ID A0A2U3ZIU5_ODORO Unreviewed; 310 AA. AC A0A2U3ZIU5; DT 18-JUL-2018, integrated into UniProtKB/TrEMBL. DT 18-JUL-2018, sequence version 1. DT 02-DEC-2020, entry version 11. DE RecName: Full=Insulin-induced gene protein {ECO:0000256|RuleBase:RU241113}; GN Name=INSIG1 {ECO:0000313|RefSeq:XP_012418902.1}; OS Odobenus rosmarus divergens (Pacific walrus). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Odobenidae; Odobenus. OX NCBI_TaxID=9708 {ECO:0000313|Proteomes:UP000245340, ECO:0000313|RefSeq:XP_012418902.1}; RN [1] {ECO:0000313|RefSeq:XP_012418902.1} RP IDENTIFICATION. RG RefSeq; RL Submitted (MAY-2018) to UniProtKB. CC -!- FUNCTION: Mediates feedback control of cholesterol synthesis. CC {ECO:0000256|RuleBase:RU241113}. CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU241113}; Multi- CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477, CC ECO:0000256|RuleBase:RU241113}. Membrane CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein CC {ECO:0000256|ARBA:ARBA00004141}. CC -!- SIMILARITY: Belongs to the INSIG family. CC {ECO:0000256|ARBA:ARBA00007475, ECO:0000256|RuleBase:RU241113}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR RefSeq; XP_012418902.1; XM_012563448.1. DR GeneID; 101373824; -. DR KEGG; oro:101373824; -. DR CTD; 3638; -. DR Proteomes; UP000245340; Genome assembly. DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell. DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW. DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW. DR GO; GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW. DR InterPro; IPR009904; INSIG-1. DR InterPro; IPR025929; INSIG_fam. DR PANTHER; PTHR15301; PTHR15301; 1. DR PANTHER; PTHR15301:SF11; PTHR15301:SF11; 1. DR Pfam; PF07281; INSIG; 1. PE 3: Inferred from homology; KW Cholesterol metabolism {ECO:0000256|ARBA:ARBA00022548, KW ECO:0000256|RuleBase:RU241113}; KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, KW ECO:0000256|RuleBase:RU241113}; KW Lipid metabolism {ECO:0000256|RuleBase:RU241113}; KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121}; KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU241113}; KW Reference proteome {ECO:0000313|Proteomes:UP000245340}; KW Steroid metabolism {ECO:0000256|ARBA:ARBA00023221, KW ECO:0000256|RuleBase:RU241113}; KW Sterol metabolism {ECO:0000256|ARBA:ARBA00023166}; KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, KW ECO:0000256|RuleBase:RU241113}; KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, KW ECO:0000256|RuleBase:RU241113}. FT TRANSMEM 86..104 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 124..144 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 180..201 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 208..227 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT TRANSMEM 239..259 FT /note="Helical" FT /evidence="ECO:0000256|RuleBase:RU241113" FT REGION 42..75 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 310 AA; 33149 MW; DE5723F10A406847 CRC64; MPRLDDHCWS CSCAQGARHR GLPGAGAGGL AAKVGDMLSP ATLAARRGPD PDSAPARGPR SPGAGGRGAG GGPPGSWHHH LVQRSLVLFS VGVVLALVLN LLQVQRNVTL FPEEVIATIF SSAWWVPPCC GTAAAVVGLL YPCIDSHLGE PHKFKREWAS VMRCVAVFVG INHASAKLDF ANNVQLSLTL AALSLGLWWT FDRSRSGLGL GITIAFLATL ITQLLVYNGV YQYTSPDFLY IRSWLPCIFF SGGVTVGNIG RQLAMELVPE NSWRPPYSAS PTSDAGRSRA SFADWWRSPD VLQDRCLGGS //