPR025929; INSIG_fam.
DR   PANTHER; PTHR15301; PTHR15301; 1.
DR   PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1.
DR   Pfam; PF07281; INSIG; 1.
PE   3: Inferred from homology;
KW   Cholesterol metabolism {ECO:0000256|RuleBase:RU241113};
KW   Endoplasmic reticulum {ECO:0000256|RuleBase:RU241113};
KW   Lipid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Membrane {ECO:0000256|RuleBase:RU241113};
KW   Reference proteome {ECO:0000313|Proteomes:UP000245340};
KW   Steroid metabolism {ECO:0000256|RuleBase:RU241113};
KW   Sterol metabolism {ECO:0000256|RuleBase:RU241113};
KW   Transmembrane {ECO:0000256|RuleBase:RU241113};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU241113}.
FT   TRANSMEM        86..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        180..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        208..227
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU241113"
FT   REGION          42..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   310 AA;  33149 MW;  DE5723F10A406847 CRC64;
     MPRLDDHCWS CSCAQGARHR GLPGAGAGGL AAKVGDMLSP ATLAARRGPD PDSAPARGPR
     SPGAGGRGAG GGPPGSWHHH LVQRSLVLFS VGVVLALVLN LLQVQRNVTL FPEEVIATIF
     SSAWWVPPCC GTAAAVVGLL YPCIDSHLGE PHKFKREWAS VMRCVAVFVG INHASAKLDF
     ANNVQLSLTL AALSLGLWWT FDRSRSGLGL GITIAFLATL ITQLLVYNGV YQYTSPDFLY
     IRSWLPCIFF SGGVTVGNIG RQLAMELVPE NSWRPPYSAS PTSDAGRSRA SFADWWRSPD
     VLQDRCLGGS
//