ID A0A2T9WS03_9CREN Unreviewed; 322 AA. AC A0A2T9WS03; DT 18-JUL-2018, integrated into UniProtKB/TrEMBL. DT 18-JUL-2018, sequence version 1. DT 13-SEP-2023, entry version 26. DE RecName: Full=DNA repair and recombination protein RadA {ECO:0000256|ARBA:ARBA00018144, ECO:0000256|HAMAP-Rule:MF_00348}; GN Name=radA {ECO:0000256|HAMAP-Rule:MF_00348}; GN ORFNames=DDW09_01920 {ECO:0000313|EMBL:PVU70634.1}; OS Sulfolobus sp. SCGC AB-777_L09. OC Archaea; Thermoproteota; Thermoprotei; Sulfolobales; Sulfolobaceae; OC Sulfolobus. OX NCBI_TaxID=1987492 {ECO:0000313|EMBL:PVU70634.1, ECO:0000313|Proteomes:UP000245548}; RN [1] {ECO:0000313|EMBL:PVU70634.1, ECO:0000313|Proteomes:UP000245548} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=SCGC AB-777_L09 {ECO:0000313|EMBL:PVU70634.1}; RX PubMed=26341207; DOI=10.1128/AEM.01539-15; RA Munson-McGee J.H., Field E.K., Bateson M., Rooney C., Stepanauskas R., RA Young M.J.; RT "Nanoarchaeota, Their Sulfolobales Host, and Nanoarchaeota Virus RT Distribution across Yellowstone National Park Hot Springs."; RL Appl. Environ. Microbiol. 81:7860-7868(2015). CC -!- FUNCTION: Involved in DNA repair and in homologous recombination. Binds CC and assemble on single-stranded DNA to form a nucleoprotein filament. CC Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand CC exchange between homologous DNA molecules. CC {ECO:0000256|ARBA:ARBA00025684, ECO:0000256|HAMAP-Rule:MF_00348, CC ECO:0000256|PIRNR:PIRNR005856}. CC -!- SIMILARITY: Belongs to the eukaryotic RecA-like protein family. CC {ECO:0000256|ARBA:ARBA00008050, ECO:0000256|HAMAP-Rule:MF_00348, CC ECO:0000256|PIRNR:PIRNR005856}. CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ CC whole genome shotgun (WGS) entry which is preliminary data. CC {ECO:0000313|EMBL:PVU70634.1}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; QEFI01000009; PVU70634.1; -; Genomic_DNA. DR AlphaFoldDB; A0A2T9WS03; -. DR Proteomes; UP000245548; Unassembled WGS sequence. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule. DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro. DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-UniRule. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule. DR CDD; cd19515; archRadA; 1. DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1. DR HAMAP; MF_00348; RadA_arch; 1. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR013632; DNA_recomb/repair_Rad51_C. DR InterPro; IPR011938; DNA_recomb/repair_RadA. DR InterPro; IPR016467; DNA_recomb/repair_RecA-like. DR InterPro; IPR010995; DNA_repair_Rad51/TF_NusA_a-hlx. DR InterPro; IPR027417; P-loop_NTPase. DR InterPro; IPR020588; RecA_ATP-bd. DR InterPro; IPR020587; RecA_monomer-monomer_interface. DR NCBIfam; TIGR02236; recomb_radA; 1. DR PANTHER; PTHR22942:SF30; MEIOTIC RECOMBINATION PROTEIN DMC1/LIM15 HOMOLOG; 1. DR PANTHER; PTHR22942; RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER; 1. DR Pfam; PF14520; HHH_5; 1. DR Pfam; PF08423; Rad51; 1. DR PIRSF; PIRSF005856; Rad51; 1. DR SMART; SM00382; AAA; 1. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1. DR SUPFAM; SSF47794; Rad51 N-terminal domain-like; 1. DR PROSITE; PS50162; RECA_2; 1. DR PROSITE; PS50163; RECA_3; 1. PE 3: Inferred from homology; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP- KW Rule:MF_00348}; KW DNA damage {ECO:0000256|HAMAP-Rule:MF_00348, KW ECO:0000256|PIRNR:PIRNR005856}; KW DNA recombination {ECO:0000256|HAMAP-Rule:MF_00348, KW ECO:0000256|PIRNR:PIRNR005856}; KW DNA-binding {ECO:0000256|HAMAP-Rule:MF_00348, KW ECO:0000256|PIRNR:PIRNR005856}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP- KW Rule:MF_00348}; Reference proteome {ECO:0000313|Proteomes:UP000245548}. FT DOMAIN 83..255 FT /note="RecA family profile 1" FT /evidence="ECO:0000259|PROSITE:PS50162" FT DOMAIN 260..322 FT /note="RecA family profile 2" FT /evidence="ECO:0000259|PROSITE:PS50163" FT BINDING 112..119 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000256|HAMAP-Rule:MF_00348" SQ SEQUENCE 322 AA; 35442 MW; 456E4BBA5A621D7E CRC64; MSDGNNKKVK SLSDLPGIGQ AILNKLVDAG YSTLESVAVA SPQDLSVAAG IPLTTAQRII KEAREALDIR FKTALEVKKE RLNTKKITTG SQALDGLLGG GIETRTMTEF FGEFGSGKTQ LCHQLSVNVQ LPFEKGGLNG KAVYIDTEGT FRWERIEAMA KALGLDVDNA MSNIYYMRAI NSDHQMAIVD DLQELISKDP AIKLVIVDSV TSHFRAEYPG RENLAVRQQK MNKHLHQLVR LAEMYDLAVI ITNQVMARPD MFYGDPTVAV GGHTLYHVPG IRVQLKKSRG NKRIARIVDA PHLPEGEVVF AITEEGVRDA EE //